不可逆的共有結合修飾
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- 1. 肝疾患を有する患者における化学療法による肝毒性および用量調整chemotherapy hepatotoxicity and dose modification in patients with liver disease [show details]
… continued chemotherapy treatment without dose modification is appropriate.… secondary biliary sclerosis is irreversible (although treatable with stenting or dilatation) .…
- 2. 腎不全患者に生じる抗がん剤の腎毒性と用量調整：既存の細胞障害性抗癌剤chemotherapy nephrotoxicity and dose modification in patients with renal insufficiency conventional cytotoxic agents [show details]
… and recommended dose modifications in patients with renal insufficiency will be reviewed here.… chronic interstitial nephritis that is generally irreversible can be induced by prolonged therapy with the nitrosoureas carmustine (BiCNU),…
- 3. 限局性HCCへの手術以外の治療：ラジオ波焼灼術、レーザー・マイクロ波アブレーション、経皮的エタノール注入療法、凍結融解壊死治療、高密度焦点式超音波治療法、不可逆電気穿孔法nonsurgical therapies for localized hepatocellular carcinoma radiofrequency ablation laser and microwave thermal ablation percutaneous injection therapies cryoablation high intensity focused ultrasound and irreversible electroporation [show details]
…ablation [RFA]; microwave ablation [MWA]; percutaneous ethanol injection [PEI]; cryoablation; irreversible electroporation [IRE]; transarterial embolization, which includes bland embolization, chemoembolization …
- 4. がん生存者：心血管や呼吸器の問題cancer survivorship cardiovascular and respiratory issues [show details]
… Both aggressive cardiac risk factor modification and appropriate screening are the guiding principles of optimal care,… Cisplatin exerts cytotoxic effects via the formation of covalent adducts with DNA purine bases and inter and intra-strand cross-links,… While there is historical evidence that cardiotoxicity related to anthracyclines is irreversible ,…
- 5. 喘息の遺伝学genetics of asthma [show details]
… a reversible covalent modification of DNA in which a methyl group is transferred from… and alpha-1 antitrypsin deficiency in patients with adult onset asthma and irreversible airflow limitation.…
English Journal
- AJICAP: Affinity Peptide Mediated Regiodivergent Functionalization of Native Antibodies.
- Yamada K, Shikida N, Shimbo K, Ito Y, Khedri Z, Matsuda Y, Mendelsohn BA.
- Angewandte Chemie (International ed. in English). 2019 Apr;58(17)5592-5597.
- The need for atom-precise biomolecule modification, and particularly the irreversible formation of covalent bonds to specific amino acids in proteins, has become an essential issue in the fields of pharmaceuticals and chemical biology. For example, antibody-drug conjugates (ADCs) are increasingly co
- PMID 30854738
- Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.
- Bum-Erdene K, Zhou D, Gonzalez-Gutierrez G, Ghozayel MK, Si Y, Xu D, Shannon HE, Bailey BJ, Corson TW, Pollok KE, Wells CD, Meroueh SO.
- Cell chemical biology. 2019 Mar;26(3)378-389.e13.
- The Hippo pathway coordinates extracellular signals onto the control of tissue homeostasis and organ size. Hippo signaling primarily regulates the ability of Yap1 to bind and co-activate TEA domain (TEAD) transcription factors. Yap1 tightly binds to TEAD4 via a large flat interface, making the devel
- PMID 30581134
- Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.
- Mondal S, Thompson PR.
- Accounts of chemical research. 2019 Mar;52(3)818-832.
- Proteins are well-known to undergo a variety of post-translational modifications (PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group of hydrolases called protein arginine deiminases (PADs). Hundreds of proteins are known to be citrullinated and hypercitrulli
- PMID 30844238
Japanese Journal
- 共有結合が誘発する新規PPARγ活性化機構：植物由来パーシャルアゴニストと不可逆的アンタゴニストによる協調的受容体活性化
- 宮前 友策,大寺 杏奈,吉田 光多郎,秋田 徹,前嶋 一宏,垣塚 彰,増田 誠司,神戸 大朋,永尾 雅哉
- 天然有機化合物討論会講演要旨集 56(0), Poster43, 2014
- <p>1. 序論</p><p> タンパク質に共有結合する低分子化合物の多くは、その活性を不可逆的に阻害する阻害剤である。リガンドによる共有結合が、受容体タンパク質の活性化に働く例は少ない。</p><p> 核内受容体PPARγ (peroxisome proliferator-activated receptor γ)は低分子リガンドにより …
- NAID 130007399544
- 活性硫黄種によるレドックス恒常性維持機構に基づいた新規心不全治療戦略の構築
- 西田 基宏,外山 喬士,熊谷 嘉人 [他],沼賀(冨田) 拓郎
- 薬学雑誌. 乙号 134(12), 1239-1243, 2014
- … covalent modification (<i>S</i>-guanylation) and activation of H-Ras. … We also found that hydrogen sulfide-related reactive sulfur species (RSS) function as potent nucleophiles to eliminate electrophilic modification of H-Ras and suppress the onset of chronic heart failure after myocardial infarction. …
- NAID 130004712987
- Type II isopentenyl diphosphate isomerase : irreversible inactivation by covalent modification of flavin
Related Links
- Enzyme Regulation (Part 5 of 5) - Covalent Modification - Irreversible Moof University Loading... Unsubscribe from Moof University? Cancel Unsubscribe Working...
- Modification is not readily reversible in some cases. Some proteins in signal-transduction pathways, such as Ras and Src (a protein tyrosine kinase), are localized to the cytoplasmic face of the plasma membrane by the irreversible ...
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★リンクテーブル★
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- 英
- irreversible covalent modification
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不可逆的共有結合修飾
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- 関
- alter、alteration、amend、amendment、change、metamorphic、metamorphosis、metamorphotic、modify、revise、revision
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- 関
- covalency、covalent attachment、covalent binding、covalent bond、covalently
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- 関
- irreversibility、irreversibly