ヨードペルオキシダーゼ
- 関
- deiodinase
WordNet
- a salt or ester of hydriodic acid
- any of a group of enzymes (occurring especially in plant cells) that catalyze the oxidation of a compound by a peroxide
PrepTutorEJDIC
- ヨウ化物
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/20 19:13:39」(JST)
[Wiki en表示]
| iodide peroxidase |
| Identifiers |
| EC number |
1.11.1.8 |
| CAS number |
9031-28-1 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
| thyroid peroxidase |
| Identifiers |
| Symbol |
TPO |
| Entrez |
7173 |
| HUGO |
12015 |
| OMIM |
606765 |
| RefSeq |
NM_175722 |
| UniProt |
P07202 |
| Other data |
| EC number |
1.11.1.8 |
| Locus |
Chr. 2 pter-p24 |
Thyroid peroxidase or thyroperoxidase (TPO) is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones.[1] In humans, thyroperoxidase is encoded by the TPO gene.[2]
Contents
- 1 Catalyzed reaction
- 2 Function
- 3 Stimulation and inhibition
- 4 Clinical significance
- 5 Diagnostic use
- 6 References
- 7 External links
Catalyzed reaction
+ I− + H+ + H2O2 ⇒ + 2 H2O
Iodide is oxidized to iodine radical which immediately reacts with tyrosine.
+ I− + H+ + H2O2 ⇒ + 2 H2O
The second iodine atom is added in similar manner to the reaction intermediate 3-iodotyrosine.
Function
Thyroid hormone synthesis, with thyroid peroxidase performing the
oxidation step seen at center-left in the image.
[3]
Inorganic iodine enters the body primarily as iodide, I−. After entering the thyroid follicle (or thyroid follicular cell) via a Na+/I− symporter (NIS) on the basolateral side, iodide is shuttled across the apical membrane into the colloid via pendrin, after which thyroid peroxidase oxidizes iodide to atomic iodine (I) or iodinium (I+). The "organification of iodine," the incorporation of iodine into thyroglobulin for the production of thyroid hormone, is nonspecific; that is, there is no TPO-bound intermediate, but iodination occurs via reactive iodine species released from TPO.[4] The chemical reactions catalyzed by thyroid peroxidase occur on the outer apical membrane surface and are mediated by hydrogen peroxide.
Stimulation and inhibition
TPO is stimulated by TSH, which upregulates gene expression.
TPO is inhibited by the thioamide drugs, such as propylthiouracil and methimazole.[5] In laboratory rats with insufficient iodine intake, genistein has demonstrated inhibition of TPO.[6]
Clinical significance
Thyroid peroxidase is a frequent epitope of autoantibodies in autoimmune thyroid disease, with such antibodies being called anti-thyroid peroxidase antibodies (anti-TPO antibodies). This is most commonly associated with Hashimoto's thyroiditis. Thus, an antibody titer can be used to assess disease activity in patients that have developed such antibodies.[7][8]
Diagnostic use
In diagnostic immunohistochemistry, the expression of thyroid peroxidase (TPO) is lost in papillary thyroid carcinoma.[9]
References
- ^ Ruf J, Carayon P (January 2006). "Structural and functional aspects of thyroid peroxidase". Arch. Biochem. Biophys. 445 (2): 269–77. doi:10.1016/j.abb.2005.06.023. PMID 16098474.
- ^ Kimura S, Kotani T, McBride OW, Umeki K, Hirai K, Nakayama T, Ohtaki S (August 1987). "Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs". Proc. Natl. Acad. Sci. U.S.A. 84 (16): 5555–9. doi:10.1073/pnas.84.16.5555. PMC 298901. PMID 3475693.
- ^ Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 1300. ISBN 1-4160-2328-3.
- ^ Kessler J, Obinger C, Eales G (July 2008). "Factors influencing the study of peroxidase-generated iodine species and implications for thyroglobulin synthesis". Thyroid 18 (7): 769–74. doi:10.1089/thy.2007.0310. PMID 18631006.
- ^ Nagasaka A, Hidaka H (July 1976). "Effect of antithyroid agents 6-propyl-2-thiouracil and 1-methyl-2-mercaptoimidazole on human thyroid iodine peroxidase". J. Clin. Endocrinol. Metab. 43 (1): 152–8. doi:10.1210/jcem-43-1-152. PMID 947933.
- ^ Doerge DR, Sheehan DM (June 2002). "Goitrogenic and estrogenic activity of soy isoflavones". Environ. Health Perspect. 110 Suppl 3: 349–53. doi:10.1289/ehp.02110s3349. PMC 1241182. PMID 12060828.
- ^ McLachlan SM, Rapoport B (2000). "Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator". Int. Rev. Immunol. 19 (6): 587–618. doi:10.3109/08830180009088514. PMID 11129117.
- ^ Chardès T, Chapal N, Bresson D, Bès C, Giudicelli V, Lefranc MP, Péraldi-Roux S (June 2002). "The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases". Immunogenetics 54 (3): 141–57. doi:10.1007/s00251-002-0453-9. PMID 12073143.
- ^ Tanaka T, Umeki K, Yamamoto I, Sugiyama S, Noguchi S, Ohtaki S (1996). "Immunohistochemical loss of thyroid peroxidase in papillary thyroid carcinoma: strong suppression of peroxidase gene expression". J. Pathol. 179 (1): 89–94. doi:10.1002/(SICI)1096-9896(199605)179:1<89::AID-PATH546>3.0.CO;2-R. PMID 8691351.
External links
- Thyroid Peroxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
| CatalaseCytochrome c peroxidaseEosinophil peroxidaseGlutathione peroxidase
Horseradish peroxidaseLactoperoxidaseMyeloperoxidaseThyroid peroxidaseDeiodinase
- Iodothyronine deiodinase
- Iodotyrosine deiodinase
|
Oxidoreductases: peroxidases (EC 1.11)
|
|
| 1.11.1.1-14 |
|
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| 1.11.1.15 (peroxiredoxin) |
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Thyroid hormone metabolism enzymes and transporters
|
|
| Enzymes |
- Thyroid peroxidase
- Iodotyrosine deiodinase
- Dual oxidase 1/Dual oxidase 2
- Iodothyronine deiodinase
- Diiodotyrosine transaminase
|
|
| Transporters |
- Monocarboxylate transporter 8|Monocarboxylate transporter 8 (MCT8)
- Sodium-iodide symporter
- Pendrin
|
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Index of hormones
|
|
| Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
|
|
| Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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|
UpToDate Contents
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English Journal
- Effect of Cinnamic Acid for Controlling Gray Mold on Table Grape and Its Possible Mechanisms of Action.
- Zhang Z1, Qin G, Li B, Tian S.
- Current microbiology.Curr Microbiol.2015 Sep;71(3):396-402. doi: 10.1007/s00284-015-0863-1. Epub 2015 Jul 5.
- Cinnamic acid (CA) is an organic acid and is widely used in food industry as a common food additive. Previous studies showed that CA has the antimicrobial activity in vitro, but little is known about the effect of CA on controlling the fruit decay in vivo. In present study, we showed that applicatio
- PMID 26143055
- Soy isoflavones protect against H2O2-induced injury in human umbilical vein endothelial cells.
- Jin L1, Zhao X1, Qin Y1, Zhu W1, Zhang W1, Liu A2, Luo Z1.
- Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):4476-82. doi: 10.3892/mmr.2015.3949. Epub 2015 Jun 17.
- The aim of this study was to investigate the effects of soy isoflavones on the injury of human umbilical vein endothelial cells induced by H2O2. EVC‑304 cells were preincubated with soy isoflavones for 12 h, and then exposed to 100 µM H2O2 for 1 h. Cell viability was evaluated by a 3‑(4,5‑
- PMID 26095641
- Coniferyl alcohol hinders the growth of tobacco BY-2 cells and Nicotiana benthamiana seedlings.
- Väisänen EE1, Smeds AI, Fagerstedt KV, Teeri TH, Willför SM, Kärkönen A.
- Planta.Planta.2015 Sep;242(3):747-60. doi: 10.1007/s00425-015-2348-7. Epub 2015 Jun 25.
- MAIN CONCLUSION: Externally added coniferyl alcohol at high concentrations reduces the growth of Nicotiana cells and seedlings. Coniferyl alcohol is metabolized by BY-2 cells to several compounds. Coniferyl alcohol (CA) is a common monolignol and a building block of lignin. The toxicity of monoligno
- PMID 26108783
Japanese Journal
- Two Novel Mutations in the Thyroid Peroxidase Gene with Goitrous Hypothyroidism
- TAJIMA TOSHIHIRO,TSUBAKI JUNKO,FUJIEDA KENJI
- Endocrine journal 52(5), 643-645, 2005-10-20
- NAID 10016782539
- Dual method for the determination of peroxidase activity and total peroxides-iodide leads to a significant increase of peroxidase activity in human sera
- Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings
Related Links
- thyroid peroxidase thyroid oxidoreductase that catalyzes incorporation of iodide to tyrosine residues in the production of thyroxine, in a process termed organification (q.v.); deficiency of this enzyme leads to a loss of the iodotyrosine ...
- Résultats pour "Iodide peroxidase" sur Internet, dans les universités et dans les œuvres littéraires cyclopaedia.net ... Endocrine and Reproductive Physiology, a volume in the Mosby Physiology Monograph Series, explains the ...
★リンクテーブル★
[★]
- 英
- iodide peroxidase
- 関
- 脱ヨウ素酵素
[★]
- 関
- I、I2、iodine、iodo
[★]
ペルオキシダーゼ、過酸化酵素
- 関
- myeloperoxidase