WordNet
- a fibrous band of scar tissue that binds together normally separate anatomical structures
- abnormal union of bodily tissues; most common in the abdomen
- (physics and chemistry) the simplest structural unit of an element or compound
- located between cells
PrepTutorEJDIC
- 粘着,付着
- 分子《略》『mol』) / (一般に)(…の)微量《+『of』+『名』》
- 細胞間の,細胞間にある
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/10 11:23:31」(JST)
[Wiki en表示]
Intercellular adhesion molecule (ICAM), N-terminal domain |
structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1
|
Identifiers |
Symbol |
ICAM_N |
Pfam |
PF03921 |
Pfam clan |
CL0011 |
InterPro |
IPR013768 |
SCOP |
1zxq |
SUPERFAMILY |
1zxq |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe; PDBj |
PDBsum |
structure summary |
|
In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces.
Mammalian intercellular adhesion molecules include:
- ICAM-1
- ICAM2
- ICAM3
- ICAM4
- ICAM5
References
- ^ Gahmberg CG, Tolvanen M, Kotovuori P (April 1997). "Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands". Eur. J. Biochem. 245 (2): 215–32. doi:10.1111/j.1432-1033.1997.00215.x. PMID 9151947.
This article incorporates text from the public domain Pfam and InterPro IPR013768
Membrane proteins: cell adhesion molecules
|
|
Calcium-independent |
IgSF CAM |
- N-CAM (Myelin protein zero)
- ICAM (1, 5)
- VCAM-1
- PE-CAM
- L1-CAM
- Nectin (PVRL1, PVRL2, PVRL3)
|
|
|
Calcium-dependent |
Cadherins |
Classical |
|
|
Desmosomal |
- Desmoglein (DSG1, DSG2, DSG3, DSG4)
- Desmocollin (DSC1, DSC2, DSC3)
|
|
Protocadherin |
|
|
Unconventional/ungrouped |
- T-cadherin
- CDH4
- CDH5
- CDH6
- CDH8
- CDH11
- CDH12
- CDH15
- CDH16
- CDH17
- CDH9
- CDH10
|
|
|
Selectins |
- E-selectin
- L-selectin
- P-selectin
|
|
Integrins |
- LFA-1 (CD11a+CD18)
- Integrin alphaXbeta2 (CD11c+CD18)
- Macrophage-1 antigen (CD11b+CD18)
- VLA-4 (CD49d+CD29)
- Glycoprotein IIb/IIIa (ITGA2B+ITGB3)
|
|
|
Other |
- Lymphocyte homing receptor: CD44
- L-selectin
- integrin (VLA-4, LFA-1)
- Carcinoembryonic antigen
- CD22
- CD24
- CD44
- CD146
- CD164
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Dynamically Regulated CFTR Expression and Its Functional Role in Cutaneous Wound Healing.
- Dong J1,2,3, Jiang X2,4, Zhang X2, Liu KS2, Zhang J2, Chen J2,5, Yu MK2, Tsang LL2, Chung YW2, Wang Y3, Zhou WL1, Chan HC2,4,5.
- Journal of cellular physiology.J Cell Physiol.2015 Sep;230(9):2049-58. doi: 10.1002/jcp.24931.
- The physiological role of cystic fibrosis transmembrane conductance regulator (CFTR) in keratinocytes and skin wound healing is completely unknown. The present study shows that CFTR is expressed in the multiple layers of keratinocytes in mouse epidermis and exhibits a dynamic expression pattern in a
- PMID 25641604
- Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates.
- Fornari E1, Roberts CJ2, Temperton RH3, O'Shea JN3.
- Journal of colloid and interface science.J Colloid Interface Sci.2015 Sep 1;453:252-9. doi: 10.1016/j.jcis.2015.05.007. Epub 2015 May 14.
- We demonstrate in this work the deposition of a large biological molecule (fibronectin) on polymeric substrates in a high vacuum environment using an electrospray deposition system. Fibronectin was deposited and its distribution and structure investigated and retention of function (ability to promot
- PMID 25989056
Japanese Journal
- Ga-Al-As (830 nm)ダイオードレーザー照射によるラット関節リウマチのIntercellular Adhesion Molecule-1遺伝子発現の抑制
- Correlation Between Circulating Angiogenic Cell Mobilizations and Recovery of Coronary Flow Reserve in Patients With Acute Myocardial Infarction
- JEONG Han Saem,HONG Soon Jun,PARK Jae Hyoung,KIM Jong-Ho,CHOI Seung Cheol,AHN Chul-Min,KIM Je Sang,LIM Do-Sun
- Circulation journal : official journal of the Japanese Circulation Society 76(5), 1213-1221, 2012-04-25
- … The negative correlation was found between changes in high-sensitive C-reactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. …
- NAID 10030132744
Related Links
- intercellular adhesion molecule, ICAM Any of a group of immunoglobulin-like proteins on the surface of cells that help them bind to each other or to the extracellular matrix that surrounds them. These proteins also participate in cell-to ...
- 147840 - INTERCELLULAR ADHESION MOLECULE 1; ICAM1 - CD54;; SURFACE ANTIGEN OF ACTIVATED B CELLS, BB2; BB2;; ANTIGEN IDENTIFIED BY MONOCLONAL ANTIBODY BB2 ... ...
Related Pictures
★リンクテーブル★
[★]
- 同
- intercellular adhesion molecule
種類
- 関
- adhesion molecules, intercellular
[★]
- 関
- CAM、ICAM、intercellular adhesion molecule、leukocyte adhesion molecule
[★]
- 英
- intercellular adhesion molecule、ICAM
- 関
- 細胞接着分子、細胞間接着因子
[★]
- 関
- cell adhesion molecule、intercellular adhesion molecule
[★]
- 英
- intercellular adhesion molecule
- 関
- 細胞接着分子、細胞間接着分子
[★]
- 日
- 関
- 同
- ICAM- 1
- 同
- ICAM-1
- 同
- ICAM- 1
- 同
- ICAM-1
[★]
[★]
- 関
- mol、molecular、numerator
[★]
- 関
- cell-to-cell