WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
a fibrous band of scar tissue that binds together normally separate anatomical structures
abnormal union of bodily tissues; most common in the abdomen
(physics and chemistry) the simplest structural unit of an element or compound

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
粘着,付着
分子《略》『mol』) / (一般に)(…の)微量《+『of』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/09 20:22:19」(JST)

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Cell Adhesion Molecules (CAMs) are proteins located on the cell surface^[1] involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. Essentially, cell adhesion molecules help cells stick to each other and to their surroundings.

These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding).

Families of CAMs

Most of the CAMs belong to four protein families: Ig (immunoglobulin) superfamily (IgSF CAMs), the integrins, the cadherins, and the selectins.

One classification system involves the distinction between calcium-independent CAMs and calcium-dependent CAMs.^[2]

Calcium-independent

IgSF CAMs

Main article: IgSF CAM

Immunoglobulin superfamily CAMs (IgSF CAMs) are either homophilic or heterophilic and bind integrins or different IgSF CAMs.

Lymphocyte homing receptors

These are also known as addressins. Two well known examples are CD34 and GLYCAM-1.

Calcium-dependent

Integrins

The Integrins are a family of heterophilic CAMs that bind IgSF CAMs or the extracellular matrix. They are heterodimers, called alpha and beta. Eighteen different alpha subunits that combine with 8 different beta subunits to form twenty-four known integrins; however not all combinations are observed.

Cadherins

The cadherins are a family of homophilic CAMs, Ca²⁺-dependent. The most important members of this family are E-cadherins (epithelial), P-cadherins (placental), and N-cadherins (neural).

Selectins

The selectins are a family of heterophilic CAMs that bind fucosylated carbohydrates, e.g., mucins. The three family members are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein ligand-1 (PSGL-1), which is a mucin-type glycoprotein expressed on all white blood cells.

References

^ MeSH Cell+Adhesion+Molecules
^ Brackenbury R, Rutishauser U, Edelman GM (January 1981). "Distinct calcium-independent and calcium-dependent adhesion systems of chicken embryo cells". Proc. Natl. Acad. Sci. U.S.A. 78 (1): 387–91. doi:10.1073/pnas.78.1.387. PMC 319058. PMID 6165990. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=319058.

UpToDate Contents

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English Journal

Demasking of epithelial cell adhesion molecule (EpCAM) on circulating epithelial tumor cells by Tween®20 treatment in breast cancer patients.

Hekimian K, Stein EL, Pachmann U, Pachmann K.SourceClinic for Internal Medicine II, Oncology Research Laboratory, Friedrich Schiller University Jena, Jena, Germany. katya.hekimian@med.uni-jena.de
Clinical chemistry and laboratory medicine : CCLM / FESCC.Clin Chem Lab Med.2012 Dec 7;50(4):701-8. doi: 10.1515/cclm.2011.812.
BACKGROUND: The epithelial cell adhesion molecule (EpCAM) embedded in the plasma membrane of circulating epithelial tumor cells (CETC) is used for detection and enrichment of circulating tumor cells in peripheral blood and as a target for anti-epithelial antibodies elicited during immune response in
PMID 22505561

Regulation of integrin adhesions by varying the density of substrate-bound epidermal growth factor.

Shahal T, Geiger B, Dunlop IE, Spatz JP.SourceDepartment of Molecular Cell Biology, Weizmann Institute of Science, 76100, Rehovot, Israel.
Biointerphases.Biointerphases.2012 Dec;7(1-4):23. Epub 2012 Mar 3.
Substrates coated with specific bioactive ligands are important for tissue engineering, enabling the local presentation of extracellular stimulants at controlled positions and densities. In this study, we examined the cross-talk between integrin and epidermal growth factor (EGF) receptors following
PMID 22589066

Japanese Journal

<原著>上皮悪性腫瘍の肉腫様変化は骨芽細胞分化の側面を有する--骨分化マーカーを用いた検討と解析

村上哲平,井上敬夫,西村俊司,伊藤彰彦,赤木將男
近畿大学医学雑誌 40(1-2), 39-46, 2015-06
… 近年, 上皮性の細胞接着分子であるcell adhesion molecule 1（CADM1）が骨肉腫細胞株および肉腫摘出標本, 正常骨芽細胞などの骨性間葉系細胞に強発現していることが明らかとなり, CADM1が骨分化マーカーの側面を持っている可能性が示された. …
NAID 120005626251

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation

Yamana Shota,Tokiyama Amina,Mizutani Kiyohito,Hirata Ken-ichi,Takai Yoshimi,Rikitake Yoshiyuki
PLoS ONE 10(4), e0124259, 2015-04-20
NAID 120005611305

Direct Infection of Primary Salivary Gland Epithelial Cells by Human T Lymphotropic Virus Type I in Patients With Sjögren's Syndrome

Nakamura Hideki,Takahashi Yoshiko,Yamamoto-Fukuda Tomomi,Horai Yoshiro,Nakashima Yoshikazu,Arima Kazuhiko,Nakamura Tatsufumi,Koji Takehiko,Kawakami Atsushi
Arthritis & Rheumatology 67(4), 1096-1106, 2015-04
… Methods SGECs were cultured with the HTLV-I-producing CD4+ T cell line HCT-5 or with Jurkat cells. … After coculture of SGECs with HCT-5, the expression of cytokines and chemokines, including soluble intercellular adhesion molecule 1, RANTES, and interferon γ-induced protein 10 kd (IP-10/CXCL10) was increased in a time-dependent manner. …
NAID 120005603845

Related Pictures

★リンクテーブル★

リンク元	「細胞接着分子」「leukocyte adhesion molecule」
拡張検索	「platelet endothelial cell adhesion molecule-1」「cell adhesion molecule L1」「neural cell adhesion molecule L1」「neuron-glia cell adhesion molecule」
関連記事	「adhesion」「molecule」「cell」