慢性肝炎
WordNet
- being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
- of long duration; "chronic money problems" (同)continuing
- habitual; "a chronic smoker" (同)inveterate
- inflammation of the liver caused by a virus or a toxin
PrepTutorEJDIC
- (病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった
- 肝[臓]炎
UpToDate Contents
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English Journal
- Keratosis lichenoides chronica in an Indian child following erythroderma.
- Ghorpade A.Author information Department of Dermatology, Venereology, and Leprosy, J.L.N. Hospital and Research Centre, Bhilai Steel Plant, Bhilai, India. draghorpade@yahoo.comAbstractA 4-year-old boy presented with mildly itchy, linear, skin lesions over the trunk, arms, and face of 3 months' duration. He had previously been admitted to a private hospital for generalized exfoliation of the skin following drug intake for fever and throat pain. The nature of the drugs was not known. The exfoliative dermatitis was treated with oral prednisolone, 10 mg daily, tapered over 3 weeks. No further topical or oral medication was given. The present skin lesions started 1 month after the cessation of the steroids. There was no family history of skin lesions, voice changes, or systemic complaints. Cutaneous examination showed multiple violaceous, linear, reticulate ridges with adherent scaling over the chest, back, and neck. There were scaly, flat-topped papules over the extensor aspects of both upper arms and the buttocks, and scaly plaques over the cheeks (Figs 1a-d and 2a,b). The scalp showed diffuse greasy scaling. There were no oral, genital, axillary, or eye lesions. The nails were normal. Systemic examination did not reveal any abnormal finding. Routine hematologic investigations, liver and kidney function tests, tests for hepatitis B and C, and enzyme-linked immunosorbent assay (ELISA) for HIV were normal. Histopathology from skin lesions on the back revealed hyperkeratosis, patchy parakeratosis, follicular plugging, alternating irregular acanthosis and epidermal thinning, basal cell degeneration, and a band-like inflammatory infiltrate of lymphocytes, histiocytes, and a few plasma cells (Fig. 3). Based on the classical clinical features and histopathology, keratosis lichenoides chronica was diagnosed, and topical 1% hydrocortisone acetate cream, twice daily, was prescribed. There was slight relief of pruritus at a follow-up visit after 3 weeks; however, the patient was subsequently lost to follow-up.
- International journal of dermatology.Int J Dermatol.2008 Sep;47(9):939-41. doi: 10.1111/j.1365-4632.2008.03618.x. Epub 2008 Mar 3.
- A 4-year-old boy presented with mildly itchy, linear, skin lesions over the trunk, arms, and face of 3 months' duration. He had previously been admitted to a private hospital for generalized exfoliation of the skin following drug intake for fever and throat pain. The nature of the drugs was not know
- PMID 18318700
- Pityriasis lichenoides chronica: an association with autoimmune hepatitis?
- Saltik-Temizel IN, Ersoy-Evans S, Demir H, Yüce A.Author information Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey. isaltik@hacettepe.edu.trAbstractPityriasis lichenoides is an uncommon, benign skin disorder with two major variants: acute and chronic. Autoimmune hepatitis comprises heterogeneous forms of chronic hepatitis that are generally progressive and often fluctuating. Two major forms of this entity are recognized. Herein, we report the concurrence of pityriasis lichenoides chronica with type I autoimmune hepatitis in a child, which, to the best of our knowledge, has not been previously reported. Although it is hard to say whether an etiologic relationship or coincidental coexistence occurred between the two entities in our patient, some common mechanisms may be involved in both diseases.
- Pediatric dermatology.Pediatr Dermatol.2007 Jan-Feb;24(1):71-3.
- Pityriasis lichenoides is an uncommon, benign skin disorder with two major variants: acute and chronic. Autoimmune hepatitis comprises heterogeneous forms of chronic hepatitis that are generally progressive and often fluctuating. Two major forms of this entity are recognized. Herein, we report the c
- PMID 17300656
- Assessment of correlation between histopathologic changes of gastric mucosa according to Whitehead's classification and extent of liver damage according to Knodell's scale in patients with chronic hepatopathy.
- Orłowski M, Stalke P, Michalska Z, Sikorska K, Witczak-Malinowska K, Eilert-Zygadłowska J, Stolarczyk J.Author information Clinic of Infectious Diseases, Medical University of Gdańsk, Gdańsk, Poland.AbstractAIM OF THE STUDY: Patients with chronic liver damage often suffer from functional disturbances and pathologic changes in the stomach, including ulceration, erosions and chronic gastritis. It was attempted to establish whether there is a correlation between histopathologic abnormalities of the gastric mucosa and the extent of histopathologic changes in liver bioptates, i.e. inflammatory activity and fibrosis (Knodell's index) in patients with chronic hepatopathy.
- Medical science monitor : international medical journal of experimental and clinical research.Med Sci Monit.2003 Aug;9 Suppl 3:60-3.
- AIM OF THE STUDY: Patients with chronic liver damage often suffer from functional disturbances and pathologic changes in the stomach, including ulceration, erosions and chronic gastritis. It was attempted to establish whether there is a correlation between histopathologic abnormalities of the gastri
- PMID 15156615
Japanese Journal
- 肝臓機能障害患者に対するL- オルニチン・L-アスパルテート剤の影響についての臨床的研究
- 南九州国立療養所共同研究班,小清 水邦夫
- 医療 20(4), 339-346, 1966
- … Total 51 patients were classified into, 10 cases of hepatitis acuta, 24 cases of hepatitis chronica, 12 cases of serum hepatitis and 4 cases of liver cirrhosis.These patients were treated by preparations containing 20-40ml of L-Ornithine-L-Aspaltate daily for 2-4 weeks by means of I. …
- NAID 130004310732
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★リンクテーブル★
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- 英
- chronic hepatitis
- ラ
- hepatitis chronica
- 同
- 慢性ウイルス性肝炎 chronic viral hepatitis
- 関
- 肝炎、肝炎ウイルス。新犬山分類
まとめ
- 6か月以上肝炎が持続している病態で、主にウイルス性とくにC型肝炎ウイルスによるものが大半を占める。多くは無症状であり検査値異常で気づかれる。検査上、ALT優位にトランスアミナーゼが上昇、ガンマグロブリン上昇、ICH停滞率上昇、血小板は肝臓の線維化を反映して低下している。蛋白合成能の指標となるアルブミンやコリンエステラーゼは正常である。病理所見としては肝小葉を中心とした持続性炎症である。肝門脈域の限界板破壊像(piecemeal necrosis)がみられ、慢性肝炎の進行度の指標となる。肝門部の壊死が拡大してお互い重なり合う壊死像(bridging necrosis)は、肝硬変の進展リスクを反映する。腹腔鏡では、肝臓表面に肝臓の再生を示す斑紋と門脈域辺縁の肝細胞が壊死後の血液貯留を反映する赤色紋理を認める。診断はウイルスの検出と肝生検による組織診団によってなされ、治療は原因疾患に応じた治療を行う。
概念
疫学
- B型が約20%、C型が約75%、非B非C型慢性肝炎や自己免疫性肝炎(AIH)はそれぞれ数%。(IMD)
病因
ウイルス性
- B型肝炎ウイルス：キャリアの10-20%が慢性肝炎に移行。B型肝硬変から肝細胞癌は2.5-3%/年
- C型肝炎ウイルス：罹患者の60-70%が慢性肝炎に移行。C型肝硬変から肝細胞癌は5-7%/年
病理
- 肝臓表面の赤色紋理：腹腔鏡上の所見。点状、小斑状、網状の赤色調局面。piece meal necrosisなどにより門脈域辺縁の肝細胞が壊死した後血液の貯留を示す。肝炎の活動性の所見。
症状
- 多くは無症状
- B型慢性肝炎：急性増悪期に黄疸や食欲低下、全身倦怠感を認めることがある
- C型慢性肝炎：黄疸は極めて稀
検査
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- 関
- chronically、chronicity
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