hemorrhagic disease of the newborn

新生児出血性疾患

WordNet

1. a special situation; "this thing has got to end"; "it is a remarkable thing"
2. a separate and self-contained entity
3. an action; "how could you do such a thing?"
4. an artifact; "how does this thing work?"
5. an entity that is not named specifically; "I couldnt tell what the thing was"
6. any attribute or quality considered as having its own existence; "the thing I like about her is ..."
7. a persistent illogical feeling of desire or aversion; "he has a thing about seafood"; "she has a thing about him"
8. a special abstraction; "a thing of the spirit"; "things of the heart"
9. a special objective; "the thing is to stay in bounds"
10. a statement regarded as an object; "to say the same thing in other terms"; "how can you say such a thing?"
11. an event; "a funny thing happened on the way to the..."
12. an impairment of health or a condition of abnormal functioning
13. recently born; "a newborn infant"
14. having just or recently arisen or come into existence; "new nations"; "with newborn fears" (同)new-sprung

PrepTutorEJDIC

1. 〈C〉(形のある)『物』,物体;(生物に対しての)『無生物』 / 〈C〉(形のない)『もの』,事,事柄,でき事 / 《複数形で》事情,事態,状勢,状況 / 《複数形で》(すべての)事物,事柄 / 《通例 the~》(努力・活動などの)目的,目標 / 〈C〉衣服,衣類・《one's things》持ち物,所持品,身の回り品 / 《複数形で》道具,用具・〈C〉《親愛・哀れみ・軽べつなどの感情をこめて》人,者,やつ / 《the~》《話》(…の)流行《+in+名》
2. 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
3. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
4. 女性の話術芸人 =diseur
5. 《前述の名詞または文脈でそれと分かる名詞に付けて》『その』,あの,名の / 《唯一の事物に付けて》 / 《方角・自然現象に付けて》 / 《用具・楽器・特定の病気などに付けて》 / 《修飾吾[句]を伴う名詞に付けて》 / 《単数普通名詞に付けて》(1)《種族全体》…『というもの』 / 《複数名詞または集合名詞に付けて》 / 《単位》『…につき;…単位[で]』 / 《身体の一部に付けて,所有格に代わる》 / 《形容詞に付けて》 / 《固有名詞に付けて》 / 《強意用法に》『随一の』,典型的な / 《「the+比較級,the+比較級」の形で》『…すればするほどそれだけ』 / 《比較級の前に》(…につれて,のために)『それだけ』,ますます
6. 生まれたばかりの / 生まれ変わった,再生の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/25 20:33:29」(JST)

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[Wiki en表示]

Not to be confused with Hemolytic disease of the newborn.

Haemorrhagic disease of the newborn
Classification and external resources
Vitamin K1
ICD-10	P53
ICD-9	776.0
DiseasesDB	29544
MedlinePlus	007320
eMedicine	ped/966
MeSH	D006475

Haemorrhagic disease of the newborn is a coagulation disturbance in newborns due to vitamin K deficiency. As a consequence of vitamin K deficiency there is an impaired production of coagulation factors II, VII, IX, X, C and S by the liver.

Causes

Newborns are relatively vitamin K deficient for a variety of reasons. They have low vitamin K stores at birth, vitamin K passes the placenta poorly, the levels of vitamin K in breast milk are low and the gut flora has not yet been developed (vitamin K is normally produced by bacteria in the intestines).

Presentation

The disease causes an increased risk of bleeding. The most common sites of bleeding are the umbilicus, mucous membranes, gastrointestinal tract, circumcision and venipunctures.

Treatment

Treatment consists of vitamin K supplementation. This is often given prophylactically to newborns shortly after birth.

References

UpToDate Contents

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• 1. ビタミンKの概要 overview of vitamin k
• 2. 健康な新生児のルーチンのマネージメントの概要 overview of the routine management of the healthy newborn infant
• 3. 小児における紫斑の評価 evaluation of purpura in children
• 4. 小児における上部消化管出血に対するアプローチ approach to upper gastrointestinal bleeding in children
• 5. 正期産児のための母乳の栄養組成 nutritional composition of human milk for full term infants

English Journal

• Haemorrhagic stroke in term and late preterm neonates.

• Bruno CJ, Beslow LA, Witmer CM, Vossough A, Jordan LC, Zelonis S, Licht DJ, Ichord RN, Smith SE.Author information Division of Neonatal-Perinatal Medicine, The Children's Hospital at Montefiore, Albert Einstein School of Medicine, , Bronx, New York, USA.AbstractOBJECTIVE: Few data regarding causes and outcomes of haemorrhagic stroke (HS) in term neonates are available. We characterised risk factors, mechanism and short-term outcomes in term and late preterm neonates with acute HS.
• Archives of disease in childhood. Fetal and neonatal edition.Arch Dis Child Fetal Neonatal Ed.2014 Jan;99(1):F48-53. doi: 10.1136/archdischild-2013-304068. Epub 2013 Aug 30.
• OBJECTIVE: Few data regarding causes and outcomes of haemorrhagic stroke (HS) in term neonates are available. We characterised risk factors, mechanism and short-term outcomes in term and late preterm neonates with acute HS.DESIGN: Prospective cohort.SETTING: Single-centre tertiary care stroke regist
• PMID 23995383

• Vitamin K deficiency bleeding: a case study.

• Woods CW, Woods AG, Cederholm CK.Author information Wake Forest Baptist Health (Mr Woods) and Novant Health Forsyth Medical Center (Ms Woods), Winston Salem, and Alamance Regional Medical Center, Burlington, North Carolina (Mrs Cederholm).AbstractVitamin K deficiency bleeding (VKDB), formerly known as hemorrhagic disease of the newborn (HDN), is a bleeding disorder in neonates that is caused by inadequate serum levels of vitamin K. Vitamin K is a nutrient essential for adequate function of the coagulation cascade. Certain internal and external factors place newborn infants at higher risk for VKDB. Therefore, vitamin K prophylaxis has become the standard of care for newborns. Although the American Academy of Pediatrics recommends the administration of vitamin K to newborns, some parents are choosing to withhold vitamin K administration at birth. This case study describes an infant who developed VKDB in the absence of vitamin K prophylaxis. Although parents ultimately have the right to choose whether or not to administer vitamin K, as healthcare professionals, it is important to provide education regarding the potential complications of withholding vitamin K and the signs of VKDB if vitamin K prophylaxis at birth is withheld.
• Advances in neonatal care : official journal of the National Association of Neonatal Nurses.Adv Neonatal Care.2013 Dec;13(6):402-7. doi: 10.1097/ANC.0000000000000026.
• Vitamin K deficiency bleeding (VKDB), formerly known as hemorrhagic disease of the newborn (HDN), is a bleeding disorder in neonates that is caused by inadequate serum levels of vitamin K. Vitamin K is a nutrient essential for adequate function of the coagulation cascade. Certain internal and extern
• PMID 24300958

• Notes from the field: late vitamin K deficiency bleeding in infants whose parents declined vitamin K prophylaxis--Tennessee, 2013.

• Centers for Disease Control and Prevention (CDC).AbstractVitamin K deficiency bleeding (VKDB) is a coagulopathy that develops in infants who do not have sufficient vitamin K stores to support production of clotting factors. In adults, vitamin K is absorbed from food and from vitamin K synthesized by gut bacteria. However, placental transfer in humans is limited; cord blood and infant liver reserve levels of vitamin K are substantially below adult levels. As a result, infants are predisposed to develop VKDB, which is classified as early, classic, and late, according to when it presents. In the United States, administration of intramuscular vitamin K at birth to prevent all forms of VKDB has been standard practice since first recommended by the American Academy of Pediatrics in 1961. Without this prophylaxis, incidence of early and classical VKDB ranges from 0.25% to 1.7% of births; incidence of late VKDB ranges from 4.4 to 7.2 per 100,000 infants. The relative risk for developing late VKDB has been estimated at 81 times greater among infants who do not receive intramuscular vitamin K than in infants who do receive it.
• MMWR. Morbidity and mortality weekly report.MMWR Morb Mortal Wkly Rep.2013 Nov 15;62(45):901-2.
• Vitamin K deficiency bleeding (VKDB) is a coagulopathy that develops in infants who do not have sufficient vitamin K stores to support production of clotting factors. In adults, vitamin K is absorbed from food and from vitamin K synthesized by gut bacteria. However, placental transfer in humans is l
• PMID 24226627

Japanese Journal

• ITP合併妊娠による胎児期脳室内出血後水頭症の1例

• 伊藤 英道,榊原 陽太郎,平本 準,吉田 浩,酒井 晃治,小野寺 英孝,和久井 大輔,田口 芳雄
• 脳神経外科ジャーナル 18(1), 56-61, 2009-01-20
• ITP合併妊娠による胎児脳室内出血後水頭症の1例を報告する.胎生34週に母体超音波にて胎児脳室内出血と頭囲拡大がみられ,35週に帝王切開にて出生.出生時,児の血小板数は1.7×10^4/μlで,血小板輸血,ガンマグロブリン大量療法,ステロイド療法を行った.生後3日目に血小板数は7.6×10^4/μlに増加し,水頭症に対しOmmayaリザーバー留置術を施行したところ,再び脳室内出血をきたした.保存的 …
• NAID 110007029865

• 疾患 血液疾患(ビタミンKを含む) (特集/当直医師に必要な新生児の知識)

• 藤沢 康司
• 小児科診療 69(3), 395-401, 2006-03
• NAID 40007155198

Related Links

• Hemorrhagic disease of the newborn: MedlinePlus Medical ...

A lack of vitamin K causes hemorrhagic disease of the newborn. Vitamin K plays an important role in blood clotting. Babies often have low levels of vitamin K for a variety of reasons. Vitamin K does not move easily across ...

• Hemorrhagic Disease of Newborn: Background ...

In the past, the term hemorrhagic disease of the newborn was used to describe bleeding disorders in neonates associated with a traumatic birth or hemophilia. The proper diagnostic term that has been adopted is ...

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★リンクテーブル★

リンク元	「新生児出血性疾患」
関連記事	「disease」「newborn」「hemorrhagic」「thing」

「新生児出血性疾患」

　　[★]

英

hemorrhagic disease of newborn, hemorrhagic disease of the newborn

関

新生女児性器出血

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「newborn」

　　[★]

• n.

• 新生児

• adj.

• 新生児の

関

neonatal、neonate、newborn animal、newborn infant

　 　 　

「hemorrhagic」

　　[★]

• adj.

• 出血性の、易出血性の

関

haemophilic、haemorrhagic、hemophilic

　

「thing」

　　[★]