WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm

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(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
(砂糖などが)粒の,粒状の / (紙・革などが)表面がざらざらしている

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/03 22:00:08」(JST)

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Histopathologic image of granular cell tumor of the skin

Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time.

It is also known as Abrikossoff's tumor,^[1] Granular cell myoblastoma,^[1] Granular cell nerve sheath tumor,^[1] and Granular cell schwannoma.^[1])

Pathology

Granular cell tumors show similarity to neural tissue, as can be demonstrated by immunohistochemistry and ultrastructural evidence using electron microscopy.

Multiple granular cell tumors may seen in the context of LEOPARD syndrome, due to a mutation in the PTPN11 gene.^[2]

Epidemiology

Granular cell tumors can affect all parts of the body; however, the head and neck areas are affected 45% to 65% of the time. Of the head and neck cases 70% of lesions are located intraorally (tongue, oral mucosa, hard palate). The next most common location that lesions are found in the head and neck area is the larynx (10%).^[3] Granular cell tumors are also found in the internal organs, particularly in the upper aerodigestive tract.

The usual presentation is of slow growing behavior, forming a polygonal accumulation of secondary lysosomes in the cytoplasm. Granular cell tumors are typically solitary and are rarely larger than three centimeters. This type of tumor has been found to be both benign and malignant, although malignancy is rare and comprises only 2% of all granular cell tumors.^[4]

Treatment

The primary method for treatment is surgical, not medical. Radiation and chemotherapy are not needed for benign lesions and are not effective for malignant lesions.

Benign granular cell tumors have a recurrence rate of 2% to 8% when resection margins are deemed clear of tumor infiltration. When the resection margins of a benign granular cell tumor are positive for tumor infiltration the recurrence rate is increased to 20%. Malignant lesions are aggressive and difficult to eradicate with surgery and have a recurrence rate of 32%.

References

^ ^a ^b ^c ^d Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1796, 1804. ISBN 1-4160-2999-0.
^ Schrader, KA.; Nelson, TN.; De Luca, A.; Huntsman, DG.; McGillivray, BC. (Feb 2009). "Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11.". Clin Genet 75 (2): 185–9. doi:10.1111/j.1399-0004.2008.01100.x. PMID 19054014.
^ Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
^ Fanburg-Smith JC, Meis-Kindblom JM, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. Jul 1998;22(7):779-94.

UpToDate Contents

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1. 上部消化管の上皮下病変評価のための超音波内視鏡検査 endoscopic ultrasound for the characterization of subepithelial lesions of the upper gastrointestinal tract
2. 食道の良性病変 benign lesions of the esophagus
3. 口腔病変 oral lesions
4. 平滑筋肉腫 cutaneous leiomyomatosis
5. 消化管間質腫瘍、平滑筋腫、および消化管の平滑筋肉腫の局所治療 local treatment for gastrointestinal stromal tumors leiomyomas and leiomyosarcomas of the gastrointestinal tract

English Journal

Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia.

Johansson P1,2, Bergmann A3, Rahmann S4, Wohlers I4, Scholtysik R2, Przekopowitz M2, Seifert M2, Tschurtschenthaler G5, Webersinke G5, Jäger U6, Siebert R3, Klein-Hitpass L2, Dührsen U1, Dürig J1, Küppers R2.
International journal of cancer. Journal international du cancer.Int J Cancer.2016 Jan 1;138(1):121-4. doi: 10.1002/ijc.29697. Epub 2015 Jul 30.
The pathogenesis of T-cell large granular lymphocytic leukemia (T-LGL) is poorly understood, as STAT3 mutations are the only known frequent genetic lesions. Here, we identified non-synonymous alterations in the TNFAIP3 tumor suppressor gene in 3 of 39 T-LGL. In two cases these were somatic mutations
PMID 26199174

Fine needle aspiration of secondary synovial sarcoma of the thyroid gland.

Murro D1, Slade JM1, Syed S1, Gattuso P1.
Diagnostic cytopathology.Diagn Cytopathol.2015 Nov;43(11):928-32. doi: 10.1002/dc.23327. Epub 2015 Aug 25.
Synovial sarcomas (SS) of the head and neck region are extremely rare and arise in only 5% of cases. We present a case of secondary SS of the thyroid originally diagnosed as medullary carcinoma on fine needle aspiration (FNA). A 41-year-old man presented with several weeks of dysphonia and a left th
PMID 26304470

Granular Cell Tumors on Unusual Anatomic Locations.

Kim HJ1, Lee MG2.
Yonsei medical journal.Yonsei Med J.2015 Nov;56(6):1731-4. doi: 10.3349/ymj.2015.56.6.1731.
Granular cell tumors (GCTs) are soft tissue tumors, which are thought to be derived from Schwann cells. Although most GCTs are reported to arise in tongue and oral cavity (30-50%), they can appear on any anatomic sites, even visceral organs. Herein, we report 5 cases of GCTs on unusual anatomic loca
PMID 26446660

Japanese Journal

気管支顆粒細胞腫の2例

鈴木奈緒子,星利良,古田則行,杉山裕子,佐藤之俊,元井紀子,石川雄一,宝来威
日本臨床細胞学会雑誌 51(5), 354-359, 2012-09-22
NAID 10030873952

Coexistence of Sporadic Cerebellar Hemangioblastoma and Pituitary Null Cell Adenoma : Simultaneous Expression of von Hippel-Lindau Gene Product : Case Report

SHIMODA Yoshiteru,OGAWA Yoshikazu,ENDO Hidenori,WATANABE Mika,TOMINAGA Teiji
Neurologia medico-chirurgica = 神経外科 52(8), 591-594, 2012-08-15
… Magnetic resonance imaging showed a cystic tumor in the left cerebellar hemisphere and another lesion in the sella turcica. … The diagnoses were cerebellar hemangioblastoma and pituitary null cell adenoma. … Additional immunohistochemical investigation using VHL disease gene-related protein in both tumors showed minute granular positive staining in the cytoplasm of stromal cells in the former, and diffuse and strong granular cytoplasmic positive staining in the latter. …
NAID 10030694759

Related Pictures

★リンクテーブル★

リンク元	「顆粒細胞腫」
関連記事	「granular」「tumor」「cell」

「顆粒細胞腫」

Granular cell tumor
	2-cm tumor presented as an abdominal wall mass in a middle-aged woman
Classification and external resources
ICD-10	D36.1 (ILDS D36.170)
ICD-O	M9582/0
DiseasesDB	31674