顆粒細胞性筋芽細胞腫
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- (砂糖などが)粒の,粒状の / (紙・革などが)表面がざらざらしている
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/19 14:40:54」(JST)
[Wiki en表示]
| Granular cell tumor |
|
| 2-cm tumor presented as an abdominal wall mass in a middle-aged woman |
| Classification and external resources |
| Specialty |
oncology |
| ICD-10 |
D36.1 (ILDS D36.170) |
| ICD-O |
M9582/0 |
| DiseasesDB |
31674 |
|
[edit on Wikidata]
|
Histopathologic image of granular cell tumor of the skin
Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time.
It is also known as Abrikossoff's tumor,[1] Granular cell myoblastoma,[1] Granular cell nerve sheath tumor,[1] and Granular cell schwannoma.[1])
Contents
- 1 Pathology
- 2 Epidemiology
- 3 Treatment
- 4 See also
- 5 References
Pathology
Granular cell tumors show similarity to neural tissue, as can be demonstrated by immunohistochemistry and ultrastructural evidence using electron microscopy.
Multiple granular cell tumors may seen in the context of LEOPARD syndrome, due to a mutation in the PTPN11 gene.[2]
These tumors on occasion may appear similar to neoplasms of renal (relating to the kidneys) origin or other soft tissue neoplasms.
Epidemiology
Granular cell tumors can affect all parts of the body; however, the head and neck areas are affected 45% to 65% of the time. Of the head and neck cases 70% of lesions are located intraorally (tongue, oral mucosa, hard palate). The next most common location that lesions are found in the head and neck area is the larynx (10%).[3] Granular cell tumors are also found in the internal organs, particularly in the upper aerodigestive tract.
The usual presentation is of slow growing behavior, forming a polygonal accumulation of secondary lysosomes in the cytoplasm. Granular cell tumors are typically solitary and are rarely larger than three centimeters. This type of tumor has been found to be both benign and malignant, although malignancy is rare and comprises only 2% of all granular cell tumors.[4]
Treatment
The primary method for treatment is surgical, not medical. Radiation and chemotherapy are not needed for benign lesions and are not effective for malignant lesions.
Benign granular cell tumors have a recurrence rate of 2% to 8% when resection margins are deemed clear of tumor infiltration. When the resection margins of a benign granular cell tumor are positive for tumor infiltration the recurrence rate is increased to 20%. Malignant lesions are aggressive and difficult to eradicate with surgery and have a recurrence rate of 32%.
See also
- List of cutaneous conditions
- Glassy cell carcinoma
References
- ^ a b c d Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1796, 1804. ISBN 1-4160-2999-0.
- ^ Schrader, KA.; Nelson, TN.; De Luca, A.; Huntsman, DG.; McGillivray, BC. (Feb 2009). "Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11.". Clin Genet. 75 (2): 185–9. doi:10.1111/j.1399-0004.2008.01100.x. PMID 19054014.
- ^ Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
- ^ Fanburg-Smith JC, Meis-Kindblom JM, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. Jul 1998;22(7):779-94.
UpToDate Contents
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English Journal
- Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells.
- Jung JY, Oh JH, Lee DH, Lee S, Chung JH.SourceDepartment of Dermatology, Seoul National University College of Medicine, Medical Research Center, Seoul National University, Medical Research Center, Seoul National University, Seoul, Korea; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Medical Research Center, Seoul National University, Seoul, Korea; Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
- Journal of cellular physiology.J Cell Physiol.2013 Nov;228(11):2243-51. doi: 10.1002/jcp.24393.
- ABO blood group is determined by carbohydrate antigens, called ABH antigens. It has been known that the change of carbohydrate antigen expression, including ABH antigens, has correlation with the tumor metastasis and survival; however, the exact mechanism remains to be elucidated. ABH antigens are e
- PMID 23625752
- Update on Hypophysitis and TTF-1 Expressing Sellar Region Masses.
- Kleinschmidt-Demasters BK, Lopes MB.SourceDepartment of Pathology, The University of Colorado School of Medicine, Aurora, CO; Department of Neurosurgery, The University of Colorado School of Medicine, Aurora, CO; Department of Neurology, The University of Colorado School of Medicine, Aurora, CO.
- Brain pathology (Zurich, Switzerland).Brain Pathol.2013 Sep;23(5):495-514. doi: 10.1111/bpa.12068. Epub 2013 Jul 5.
- This article reviews recent literature on sellar region masses that most closely mimic nonsecretory pituitary adenomas: hypophysitis, pituicytoma, spindle cell oncocytoma, and granular cell tumor of neurohypophysis. Even today, these four entities often cannot be confidently distinguished from each
- PMID 23701182
- Granular cell tumor of the cervical esophagus: case report and literature review of an unusual cause of Dysphagia.
- Huang AT, Dominguez LM, Powers CN, Reiter ER.SourceDepartment of Otolaryngology - Head and Neck Surgery, Virginia Commonwealth University, Box 980146, Richmond, VA, 23298, USA, athuang@mdanderson.org.
- Head and neck pathology.Head Neck Pathol.2013 Sep;7(3):274-9. doi: 10.1007/s12105-012-0408-x. Epub 2012 Nov 11.
- Granular cell tumors (GCT) of the head and neck are not uncommon; however, involvement of the cervical esophagus is rare. Characterized by an infiltrative growth pattern, these benign tumors are historically difficult to surgically excise and are radioresistant. We present here a case of dysphagia c
- PMID 23143390
Japanese Journal
- 日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 41(7), 1330-1335, 1999-07-20
- NAID 10007043007
- YAG laser in endobronchial granular cell myoblastoma.
- Granular cell myoblastoma involving multiple organs.
★リンクテーブル★
[★]
- 英
- granular cell tumor
- 同
- 顆粒細胞性筋芽細胞腫 granular cell myoblastoma、筋芽細胞腫 myoblastoma
[★]
- 英
- granular cell myoblastoma
- 関
- 顆粒細胞腫
[★]
- 英
- granular cell myoblastoma
- 関
- 顆粒細胞腫
[★]
- 関
- granule、particulate
[★]
- 関
- muscle tissue neoplasm
[★]
細胞