glucose-dependent insulin-releasing peptide

胃抑制ペプチド

WordNet

1. relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
2. addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
3. contingent on something else (同)dependant, qualified
4. (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
5. hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells
6. a monosaccharide sugar that has several forms; an important source of physiological energy
7. amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein

PrepTutorEJDIC

1. 『頼っている』,依存している,従属している / 扶養される人(家族)
2. インシュリン(膵臓(すいぞう)ホルモンで糖尿病治療剤)
3. ブドウ糖

UpToDate Contents

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• 1. インスリン分泌および膵β細胞の機能 insulin secretion and pancreatic beta cell function
• 2. 成人の1型糖尿病におけるインスリン療法 insulin therapy in adults with type 1 diabetes mellitus
• 3. インスリン作用 insulin action
• 4. 糖尿病でない成人における低血糖症：診断的アプローチ hypoglycemia in adults without diabetes mellitus diagnostic approach
• 5. 小児および思春期における1型糖尿病のマネージメント management of type 1 diabetes mellitus in children and adolescents

English Journal

• Immunohistochemical Analysis of IA-2 Family of Protein Tyrosine Phosphatases in Rat Gastrointestinal Endocrine Cells.

• Gomi H, Kubota-Murata C, Yasui T, Tsukise A, Torii S.SourceDepartment of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, Kanagawa, Japan (HG, TY, AT).
• The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.J Histochem Cytochem.2013 Feb;61(2):156-68. doi: 10.1369/0022155412466872. Epub 2012 Oct 18.
• Islet-associated protein-2 (IA-2) and IA-2β (also known as phogrin) are unique neuroendocrine-specific protein tyrosine phosphatases (PTPs). The IA-2 family of PTPs was originally identified from insulinoma cells and discovered to be major autoantigens in type 1 diabetes. Despite its expression in
• PMID 23087044

• Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.

• Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N.SourceDepartment of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Kyoto 606-8507, Japan.
• The Journal of biological chemistry.J Biol Chem.2013 Jan 18;288(3):1929-38. doi: 10.1074/jbc.M112.423137. Epub 2012 Nov 28.
• Gastric inhibitory polypeptide (GIP) is an incretin released from enteroendocrine K-cells in response to nutrient ingestion. GIP potentiates glucose-stimulated insulin secretion and induces energy accumulation into adipose tissue, resulting in obesity. Plasma GIP levels are reported to be increased
• PMID 23192339

• Glucose metabolism is altered after loss of L cells and α-cells but not influenced by loss of K cells.

• Pedersen J, Ugleholdt RK, Jørgensen SM, Windeløv JA, Grunddal KV, Schwartz TW, Füchtbauer EM, Poulsen SS, Holst PJ, Holst JJ.SourceDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. jensp@sund.ku.dk
• American journal of physiology. Endocrinology and metabolism.Am J Physiol Endocrinol Metab.2013 Jan 1;304(1):E60-73. doi: 10.1152/ajpendo.00547.2011. Epub 2012 Oct 31.
• The enteroendocrine K and L cells are responsible for secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon like-peptide 1 (GLP-1), whereas pancreatic α-cells are responsible for secretion of glucagon. In rodents and humans, dysregulation of the secretion of GIP, GLP-1, and g
• PMID 23115082

Related Links

• Glucagon-like peptide-1 and glucose-dependent insulin ...

1. Digestion. 1995;56(2):117-26. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Herrmann C(1), Göke R, Richter G, Fehmann HC, Arnold R, Göke B. ...

• Glucose-Dependent Insulin-Releasing Peptide in Noninsulin ...

ABSTRACT. Glucose-dependent insulin-releasing peptide or gastric inhibitory polypeptide (GIP) is released into the circulation after ingestion of a mixed meal and is thought to enhance glucose-induced insulin release. We ...

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★リンクテーブル★

リンク元	「胃抑制ペプチド」
関連記事	「dependent」

「胃抑制ペプチド」

　　[★]

英

gastric inhibitory peptide gastric inhibitory polypeptide GIP

同

糖依存性インスリン放出ペプチド glucose-dependent insulin-releasing peptide

関

消化管ホルモン、ホルモン

分類

• 消化管ホルモン

性状

• ポリペプチド 43aa

産生組織

• 十二指腸、空腸の粘膜(K細胞)

作用

• 消化管内の糖・脂肪酸の存在によりインスリンの放出を刺激

GIP is sometimes called "glucose-dependent insulinotropic" peptide because it stimulates pancreatic insulin secretion in the presence of hyperglucemia.

• 胃酸抑制作用？(エンテロガストロン enterogastrone)　←　否定的

外分泌

• ↓：胃：胃酸分泌　←　上に書いてあることと違う・・・
• ↓：腸：腸液分泌抑制(QB CBT vol2 p.295)

内分泌

• ↑：膵：インスリン放出

分泌の調整

↑

• 脂肪酸、アミノ酸、経口グルコース投与

「dependent」

　　[★]

• adj.

• 依存性の、依存的な、依存型の、依存の

関

depend、dependence、dependency、dependently