WordNet

(communication theory) a numerical measure of the uncertainty of an outcome; "the signal contained thousands of bits of information" (同)selective information, entropy
a message received and understood (同)info
formal accusation of a crime
knowledge acquired through study or experience or instruction
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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《単数形で冠詞をつけずに》(…についての)『情報』,『知識』《『about』(『on, as to』)+『名』(『wh-節・句』)》 / 〈U〉案内;〈C〉案内所,案内係
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1. びまん性大細胞型B細胞性リンパ腫および原発性縦隔大細胞型B細胞リンパ腫の病理学 pathobiology of diffuse large b cell lymphoma and primary mediastinal large b cell lymphoma
2. 肥満の病因 pathogenesis of obesity
3. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
4. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia
5. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia

English Journal

Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases.

Rubattu S, Sciarretta S1, Volpe M.Author information 1†IRCCS Neuromed, Pozzilli (Isernia), Italy.AbstractANP (atrial natriuretic peptide), discovered 30 years ago in rat cardiac atria, has been extensively investigated with regard to physiology, pathophysiology, cardiovascular disease therapeutics and molecular genetic aspects. Besides its diuretic, natriuretic and vasorelaxant effects, novel properties of this hormone have been described. Thus anti-hypertrophic, anti-fibrotic, anti-proliferative and anti-inflammatory actions suggest that ANP contributes not only to haemodynamic homoeostasis and adjustments, but has also a role in cardiovascular remodelling. Circulating ANP levels represent a valuable biomarker in cardiovascular diseases. ANP structure is highly conserved among species, indicating a key role in cardiovascular health. Thus an abnormal ANP structure may contribute to an increased risk of disease due to altered functions at either the vascular or cardiac level. Among others, the 2238T>C exon 3 variant has been associated with endothelial cell damage and dysfunction and with an increased risk of acute cardiovascular events, a frameshift mutation within exon 3 has been related to increased risk of atrial fibrillation, and ANP gene variants have been linked to increased risk of hypertension in different ethnic groups. On the other hand, the rs5068 variant, falling within the 3' UTR and associated with higher circulating ANP levels, has been shown to have a beneficial cardioprotective and metabolic effect. Dissecting out the disease mechanisms dependent on specific ANP molecular variants may reveal information useful in the clinical setting for diagnostic, prognostic and therapeutic purposes. Furthermore, insights from molecular genetic analysis of ANP may well integrate advancing knowledge on the role of ANP as a significant biomarker in patients affected by cardiovascular diseases.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jul 1;127(1):1-13. doi: 10.1042/CS20130427.
ANP (atrial natriuretic peptide), discovered 30 years ago in rat cardiac atria, has been extensively investigated with regard to physiology, pathophysiology, cardiovascular disease therapeutics and molecular genetic aspects. Besides its diuretic, natriuretic and vasorelaxant effects, novel properti
PMID 24611929

Probing phosphatase activity using redox active nanoparticles: A novel colorimetric approach for the detection of enzyme activity.

Hayat A1, Gonca Bulbul2, Andreescu S3.Author information 1Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13676, USA; Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS Institute of Information Technology (CIIT), Lahore, Pakistan.2Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13676, USA.3Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13676, USA. Electronic address: eandrees@clarkson.edu.AbstractA new colorimetric assay for the detection of alkaline phosphatase (ALP) activity is reported based on the surface reactivity and optical properties of redox active nanoparticles of cerium oxide, or nanoceria. The method takes advantage of nanoceria color changes after interaction with products of the ALP catalyzed reaction, resulting in charge transfer complexes with very strong absorption characteristics. The developed assay is easy-to-use, robust and cost effective and does not involve labeled reagents, secondary enzymes or soluble dyes. Hydrolytic products of more stable substrates (catechol monophosphate, ascorbic 2-phosphate and hydroquinone diphosphate) that could previously not be used in ALP assays can be conveniently colorimetrically detected with this assay. A detection limit of 0.04U/L ALP with a linear range up to 2U/L was obtained with ascorbic 2-phosphate substrate. The proposed assay can eliminate multistep procedures and minimize problems associated with the poor stability of substrates and enzyme labels of conventional ALP assays. The assay has been adapted to a paper platform and has demonstrated functionality for ALP detection in human serum. This sensing concept can find wide applications as a general approach for improving sensitivity and simplifying detection schemes of colorimetric bioassays, e.g. enzyme, gene, immuno and aptamer assays and related affinity sensing methods.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Jun 15;56:334-9. doi: 10.1016/j.bios.2014.01.003. Epub 2014 Jan 20.
A new colorimetric assay for the detection of alkaline phosphatase (ALP) activity is reported based on the surface reactivity and optical properties of redox active nanoparticles of cerium oxide, or nanoceria. The method takes advantage of nanoceria color changes after interaction with products of t
PMID 24531308

Comparative analysis of surface wax in mature fruits between Satsuma mandarin (Citrus unshiu) and 'Newhall' navel orange (Citrus sinensis) from the perspective of crystal morphology, chemical composition and key gene expression.

Wang J1, Hao H1, Liu R1, Ma Q1, Xu J1, Chen F2, Cheng Y3, Deng X1.Author information 1Key Laboratory of Horticultural Plant Biology(Ministry of Education), National Key Laboratory of Crop Genetic Improvement, College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.2Department of Food, Nutrition and Packaging Sciences, Clemson University, Clemson, SC 29634, United States.3Key Laboratory of Horticultural Plant Biology(Ministry of Education), National Key Laboratory of Crop Genetic Improvement, College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan 430070, People's Republic of China. Electronic address: yjcheng@mail.hzau.edu.cn.AbstractSurface wax of mature Satsuma mandarin (Citrus unshiu) and 'Newhall' navel orange (Citrus sinensis) was analysed by crystal morphology, chemical composition, and gene expression levels. The epicuticular and total waxes of both citrus cultivars were mostly composed of aldehydes, alkanes, fatty acids and primary alcohols. The epicuticular wax accounted for 80% of the total wax in the Newhall fruits and was higher than that in the Satsuma fruits. Scanning electron microscopy showed that larger and more wax platelets were deposited on the surface of Newhall fruits than on the Satsuma fruits. Moreover, the expression levels of genes involved in the wax formation were consistent with the biochemical and crystal morphological analyses. These diversities of fruit wax between the two cultivars may contribute to the differences of fruit postharvest storage properties, which can provide important information for the production of synthetic wax for citrus fruits.
Food chemistry.Food Chem.2014 Jun 15;153:177-85. doi: 10.1016/j.foodchem.2013.12.021. Epub 2013 Dec 11.
Surface wax of mature Satsuma mandarin (Citrus unshiu) and 'Newhall' navel orange (Citrus sinensis) was analysed by crystal morphology, chemical composition, and gene expression levels. The epicuticular and total waxes of both citrus cultivars were mostly composed of aldehydes, alkanes, fatty acids
PMID 24491718

Japanese Journal

Network Completion for Static Gene Expression Data

Natsu Nakajima,Tatsuya Akutsu
情報処理学会研究報告. BIO, バイオ情報学 2015-BIO-41(7), 1-4, 2015-03-13
… In this report, we address the problem of completing and inferring gene regulatory networks under stationary conditions from static data, where network completion is to make the minimum amount of modifications to an initial network so that the completed network is most consistent with the expression data in which additions and deletions of edges are basic modification operations. …
NAID 110009884012