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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/25 00:56:01」(JST)

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A gastrinoma is a tumor in the pancreas or duodenum that secretes excess of gastrin leading to ulceration in the duodenum, stomach and the small intestine. There is hypersecretion of the HCl acid into the duodenum, which causes the ulcers. Excessive HCl acid production also causes hyperperistalsis, and inhibits the activity of lipase, causing severe diarrhea.

It is frequently the source of the gastrin in Zollinger-Ellison syndrome.^[1]

It is most commonly found in the duodenum (50-70%) and less commonly in the pancreas (20-40%).^[2] Those occurring in the pancreas have a greater potential for malignancy. Most gastrinomas are found in the gastrinoma triangle; this is bound by the junction of cystic and common bile ducts, junction of the second and third parts of the duodenum, and the junction of the neck and body of the pancreas.

Clinical Picture

Gastrinoma causes the following symptoms:

Hypergastrinemia
Ulcers of the duodenum, stomach, and small intestine.
Severe diarrhea.
Generalised cancer symptoms.

Diagnostics

1 Fasting Serum Gastrin. 2 In case of moderate hypergastrinemia, a secretin stimulation test can help in the diagnosis. 3 localization by somatostatin scintigraphy

Treatment

Treatment can involve surgery or proton pump inhibitors.

References

^ "Dorlands Medical Dictionary:gastrinoma".
^ http://emedicine.medscape.com/article/184332-overview

External links

-462749670 at GPnotebook
USC
Emedicine
The Johns Hopkins University Pancreatic Islet Cell Tumor / Pancreatic Endocrine Neoplasms webpage

Gastrinoma Triangle

This article about a neoplasm is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. ゾリンジャー - エリソン症候群（ガストリノーマ）の臨床症状および診断 clinical manifestations and diagnosis of zollinger ellison syndrome gastrinoma
2. ゾリンジャー - エリソン症候群（ガストリノーマ）のマネージメントおよび予後 management and prognosis of the zollinger ellison syndrome gastrinoma
3. 酸関連疾患治療のためのプロトンポンプ阻害剤の概要および比較 overview and comparison of the proton pump inhibitors for the treatment of acid related disorders
4. 多発性内分泌腫瘍1型：臨床症状および診断 multiple endocrine neoplasia type 1 clinical manifestations and diagnosis
5. ガストリンの生理学 physiology of gastrin

English Journal

Diagnostic performance of somatostatin receptor PET/CT using (68)Ga-DOTANOC in gastrinoma patients with negative or equivocal CT findings.

Naswa N, Sharma P, Soundararajan R, Karunanithi S, Nazar AH, Kumar R, Malhotra A, Bal C.SourceDepartment of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Abdominal imaging.Abdom Imaging.2012 Jun 29. [Epub ahead of print]
PURPOSE: Contrast-enhanced CT (CECT) is a standard investigative procedure in the localization of gastrinomas. Small tumors are often missed and metastatic lesions may remain occult on CT. The purpose of present study was to prospectively evaluate the diagnostic performance of (68)Ga-labeled [1,4,7,
PMID 22743840

Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis.

Grin A, Kim YI, Mustard R, Streutker CJ, Riddell RH.SourceDepartments of Laboratory Medicine and Pathobiology, St Michael's Hospital, Toronto, ON, Canada. grina@smh.ca
The American journal of surgical pathology.Am J Surg Pathol.2012 Jun;36(6):935-40.
Helicobacter pylori (HP) has been associated with neuroendocrine tumors of the stomach and duodenum. Gastric enterochromaffin-like (ECL) cell tumors and duodenal gastrinomas have also been associated with HP gastritis in separate series but have not been reported together. With other possible causes
PMID 22588069

Japanese Journal

十二指腸カルチノイドの病態と治療

丸山保彦,渡辺文利,花井洋行
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 53(8), 1979-1990, 2011-08-20
… 神経内分泌腫瘍（Neuroendocrine tumors : NETs）における分類でNET G1と定義された．十二指腸カルチノイドの多くは組織免疫染色でホルモン産生を認めるがホルモンによる症状を引き起こさないNon-functioning NETsで，gastrinoma（Zollinger-Ellison syndrome : ZES）等の症状を呈するものは一部である．緩徐に発育する一方，比較的初期からリンパ節転移を伴う症例もあり「癌もどき」とは言い切れない側面を持つ．明確な治療方針は確立し …
NAID 10029562596

膵内分泌腫瘍の病態生理と臨床像ガストリノーマ (内分泌腺腫瘍--基礎・臨床研究のアップデート) -- (膵内分泌腫瘍)

土井隆一郎
日本臨床 69(-) (995), 585-592, 2011-03
NAID 40018749441

Related Pictures

★リンクテーブル★

リンク元	「ガストリン産生腫瘍」「膵内分泌腫瘍」「gastrin-producing tumor」

「ガストリン産生腫瘍」

Gastrinoma
	Classification and external resources
	Micrograph of a neuroendocrine tumour of the stomach. H&E stain.
ICD-O:	M8153/1
DiseasesDB	14279
eMedicine	med/2678
MeSH	D015408

　　[★]

英: gastrinoma
同: G細胞腫, ガストリノーマ
関: ゾリンジャー・エリソン症候群 ZES、多発性内分泌腫瘍症; 消化管神経内分泌腫瘍.xls

[show details]

ガストリン産生腫瘍 : 約 25,800 件
ガストリノーマ : 約 18,200 件

検査

カルシウム検査
セクレチン負荷試験

局在診断

CT、MRI、選択的動脈撮影、選択的動脈内セクレチン注入試験、ソマトスタチン受容体シンチグラム

治療

内科的治療：ヒスタミンH2受容体拮抗薬
外科的治療：切除可能であれば、膵腫瘍切除術

「膵内分泌腫瘍」

　　[★]

英: pancreatic endocrine tumor, endocrine tumor of pancreas
同: 膵内分泌性膿瘍、膵内分泌系腫瘍

インスリノーマ(insulinoma)：インスリン分泌腫瘍：インスリン：膵内分泌腫瘍の中で最も多い
グルカゴノーマ(glucagonoma)：グルカゴン分泌腫瘍：グルカゴン：膵内分泌腫瘍の15%
ガストリノーマ(gastrinoma)：ガストリン分泌腫瘍：ガストリン：

「gastrin-producing tumor」

　　[★] ガストリン産生腫瘍

関: gastrinoma

[urlDorlands_Medical_Dictionary:gastrinoma-1] "Dorlands Medical Dictionary:gastrinoma".

[2] ttp://emedicine.medscape.com/article/184332-overview

匿名

検索

案内

案内

gastrinoma