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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/27 02:33:30」(JST)

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Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City.^[1] Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.^[2]

Fluocinolone acetonide intravitreal implants have been used to treat non-infectious uveitis. A systematic review could not determine whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis.^[3]

Flucinolone is a group V (0.025%) or group VI (0.01%) corticosteroid under US classification.

References

^ J S Mills, A. Bowers, Carl Djerassi and H.J. Ringold, Steroids CXXXVII. Synthesis of a New Class of Potent Cortical Hormones. 6α,9α-Difluoro-16α-Hydroxyprednisolone and its Acetonide, Journal of the American Chemical Society, 80, 3399-3404 (1960)
^ Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Matsumoto T, Young MF, Olsen BR, Kuboki T. Fluocinolone Acetonide is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration. J Bone Miner Res. 2015. http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2502/abstract
^ Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J (2016). "Corticosteroid implants for chronic non-infectious uveitis". Cochrane Database Syst Rev. 2: CD010469. doi:10.1002/14651858.CD010469.pub2. PMID 26866343.

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1. 黒色表皮腫 acanthosis nigricans
2. 肝斑 melasma
3. ブドウ膜炎：治療 uveitis treatment
4. 思春期および成人における脂漏性皮膚炎 seborrheic dermatitis in adolescents and adults
5. 自己免疫性甲状腺疾患における前脛骨部粘液水腫（甲状腺皮膚症） pretibial myxedema thyroid dermopathy in autoimmune thyroid disease

English Journal

Efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin cream in chinese patients with melasma: a randomized, double-blind, placebo-controlled, multicenter, parallel-group study.

Gong Z1, Lai W, Zhao G, Wang X, Zheng M, Li L, Yang Q, Dang Y, Liu L, Zou Y.
Clinical drug investigation.Clin Drug Investig.2015 Jun;35(6):385-95. doi: 10.1007/s40261-015-0292-8.
BACKGROUND AND OBJECTIVES: This study aimed to determine the efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin (FAHT) cream for the treatment of moderate and severe facial melasma. The primary objective was assessment of clinical efficacy, instrumental measured efficacy, and
PMID 25989732

Sustained-release fluocinolone acetonide intravitreal insert for macular edema: clinical pharmacology and safety evaluation.

Sadiq MA1, Agarwal A, Soliman MK, Hanout M, Sarwar S, Do DV, Nguyen QD.
Expert opinion on drug safety.Expert Opin Drug Saf.2015 May 20:1-10. [Epub ahead of print]
INTRODUCTION: Inflammation plays a key role in the pathological processes leading to macular edema. Sustained release, low-dose intraocular corticosteroid delivery devices provide long-term anti-inflammatory therapy. Recently, a novel fluocinolone acetonide intravitreal insert (FAi, Iluvien), has be
PMID 25994877

Spontaneous dislocation of fluocinolone acetonide implant pellets from their suture struts.

Itty S1, Callanan D2, Jones R2, Pecen P1, Martel J1, Jaffe GJ3.
American journal of ophthalmology.Am J Ophthalmol.2015 May;159(5):868-76.e1. doi: 10.1016/j.ajo.2015.01.031. Epub 2015 Jan 30.
PURPOSE: To characterize spontaneous dislocation of the fluocinolone acetonide sustained release implant (Retisert; Bausch & Lomb) drug pellet from its strut.DESIGN: Retrospective, observational case series.METHODS: The medical records of 224 patients in whom 407 fluocinolone acetonide implants
PMID 25640410

Japanese Journal

Degradation of Corticosteroids during Activated Sludge Processing

Chemical and Pharmaceutical Bulletin 62(1), 72-76, 2014
NAID 130003381810

Pemphigus, discoid lupus erythematosus, and dermatomyositis during an 8-year follow-up period: a case report

Journal of Oral Science 55(3), 255-258, 2013
NAID 130003366682

症例報告尋常性痤瘡治療に用いられたフルオシノロンアセトニドによると考えられた酒皶様皮膚炎の1例

臨床皮膚科 66(10), 761-764, 2012-09
NAID 40019431168

Related Pictures

★リンクテーブル★

リンク元	「フルオシノロンアセトニド」

「フルオシノロンアセトニド」

Fluocinolone acetonide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	C;
Routes of; administration	Topical
ATC code	C05AA10 (WHO) D07AC04 (WHO) S01BA15 (WHO) S02BA08 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Biological half-life	1.3 to 1.7 hours
Identifiers
	IUPAC name (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one;
CAS Number	67-73-2 ;
PubChem CID	6215;
IUPHAR/BPS	7077;
DrugBank	DB00591 ;
ChemSpider	5980 ;
UNII	0CD5FD6S2M;
KEGG	D01825 ;
ChEBI	CHEBI:31623 ;
ChEMBL	CHEMBL989 ;
ECHA InfoCard	100.000.607
Chemical and physical data
Formula	C24H30F2O6
Molar mass	452.488 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=C\1\C=C5/[C@@](/C=C/1)(C)[C@]2(F)[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F ;
	InChI InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 ; Key:FEBLZLNTKCEFIT-VSXGLTOVSA-N ;
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　　[★]

英: fluocinolone acetonide
ラ: fluocinoloni acetonidum
商: フルコート、フルゾン、フルベアン、フルポロン、ポリシラール、デルモラン、Fluonid, Synalar
関: トリアムシノロン

糖質コルチコイド;強力な抗炎症作用;外用

[1] J S Mills, A. Bowers, Carl Djerassi and H.J. Ringold, Steroids CXXXVII. Synthesis of a New Class of Potent Cortical Hormones. 6α,9α-Difluoro-16α-Hydroxyprednisolone and its Acetonide, Journal of the American Chemical Society, 80, 3399-3404 (1960)

[2] Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Matsumoto T, Young MF, Olsen BR, Kuboki T. Fluocinolone Acetonide is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration. J Bone Miner Res. 2015. http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2502/abstract

[Brady-3] Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J (2016). "Corticosteroid implants for chronic non-infectious uveitis". Cochrane Database Syst Rev. 2: CD010469. doi:10.1002/14651858.CD010469.pub2. PMID 26866343.

v t e Drugs used for diseases of the ear (S02)

Infection	Acetic acid Aluminium acetotartrate Aluminium triacetate (Burow's solution) Boric acid Chloramphenicol Chlorhexidine Ciprofloxacin Clioquinol Gentamicin Hydrogen peroxide Miconazole Neomycin Nitrofurazone Ofloxacin Polymyxin B Rifamycin Tetracycline

Corticosteroids	Betamethasone Dexamethasone Fluocinolone acetonide Hydrocortisone Prednisolone

Analgesics and anesthetics	Lidocaine Cocaine Phenazone

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fluocinolone acetonide