Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/23 03:55:06」(JST)

wiki en

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City.^[1] Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.^[2]

Fluocinolone acetonide intravitreal implants have been used to treat non-infectious uveitis. A systematic review could not determine whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis.^[3]

Flucinolone is a group V (0.025%) or group VI (0.01%) corticosteroid under US classification.

References

^ J S Mills, A. Bowers, Carl Djerassi and H.J. Ringold, Steroids CXXXVII. Synthesis of a New Class of Potent Cortical Hormones. 6α,9α-Difluoro-16α-Hydroxyprednisolone and its Acetonide, Journal of the American Chemical Society, 80, 3399-3404 (1960)
^ Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Matsumoto T, Young MF, Olsen BR, Kuboki T. Fluocinolone Acetonide is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration. J Bone Miner Res. 2015. http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2502/abstract
^ Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J (2016). "Corticosteroid implants for chronic non-infectious uveitis". Cochrane Database Syst Rev. 2: CD010469. PMID 26866343. doi:10.1002/14651858.CD010469.pub2.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ブドウ膜炎：治療 uveitis treatment
2. 肝斑 melasma
3. 思春期および成人における脂漏性皮膚炎 seborrheic dermatitis in adolescents and adults
4. アトピー性皮膚炎（湿疹）の治療 treatment of atopic dermatitis eczema
5. 自己免疫性甲状腺疾患における前脛骨部粘液水腫（甲状腺皮膚症） pretibial myxedema thyroid dermopathy in autoimmune thyroid disease

English Journal

Emerging drugs for diabetic macular edema.

Schwartz SG1, Flynn HW Jr, Scott IU.
Expert opinion on emerging drugs.Expert Opin Emerg Drugs.2014 Sep;19(3):397-405. doi: 10.1517/14728214.2014.938048. Epub 2014 Aug 21.
INTRODUCTION: Diabetic macular edema (DME) is the most common cause of visual impairment due to diabetic retinopathy. The treatment of DME has recently undergone a paradigm shift. Traditionally, photocoagulation was standard treatment, but pharmacologic therapies are becoming increasingly used for t
PMID 25141904

SAFETY AND EFFICACY OF FLUOCINOLONE ACETONIDE INTRAVITREAL IMPLANT (0.59 mg) IN BIRDSHOT RETINOCHOROIDOPATHY.

Bajwa A1, Aziz K, Foster CS.
Retina (Philadelphia, Pa.).Retina.2014 Jul 3. [Epub ahead of print]
PURPOSE:: To report the treatment outcomes of the fluocinolone acetonide intravitreal implant (0.59 mg) in patients with birdshot retinochoroidopathy whose disease is refractory or intolerant to conventional immunomodulatory therapy.METHODS:: A retrospective case series involving 11 birdshot retinoc
PMID 24999722

Ciprofloxacin plus fluocinolone acetonide versus ciprofloxacin alone in the treatment of diffuse otitis externa.

Lorente J1, Sabater F2, Rivas MP3, Fuste J4, Risco J5, Gómez M6.
The Journal of laryngology and otology.J Laryngol Otol.2014 Jul;128(7):591-8. doi: 10.1017/S0022215114001157. Epub 2014 Jul 7.
OBJECTIVE: We aimed to evaluate the clinical efficacy of ciprofloxacin plus fluocinolone acetonide (antibiotic plus corticosteroid) ear drops compared to ciprofloxacin (antibiotic) ear drops in diffuse otitis externa.METHODS: This was a multicentre, randomised, parallel-group, double-blind study inv
PMID 25000552

Related Pictures

Synalar Topical : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD Synalar Simple 0.01 % Cutaneo 40 g. Crema Synalar Solution - FDA prescribing information, side effects and uses Synalar | Fluocinolon | Hormonsalbe | Hautirritationen | Bestellen Synalar Simple 0.025% crema 20 g | Superama a domicilio Synalar Topical : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD

★リンクテーブル★

リンク元	「フルオシノロンアセトニド」

「フルオシノロンアセトニド」

Fluocinolone acetonide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	C;
Routes of; administration	Topical
ATC code	C05AA10 (WHO) D07AC04 (WHO) S01BA15 (WHO) S02BA08 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Biological half-life	1.3 to 1.7 hours
Identifiers
	IUPAC name (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one;
CAS Number	67-73-2 ;
PubChem CID	6215;
IUPHAR/BPS	7077;
DrugBank	DB00591 ;
ChemSpider	5980 ;
UNII	0CD5FD6S2M;
KEGG	D01825 ;
ChEBI	CHEBI:31623 ;
ChEMBL	CHEMBL989 ;
ECHA InfoCard	100.000.607
Chemical and physical data
Formula	C24H30F2O6
Molar mass	452.488 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C\1\C=C5/[C@@](/C=C/1)(C)[C@]2(F)[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F ;
	InChI InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 ; Key:FEBLZLNTKCEFIT-VSXGLTOVSA-N ;
(what is this?) (verify)

　　[★]

英: fluocinolone acetonide
ラ: fluocinoloni acetonidum
商: フルコート、フルゾン、フルベアン、フルポロン、ポリシラール、デルモラン、Fluonid, Synalar
関: トリアムシノロン

糖質コルチコイド;強力な抗炎症作用;外用

[1] J S Mills, A. Bowers, Carl Djerassi and H.J. Ringold, Steroids CXXXVII. Synthesis of a New Class of Potent Cortical Hormones. 6α,9α-Difluoro-16α-Hydroxyprednisolone and its Acetonide, Journal of the American Chemical Society, 80, 3399-3404 (1960)

[2] Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Matsumoto T, Young MF, Olsen BR, Kuboki T. Fluocinolone Acetonide is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration. J Bone Miner Res. 2015. http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2502/abstract

[Brady-3] Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J (2016). "Corticosteroid implants for chronic non-infectious uveitis". Cochrane Database Syst Rev. 2: CD010469. PMID 26866343. doi:10.1002/14651858.CD010469.pub2.

v t e Drugs used for diseases of the ear (S02)
Infection	Acetic acid Aluminium acetotartrate Aluminium triacetate (Burow's solution) Boric acid Chloramphenicol Chlorhexidine Ciprofloxacin Clioquinol Gentamicin Hydrogen peroxide Miconazole Neomycin Nitrofurazone Ofloxacin Polymyxin B Rifamycin Tetracycline
Corticosteroids	Betamethasone Dexamethasone Fluocinolone acetonide Hydrocortisone Prednisolone
Analgesics and anesthetics	Lidocaine Cocaine Phenazone

匿名

検索

案内

案内

Synalar