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a nonsteroidal anti-inflammatory (trade name Meclomen) used to treat arthritis (同)meclofenamate sodium, Meclomen

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/13 15:47:06」(JST)

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Fenamic acid is a molecule which, especially in its ester form, fenamate,^[1]^:458 serves as a parent structure for several non-steroidal anti-inflammatory drugs, including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.^[2]^:235^[3]^:17^[2]

References

^ Gupta, PK. Drug NomenclatureUnited States Adopted Names. Ch 27 in Remington: The Science and Practice of Pharmacy, Vol 1. Eds. David B. Troy, Paul Beringer. Lippincott Williams & Wilkins, 2006 ISBN 9780781746731
^ ^a ^b Sriram D, Yogeeswari P. Medicinal Chemistry, 2nd Edition. Pearson Education India, 2010. ISBN 9788131731444
^ Auburn University course material. Jack DeRuiter, Principles of Drug Action 2, Fall 2002 1: Non-Steroidal Antiinflammatory Drugs (NSAIDS)

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1. 成人女性における原発性月経困難症の治療 treatment of primary dysmenorrhea in adult women

English Journal

Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels.

Thomson SJ1, Hansen A1, Sanguinetti MC2.
The Journal of biological chemistry.J Biol Chem.2015 Jun 5;290(23):14528-35. doi: 10.1074/jbc.M115.653089. Epub 2015 Apr 22.
Slo2 potassium channels have a very low open probability under normal physiological conditions, but are readily activated in response to an elevated [Na(+)]i (e.g. during ischemia). An intracellular Na(+) coordination motif (DX(R/K)XXH) was previously identified in Kir3.2, Kir3.4, Kir5.1, and Slo2.2
PMID 25903137

Efficacy and safety of morniflumate for the treatment of symptoms associated with soft tissue inflammation.

Cremonesi G1, Cavalieri L2.
The Journal of international medical research.J Int Med Res.2015 Jun;43(3):290-302. doi: 10.1177/0300060514567212. Epub 2015 Apr 28.
The effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) for the management of pain in osteoarthritis and other musculoskeletal diseases is well documented. The role of NSAIDs is less clear in the treatment of conditions involving soft tissue inflammation, including the airways, ear-nose-th
PMID 25921871

Role for electrical synapses in shaping the output of coupled peptidergic neurons from Lymnaea.

Beekharry CC1, Zhu GZ1, Magoski NS2.
Brain research.Brain Res.2015 Apr 7;1603:8-21. doi: 10.1016/j.brainres.2015.01.039. Epub 2015 Jan 30.
Electrically coupled neurons communicate through channel assemblies called gap junctions, which mediate the transfer of current from one cell to another. Electrical synapses ensure spike synchronization and reliable transmission, which influences bursting patterns and firing frequency. The present s
PMID 25641041

Japanese Journal

Synthesis of New Nicotinic Acid Derivatives and Their Evaluation as Analgesic and Anti-inflammatory Agents

, , [他],
Chemical and Pharmaceutical Bulletin 61(9), 933-940, 2013
A series of 2-substituted phenyl derivatives of nicotinic acid 4a–l were synthesized and evaluated for their analgesic and anti-inflammatory activities. Compounds including 2-bromophenyl substituent, …
NAID 130003360827

Fenamates Potentiate the α_1-Adrenoceptor-Activated Nonselective Cation Channels in Rabbit Portal Vein Smooth Muscle

, , ,
The Japanese journal of pharmacology 70(1), 81-84, 1996-01-01
The agonistic action of fenamates on the α<SUB>1</SUB>-adrenoceptor-activated cationic current (I<SUB>cat</SUB>) in rabbit portal vein smooth muscle was investigated with the w …
NAID 10005713057

Isolation and Characterization of Human Urinary Metabolites of Meclomen

松木容彦,團純子,福原克治,伊東富晴,南原利夫
Chemical & pharmaceutical bulletin 36(4), 1431-1436, 1988-04-25
… Oxidation occurred at the methyl group at C-3 and/or the aromatic ring in meclomen, yielding the methylol (M-1), dicarboxylic acid (M-2), phenols (M-3 and M-4), 3-hydroxymethylated phenol (M-7), 3-demethylated phenol (M-6) and phenolic dicarboxylic acid (M-8).Among these metabolites, M-1,M-2,M-3 and M-4 are common to fenamate antiinflammatory analgesics. …
NAID 110003626933

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拡張検索	「flufenamate」「meclofenamate」

「flufenamate」

Fenamic acid
Names
	IUPAC name 2-(phenylamino)benzoic acid
	Other names N-phenylanthranilic acid
Identifiers
CAS Number	91-40-7
ChEBI	CHEBI:34756
ChEMBL	ChEMBL23832
ChemSpider	4233
IUPHAR/BPS	4182
Jmol 3D model	Interactive image
PubChem	4386
	InChI InChI=1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16) Key: ZWJINEZUASEZBH-UHFFFAOYSA-N ; InChI=1/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16) Key: ZWJINEZUASEZBH-UHFFFAOYAQ ;
	SMILES C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O ;
Properties
Chemical formula	C13H11NO2
Molar mass	213.23 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

フルフェナム酸

関: flufenamic acid、flufenamic acid aluminium、flufenamic acid aluminum

「meclofenamate」

　　[★]

メクロフェナム酸

関: meclofenamic acid

[1] Gupta, PK. Drug NomenclatureUnited States Adopted Names. Ch 27 in Remington: The Science and Practice of Pharmacy, Vol 1. Eds. David B. Troy, Paul Beringer. Lippincott Williams & Wilkins, 2006 ISBN 9780781746731

[Sriram-2] Sriram D, Yogeeswari P. Medicinal Chemistry, 2nd Edition. Pearson Education India, 2010. ISBN 9788131731444

[3] Auburn University course material. Jack DeRuiter, Principles of Drug Action 2, Fall 2002 1: Non-Steroidal Antiinflammatory Drugs (NSAIDS)

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)

Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡

Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate

Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indomethacin Indomethacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†

Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam

Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ COX-inhibiting nitric oxide donator: Naproxcinod

N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin

Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†

Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap

Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

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fenamate