フェナム酸
WordNet
- a nonsteroidal anti-inflammatory (trade name Meclomen) used to treat arthritis (同)meclofenamate sodium, Meclomen
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/08/13 15:47:06」(JST)
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Fenamic acid
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Names |
IUPAC name
2-(phenylamino)benzoic acid
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Other names
N-phenylanthranilic acid
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Identifiers |
CAS Number
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91-40-7 Y |
ChEBI |
CHEBI:34756 N |
ChEMBL |
ChEMBL23832 N |
ChemSpider |
4233 N |
IUPHAR/BPS
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4182 |
Jmol 3D model |
Interactive image |
PubChem |
4386 |
InChI
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InChI=1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16) N
Key: ZWJINEZUASEZBH-UHFFFAOYSA-N N
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InChI=1/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16)
Key: ZWJINEZUASEZBH-UHFFFAOYAQ
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SMILES
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C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O
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Properties |
Chemical formula
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C13H11NO2 |
Molar mass |
213.23 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is YN ?) |
Infobox references |
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Fenamic acid is a molecule which, especially in its ester form, fenamate,[1]:458 serves as a parent structure for several non-steroidal anti-inflammatory drugs, including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.[2]:235[3]:17[2]
See also
- Ufenamate is another example.
References
- ^ Gupta, PK. Drug NomenclatureUnited States Adopted Names. Ch 27 in Remington: The Science and Practice of Pharmacy, Vol 1. Eds. David B. Troy, Paul Beringer. Lippincott Williams & Wilkins, 2006 ISBN 9780781746731
- ^ a b Sriram D, Yogeeswari P. Medicinal Chemistry, 2nd Edition. Pearson Education India, 2010. ISBN 9788131731444
- ^ Auburn University course material. Jack DeRuiter, Principles of Drug Action 2, Fall 2002 1: Non-Steroidal Antiinflammatory Drugs (NSAIDS)
Prostanoid signaling
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Receptor
(ligands) |
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Enzyme
(inhibitors) |
COX (PTGS) |
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PGD2 synthase |
- Retinoids
- Selenium (selenium tetrachloride, sodium selenite, selenium disulfide)
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PGE synthase |
HQL-79
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PGF synthase |
Bimatoprost
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PGI2 synthase |
Tranylcypromine
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TXA synthase |
- Camonagrel
- Dazmegrel
- Dazoxiben
- Furegrelate
- Isbogrel
- Midazogrel
- Nafagrel
- Nicogrelate
- Ozagrel
- Picotamide
- Pirmagrel
- Ridogrel
- Rolafagrel
- Samixogrel
- Terbogrel
- U63557A
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Others |
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
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See also: Leukotrienergics
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UpToDate Contents
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English Journal
- Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels.
- Thomson SJ1, Hansen A1, Sanguinetti MC2.
- The Journal of biological chemistry.J Biol Chem.2015 Jun 5;290(23):14528-35. doi: 10.1074/jbc.M115.653089. Epub 2015 Apr 22.
- Slo2 potassium channels have a very low open probability under normal physiological conditions, but are readily activated in response to an elevated [Na(+)]i (e.g. during ischemia). An intracellular Na(+) coordination motif (DX(R/K)XXH) was previously identified in Kir3.2, Kir3.4, Kir5.1, and Slo2.2
- PMID 25903137
- Efficacy and safety of morniflumate for the treatment of symptoms associated with soft tissue inflammation.
- Cremonesi G1, Cavalieri L2.
- The Journal of international medical research.J Int Med Res.2015 Jun;43(3):290-302. doi: 10.1177/0300060514567212. Epub 2015 Apr 28.
- The effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) for the management of pain in osteoarthritis and other musculoskeletal diseases is well documented. The role of NSAIDs is less clear in the treatment of conditions involving soft tissue inflammation, including the airways, ear-nose-th
- PMID 25921871
- Role for electrical synapses in shaping the output of coupled peptidergic neurons from Lymnaea.
- Beekharry CC1, Zhu GZ1, Magoski NS2.
- Brain research.Brain Res.2015 Apr 7;1603:8-21. doi: 10.1016/j.brainres.2015.01.039. Epub 2015 Jan 30.
- Electrically coupled neurons communicate through channel assemblies called gap junctions, which mediate the transfer of current from one cell to another. Electrical synapses ensure spike synchronization and reliable transmission, which influences bursting patterns and firing frequency. The present s
- PMID 25641041
Japanese Journal
- Synthesis of New Nicotinic Acid Derivatives and Their Evaluation as Analgesic and Anti-inflammatory Agents
- , , [他],
- Chemical and Pharmaceutical Bulletin 61(9), 933-940, 2013
- A series of 2-substituted phenyl derivatives of nicotinic acid 4a–l were synthesized and evaluated for their analgesic and anti-inflammatory activities. Compounds including 2-bromophenyl substituent, …
- NAID 130003360827
- Fenamates Potentiate the α_1-Adrenoceptor-Activated Nonselective Cation Channels in Rabbit Portal Vein Smooth Muscle
- , , ,
- The Japanese journal of pharmacology 70(1), 81-84, 1996-01-01
- The agonistic action of fenamates on the α<SUB>1</SUB>-adrenoceptor-activated cationic current (I<SUB>cat</SUB>) in rabbit portal vein smooth muscle was investigated with the w …
- NAID 10005713057
- Isolation and Characterization of Human Urinary Metabolites of Meclomen
- 松木 容彦,團 純子,福原 克治,伊東 富晴,南原 利夫
- Chemical & pharmaceutical bulletin 36(4), 1431-1436, 1988-04-25
- … Oxidation occurred at the methyl group at C-3 and/or the aromatic ring in meclomen, yielding the methylol (M-1), dicarboxylic acid (M-2), phenols (M-3 and M-4), 3-hydroxymethylated phenol (M-7), 3-demethylated phenol (M-6) and phenolic dicarboxylic acid (M-8).Among these metabolites, M-1,M-2,M-3 and M-4 are common to fenamate antiinflammatory analgesics. …
- NAID 110003626933
Related Links
- Fenamate - chemical information, properties, structures, articles, patents and more chemical data. Enter your search term above and find: · CAS Numbers · Molecular Formulas · Synonyms · Sites/Web Search · Suppliers · Resources
- fen·a·mate (fenґə māt) any of a class of analgesic and antiinflammatory agents derived from N phenylanthranilic acid ... Look at other dictionaries: Nicotinic agonist — A nicotinic agonist is a drug which enhances the action at the ...
Related Pictures
★リンクテーブル★
[★]
フルフェナム酸
- 関
- flufenamic acid、flufenamic acid aluminium、flufenamic acid aluminum
[★]
メクロフェナム酸
- 関
- meclofenamic acid