WordNet

a nonsteroidal anti-inflammatory (trade name Meclomen) used to treat arthritis (同)meclofenamate sodium, Meclomen
street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/17 22:10:53」(JST)

wiki en

Meclofenamic acid (meclofenamate sodium, brand Meclomen) is a drug used for joint, muscular pain, arthritis and dysmenorrhea.^[1] It is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs and was approved by the FDA in 1980.^[2] Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.^[3]

Scientists led by Claude Winder from Parke-Davis invented meclofenamate sodium in 1964, along with fellow members of the class, mefenamic acid in 1961 and flufenamic acid in 1963.^[4]^:718

Patents on the drug expired in 1985^[5]^:295 and several generics were introduced in the US, but as of July 2015 only Mylan still sold it.^[6]^[7]

It is not widely used in humans as it a high rate (30-60%) rate of gastrointestinal side effects.^[8]^:310

Use in horses

Meclofenamic acid is sold under the trade name "Arquel" for use in horses, and is administered as an oral granual form at a dose of 2.2 mg/kg/day.^[9] It has a relatively slow onset of action, taking 36–48 hours for full effect,^[10] and is most useful for treatment of chronic musculoskeletal disease.^[11] It has been found to be beneficial for the treatment of navicular syndrome, laminitis, and osteoarthritis,^[10] in some cases having a more profound effect than the commonly-used NSAID phenylbutazone.^[12] However, due to cost, it is not routinely used in practice. Toxicity due to excessive dosage is similar to that of phenylbutazone, including depression, anorexia, weight loss, edema, diarrhea, oral ulceration, and decreased hematocrit.^[12]

References

^ http://www.medicinenet.com/meclofenamate/article.htm
^ FDA Meclomen page at FDA Page accessed July 3, 2015
^ NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015
^ Whitehouse M. Drugs to Treat Inflammation: A Historical Overview. pp 707-729 in Frontiers in Medicinal Chemistry , Volume 4. Eds Rahman A, et al. Bentham Science Publishers, 2009 ISBN 9781608052073
^ United States. Congress. Office of Technology Assessment Pharmaceutical R & D: Costs, Risks & Rewards DIANE Publishing, 1993 ISBN 9780788104688
^ FDA Meclofenamate sodium ANDAs at FDA Page accessed July 3, 2015
^ FDA Mylan label for meclofenamate sodium Revised: October 2013, Accessed July 3, 2015
^ Jeffrey K. Aronson. Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs. Elsevier, 2009 ISBN 9780080932941
^ McIlwraith CW, Frisbie DD, Kawcak CE. Nonsteroidal Anti-Inflammatory Drugs. Proc. AAEP 2001 (47): 182-187.
^ ^a ^b Cotter GH, Riley WF, Beck CC, Coppock RW. Arquel (Cl- 1583). A new nonsteroidal anti-inflammatory drug for horses, in Proceedings. Am Assoc Equine Practnr 1973;19: 81–90.
^ Snow DH, Baxter P, Whiting B. The pharmacokinetics of meclofenamic acid in the horse. J Vet Pharmacol Ther 1981; 4:147–156.
^ ^a ^b Lees P, Higgins AJ. Clinical pharmacology in therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Vet J 1985;17:83–96.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 非選択性非ステロイド性抗炎症剤（NSAIDs）：心血管系への有害作用 nonselective nsaids adverse cardiovascular effects
2. 非ステロイド性抗炎症剤（NSAIDs）中毒 nonsteroidal antiinflammatory drug nsaid poisoning
3. 成人女性における原発性月経困難症の治療 treatment of primary dysmenorrhea in adult women
4. 妊娠中および授乳中のリウマチ性疾患における抗炎症剤および免疫抑制剤の使用 use of antiinflammatory and immunosuppressive drugs in rheumatic diseases during pregnancy and lactation
5. 胎児の酸塩基の生理学 fetal acid base physiology

English Journal

Role for electrical synapses in shaping the output of coupled peptidergic neurons from Lymnaea.

Beekharry CC1, Zhu GZ1, Magoski NS2.
Brain research.Brain Res.2015 Apr 7;1603:8-21. doi: 10.1016/j.brainres.2015.01.039. Epub 2015 Jan 30.
Electrically coupled neurons communicate through channel assemblies called gap junctions, which mediate the transfer of current from one cell to another. Electrical synapses ensure spike synchronization and reliable transmission, which influences bursting patterns and firing frequency. The present s
PMID 25641041

Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish.

Ma Y1, Juntti SA2, Hu CK2, Huguenard JR1, Fernald RD3.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Mar 24;112(12):3805-10. doi: 10.1073/pnas.1421851112. Epub 2015 Mar 9.
Initiating and regulating vertebrate reproduction requires pulsatile release of gonadotropin-releasing hormone (GnRH1) from the hypothalamus. Coordinated GnRH1 release, not simply elevated absolute levels, effects the release of pituitary gonadotropins that drive steroid production in the gonads. Ho
PMID 25775522

Japanese Journal

Effect of <i>N</i>-Phenylanthranilic Acid Scaffold Nonsteroidal Anti-inflammatory Drugs on the Mitochondrial Permeability Transition

Biological and Pharmaceutical Bulletin 39(2), 278-284, 2016
NAID 130005122365

Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro

Neuropharmacology 49(7), 1088-1099, 2005-12
NAID 120001132994

Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties

Mol Pharmacol 67, 1053-1066, 2005
NAID 30003139291

Related Pictures

★リンクテーブル★

リンク元	「メクロフェナム酸」「meclofenamate」

「メクロフェナム酸」

Meclofenamic acid
Systematic (IUPAC) name
	2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
Clinical data
Trade names	Meclomen
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Identifiers
CAS Registry Number	644-62-2
ATC code	M01AG04 M02AA18
PubChem	CID: 4037
IUPHAR/BPS	7219
DrugBank	DB00939
ChemSpider	3897
UNII	48I5LU4ZWD
KEGG	D02341
ChEBI	CHEBI:6710
ChEMBL	CHEMBL509
Chemical data
Formula	C14H11Cl2NO2
Molecular mass	296.14864 g/mol