WordNet
- of agriculture; increasing productivity by using large areas with minimal outlay and labor; "producing wheat under extensive conditions"; "agriculture of the extensive type"
- large in spatial extent or range or scope or quantity; "an extensive Roman settlement in northwest England"; "extended farm lands"; "surgeons with extended experience"; "they suffered extensive damage" (同)extended
- produce by metabolism (同)metabolise
PrepTutorEJDIC
- (場所などが)広い,広大な / (領域・効果などが)広範囲にわたる;手広い / (量・額・程度・数などが)大きい,膨大な
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- 1. 進展型小細胞肺癌：初期マネージメント extensive stage small cell lung cancer initial management
- 2. 小児における扁桃摘出（アデノイド切除同時施行例を含む）：術後ケアおよび合併症 tonsillectomy with or without adenoidectomy in children postoperative care and complications
- 3. 乳房温存療法 breast conserving therapy
- 4. 小細胞肺癌患者に対する予防的全脳照射 prophylactic cranial irradiation for patients with small cell lung cancer
- 5. 小細胞肺癌の病理および病期分類 pathobiology and staging of small cell carcinoma of the lung
English Journal
- Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel.
- Doll JA1, Neely ML2, Roe MT3, Armstrong PW4, White HD5, Prabhakaran D6, Winters KJ7, Duvvuru S7, Sundseth SS8, Jakubowski JA7, Gurbel PA9, Bhatt DL10, Ohman EM3, Fox KA11; TRILOGY ACS Investigators.
- Journal of the American College of Cardiology.J Am Coll Cardiol.2016 Mar 1;67(8):936-47. doi: 10.1016/j.jacc.2015.12.036.
- BACKGROUND: Certain alleles of the CYP2C19 gene are associated with higher platelet reactivity and increased ischemic events among patients treated with clopidogrel. However, the relationship of CYP2C19 genotype and outcomes in medically managed patients with acute coronary syndromes (ACS) is not kn
- PMID 26916483
- Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial.
- St Jean PL1, Xue Z2, Carter N3, Koh GC4, Duparc S5, Taylor M6, Beaumont C7, Llanos-Cuentas A8, Rueangweerayut R9, Krudsood S10, Green JA11, Rubio JP12.
- Malaria journal.Malar J.2016 Feb 18;15(1):97. doi: 10.1186/s12936-016-1145-5.
- BACKGROUND: Tafenoquine (TQ) and primaquine (PQ) are 8-aminoquinolines (8-AQ) with anti-hypnozoite activity against vivax malaria. PQ is the only FDA-approved medicine for preventing relapsing Plasmodium vivax infection and TQ is currently in phase 3 clinical trials for the same indication. Recent s
- PMID 26888075
- Impact of Pharmacogenetic Markers of CYP2D6 and DRD2 on Prolactin Response in Risperidone-Treated Thai Children and Adolescents With Autism Spectrum Disorders.
- Sukasem C1, Hongkaew Y, Ngamsamut N, Puangpetch A, Vanwong N, Chamnanphon M, Chamkrachchangpada B, Sinrachatanant A, Limsila P.
- Journal of clinical psychopharmacology.J Clin Psychopharmacol.2016 Feb 11. [Epub ahead of print]
- OBJECTIVE: The aim of the study was to identify the impact of pharmacogenetic markers associated with prolactin concentration in risperidone-treated children and adolescents with autism spectrum disorders.METHODS: One hundred forty-seven children and adolescents with autism, aged 3 to 19 years, rece
- PMID 26872113
Japanese Journal
- A Randomized Study of the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Clopidogrel in Three Different CYP2C19 Genotype Groups of Healthy Japanese Subjects
- Kobayashi Masahiko,Kajiwara Miyuki,Hasegawa Setsuo
- Journal of Atherosclerosis and Thrombosis advpub(0), 2015
- … Eligible subjects were stratified by dose regimen (300 mg loading dose of clopidogrel on day 1 followed by a 75 mg maintenance dose from days 2 to 7 or a 600 mg loading dose of clopidogrel on day 1 followed by a 150 mg maintenance dose from days 2 to 7) and CYP2C19 metabolizer group [extensive metabolizers (EMs), intermediate metabolizers (IMs), and poor metabolizers (PMs)]. …
- NAID 130005075773
- 開心術後 Warfarin と PPI の相互作用による合併症回避のためのリスクマネージメントを目標としたゲノム解析
- 木村 玄,秦 光賢,塩野 元美,関野 久邦
- 日本心臓血管外科学会雑誌 43(4), 163-169, 2014
- … 代謝過程を共有するため，INR（International Normalizing Ratio）が急上昇し出血合併症のリスクとなる．［対象］CYP2C19の遺伝子亜型は代謝の早いEM（Extensive Metabolizer）型，遅いPM（Poor Metabolizer）型，中間のIM（Intermediate Metabolizer）型の3種が存在するが，WF，PPIの競合作用における遺伝子の関与については不明である．［結果］われわれは，PPIの種類とCYP2C19遺伝子亜型 …
- NAID 130004679591
- A Case-report of Unpredictable and Massive Voriconazole Intoxication in a Patient with Extensive CYP2C19 and CYP2C9 Polymorphisms
- LEMAITRE Florian,BARBAZ Mathilde,SCAILTEUX Lucie-Marie,UHEL Fabrice,TADIÉ Jean-Marc,VERDIER Marie-Clémence,BELLISSANT Eric
- Drug Metabolism and Pharmacokinetics 28(5), 439-441, 2013
- … This case-report describes a massive voriconazole (VRZ) intoxication in a patient with a poor metabolizer profile, highlighted by low plasma main metabolite concentrations (N-oxide voriconazole), despite an extensive genetic profile for CYP2C19 and CYP2C9. …
- NAID 130004933546
Related Links
- EM、PM（extensive metabolizer, poor metabolizer） ある薬物代謝酵素において、高い代謝能を有する人をEM、代謝能が欠損または著しく低い人をPMという。遺伝子多型が原因となっていることが多い。 （北海道TDM研究会「TDM ...
- ・EM(extensive metabolizer）群 ： CYP2C19 に変異をもたない通常活性群 ・IM(intermediate metabolizer）群 ： CYP2C19 に変異を含む酵素活性が減少している群 ・PM（poor metabolizer）群 ： CYP2C19 に変異を含む酵素活性が ...
Related Pictures
★リンクテーブル★
| リンク元 | 「ultra-rapid metabolizers」「高代謝群」 |
| 関連記事 | 「extensive」「metabolize」 |
「ultra-rapid metabolizers」
- 同
- UM
- 関
- extensive metabolizer EM, poor metabolizer PM, inter-mediate metabolizer, IM
- 特定の薬物の代謝が異常に早い人
「高代謝群」
「extensive」
- adj.
- 広範囲な、広範な(⇔intensive)、大規模な。詳細な。長い。完璧な、徹底的な。(医)拡張性の
- 大量の。大規模な。多数の
- 関
- broad、detail、detailed、extensively、grand、in detail、large scale、large-scale、on a large scale、precise、ubiquitous、ubiquitously、wide、widely、widespread
「metabolize」
- vt.
- 新陳代謝させる
- vi.
- 新陳代謝する