- 関
- glutamate agonist
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- (biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
- a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
- someone involved in a contest or battle (as in an agon)
- pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
- the radical -NH2 (同)amino_group
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2019/08/27 04:11:56」(JST)
[Wiki en表示]
An excitatory amino acid receptor agonist, or glutamate receptor agonist, is a chemical substance which agonizes one or more of the glutamate receptors.[1]
Examples include:
- AMPA
- Glutamic acid
- Ibotenic acid
- Kainic acid
- N-Methyl-D-aspartic acid
- Quisqualic acid
See also
- Excitatory amino acid receptor antagonist
- Excitatory amino acid reuptake inhibitor
References
- ^ Excitatory+amino+acid+agonists at the US National Library of Medicine Medical Subject Headings (MeSH)
External links
- MeSH list of agents 82018690
Pharmacomodulation |
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Types |
- ♦ Enzyme: Inducer
- Inhibitor
- ♦ Ion channel: Opener
- Blocker
- ♦ Receptor: Agonist
- Partial agonist
- Antagonist
- Inverse agonist
- Positive allosteric modulator (PAM)
- Negative allosteric modulator (NAM)
- ♦ Transporter [Reuptake vs Efflux]: Enhancer (RE)
- Inhibitor (RI)
- Releaser (RA)
- ♦ Miscellaneous: Precursor
- Cofactor
|
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Classes | Enzyme | see Enzyme inhibition |
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Ion channel | See Ion channel modulators |
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Receptor & transporter | BA/M | Adrenergic |
- Adrenergic receptor agonist (α
- β (1
- 2))
- Adrenergic receptor antagonist (α (1
- 2)
- β)
- Norepinephrine reuptake inhibitor (NRI)
|
---|
Dopaminergic |
- Dopamine receptor agonist
- Dopamine receptor antagonist
- Dopamine reuptake inhibitor (DRI)
|
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Histaminergic |
- Histamine receptor agonist
- Histamine receptor antagonist (H1
- H2
- H3)
|
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Serotonergic |
- Serotonin receptor agonist
- Serotonin receptor antagonist (5-HT3)
- Serotonin reuptake inhibitor (SRI)
|
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|
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AA | GABAergic |
- GABA receptor agonist
- GABA receptor antagonist
- GABA reuptake inhibitor (GRI)
|
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Glutamatergic |
- Glutamate receptor agonist (AMPA)
- Glutamate receptor antagonist (NMDA)
- Glutamate reuptake inhibitor
|
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|
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Cholinergic |
- Acetylcholine receptor agonist (Muscarinic
- Nicotinic)
- Acetylcholine receptor antagonist (Muscarinic
- Nicotinic (Ganglionic
- Muscular))
|
---|
Cannabinoidergic |
- Cannabinoid receptor agonist
- Cannabinoid receptor antagonist
- Endocannabinoid enhancer (eCBE)
- Endocannabinoid reuptake inhibitor (eCBRI)
|
---|
Opioidergic |
- Opioid modulator
- Opioid receptor agonist
- Opioid receptor antagonist
- Enkephalinase inhibitor
|
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Other |
- Adenosine reuptake inhibitor (AdoRI)
- Angiotensin II receptor antagonist
- Endothelin receptor antagonist
- NK1 receptor antagonist
- Vasopressin receptor antagonist
|
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|
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Miscellaneous |
- Cofactor (see Enzyme cofactors)
- Precursor (see Amino acids)
|
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|
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Glutamate receptor modulators |
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Metabotropic glutamate receptor modulators |
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Group I | mGluR1 |
- Agonists: ACPD
- DHPG
- Glutamate
- Ibotenic acid
- Quisqualic acid
- Ro01-6128
- Ro67-4853
- Ro67-7476
- VU-71
- Theanine
- Antagonists: BAY 36-7620
- CPCCOEt
- Cyclothiazide
- LY-367,385
- LY-456,236
- MCPG
- NPS-2390
|
---|
mGluR5 |
- Agonists: ACPD
- ADX-47273
- CDPPB
- CHPG
- DFB
- DHPG
- Glutamate
- Ibotenic acid
- Quisqualic acid
- VU-1545
- Antagonists: CTEP
- DMeOB
- LY-344,545
- Mavoglurant
- MCPG
- NPS-2390
- Remeglurant
- SIB-1757
- SIB-1893; Negative allosteric modulators: Basimglurant
- Dipraglurant
- Fenobam
- GRN-529
- MPEP
- MTEP
- Raseglurant
|
---|
|
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Group II | mGluR2 |
- Agonists: BINA
- CBiPES
- DCG-IV
- Eglumegad
- Glutamate
- Ibotenic acid
- LY-379,268
- LY-404,039 (pomaglumetad)
- LY-487,379
- LY-566,332
- MGS-0028
- Pomaglumetad methionil (LY-2140023)
- Talaglumetad; Positive allosteric modulators: JNJ-40411813 (ADX-71149)
- Antagonists: APICA
- CECXG
- EGLU
- HYDIA
- LY-307,452
- LY-341,495
- MCPG
- MGS-0039
- PCCG-4; Negative allosteric modulators: Decoglurant
- RO4491533
|
---|
mGluR3 |
- Agonists: CBiPES
- DCG-IV
- Eglumegad
- Glutamate
- Ibotenic acid
- LY-379,268
- LY-404,039 (pomaglumetad)
- LY-487,379
- MGS-0028
- Pomaglumetad methionil (LY-2140023)
- Talaglumetad
- Antagonists: APICA
- CECXG
- EGLU
- HYDIA
- LY-307,452
- LY-341,495
- MCPG
- MGS-0039; Negative allosteric modulators: Decoglurant
- RO4491533
|
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|
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Group III | mGluR4 |
- Agonists: Glutamate
- L-AP4
- PHCCC
- VU-001,171
- VU-0155,041; Positive allosteric modulators: Foliglurax
- MPEP
- Antagonists: CPPG
- MAP4
- MPPG
- MSOP
- MTPG
- UBP-1112
|
---|
mGluR6 |
- Agonists: Glutamate
- L-AP4
- Antagonists: CPPG
- MAP4
- MPPG
- MSOP
- MTPG
- UBP-1112
|
---|
mGluR7 |
- Agonists: AMN082
- Glutamate
- L-AP4
- Antagonists: CPPG
- MAP4
- MMPIP
- MPPG
- MSOP
- MTPG
- UBP-1112
|
---|
mGluR8 |
- Agonists: DCPG
- Glutamate
- L-AP4
- Antagonists: CPPG
- MAP4
- MPPG
- MSOP
- MTPG
- UBP-1112
|
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|
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators |
|
UpToDate Contents
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English Journal
- Protocadherin 10 alters γ oscillations, amino acid levels, and their coupling; baclofen partially restores these oscillatory deficits.
- Port RG1, Gajewski C2, Krizman E3, Dow HC2, Hirano S4, Brodkin ES2, Carlson GC2, Robinson MB5, Roberts TPL6, Siegel SJ7.
- Neurobiology of disease.Neurobiol Dis.2017 Dec;108:324-338. doi: 10.1016/j.nbd.2017.08.013. Epub 2017 Aug 24.
- PMID 28844789
- Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice.
- Bao H1, Ran P1, Sun L1, Hu W2, Li H1, Xiao C1, Zhu K1, Du J1.
- Pharmaceutical biology.Pharm Biol.2017 Dec;55(1):299-305.
- PMID 27937670
- Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
- Gulchina Y1, Xu SJ2, Snyder MA1, Elefant F2, Gao WJ1.
- Journal of neurochemistry.J Neurochem.2017 Nov;143(3):320-333. doi: 10.1111/jnc.14101. Epub 2017 Sep 5.
- PMID 28628228
Japanese Journal
- 25 ダイシハーベイン構造類縁体を結合したグルタミン酸受容体の結晶構造解析(口頭発表の部)
- 海野 昌喜,篠原 正将,高山 昴一郎,酒井 隆一,佐々木 誠,齋藤 正男
- 天然有機化合物討論会講演要旨集 (50), 173-178, 2008-09-01
- … Dysiherbaine (DH) and its congener neodysiherbaine A (NDH) are naturally occurring excitatory amino acids with high-affinity and subunit-selectivity for kainate type ionotropic glutamate receptors, especially GluR5 and GluR6 subunits. … DH and NDH form unique hydrogen-bonding and hydrophobic interactions with the amino acid residues in the binding-cleft by excluding the water molecules, which mediate hydrogen bonding interactions with glutamate. …
- NAID 110007066761
- The mapped pattern of kainate on blood pressure responses is similar to that of L-proline in the ventrolateral medulla of the rat
- Takemoto Yumi,タケモト ユミ,竹本 裕美
- Neuroscience Letters 425(1), 12-17, 2007-09
- … Kainate is an excitatory amino acid receptor agonist with a structure similar to the amino acid L-proline. …
- NAID 120000875827
- Endothelin-1-induced Barrel Rotation : No Direct Modulation of Rat Medial Vestibular Nucleus Neurone Activity by Endothelin-1
- 河内 明夫,柴田 由香里,山田 勝士,デュティア マイヤンク,本屋 敏郎
- Equilibrium research 66(1), 9-16, 2007-02-01
- … N-methyl-D-aspartate (NMDA, 1-10 μg), an excitatory amino acid, and muscimol (1-10 μg), a GABAA receptor agonist, also evoked barrel rotation. … Bath application of NMDA and muscimol on the spontaneous tonic discharge of medial vestibular nucleus (MVN) neurones in rats, showed excitatory and inhibitory responses, respectively. …
- NAID 10021289982
Related Links
- 1. Pharm Acta Helv. 2000 Mar;74(2-3):221-9. Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications. Trist DG. Glaxo Wellcome Medicines Research Centre, Verona, Italy. Glutamic ...
- ELSEVIER Pharmaceutica Acta Helvetiae 74 (2000) 221-229 PHARMACEUTICA ACTA HELVETIAE www. elsevier.corn/locate / pharmactahelv Excitatory amino acid agonists and antagonists" pharmacology and therapeutic ...
Related Pictures
★リンクテーブル★
[★]
- 関
- excitatory amino acid agonist
[★]
- 英
- excitatory amino acid agonist
- 関
- グルタミン酸作用薬、グルタミン酸受容体刺激薬、興奮性アミノ酸受容体刺激薬
[★]
- 英
- excitatory amino acid agonist
- 関
- 興奮性アミノ酸アゴニスト、グルタミン酸作用薬、グルタミン酸受容体刺激薬
[★]
- 関
- excitability、excitable、excitation、excite、excitement、exciting、excito、fire