WordNet
- a way of doing something, especially a systematic way; implies an orderly logical arrangement (usually in steps)
- a stable situation in which forces cancel one another
- a sensory system located in structures of the inner ear that registers the orientation of the head (同)labyrinthine sense, vestibular sense, sense of balance, sense_of_equilibrium
- separation of substances in solution by means of their unequal diffusion through semipermeable membranes
PrepTutorEJDIC
- 〈C〉(特に秩序だった)(…の)『方法』,方式《+『of』+『名』(do『ing』)》 / 〈C〉〈U〉(思考行・行為・行動の)きちょうめんさ;秩序,筋道
- (力・勢力・作用などの)釣り合い,均衡;(心の)平静
- 透析(コロイド溶液を半透膜で分離すること)
UpToDate Contents
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- 1. 腹膜透析の妥当性 adequacy of peritoneal dialysis
- 2. 透析の方法および患者の転帰 dialysis modality and patient outcome
- 3. 腹膜透析液 peritoneal dialysis solutions
- 4. 慢性腹膜透析の治療法の選択 choosing a modality for chronic peritoneal dialysis
- 5. 小児における慢性腹膜透析 chronic peritoneal dialysis in children
English Journal
- Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the gamma-secretase inhibitor RO4929097.
- Wu J, Lorusso PM, Matherly LH, Li J.SourceOncology, Karmanos Cancer Institute, Wayne State University.
- Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2012 Feb 20. [Epub ahead of print]
- PURPOSE: Understanding of plasma protein binding will provide mechanistic insights into drug interactions or unusual pharmacokinetic properties. This study investigated RO4929097 binding in plasma and its implications for the pharmacokinetics and pharmacodynamics of this compound.EXPERIMENTAL DESIGN
- PMID 22351688
- Studies on the binding of rhaponticin with human serum albumin by molecular spectroscopy, modeling and equilibrium dialysis.
- Sun Y, Ji Z, Liang X, Li G, Yang S, Wei S, Zhao Y, Hu X, Fan J.SourceSchool of Chemical Engineering, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China.
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2012 Feb 15;87:171-8. Epub 2011 Nov 22.
- Rhaponticin (RHA) possesses a variety of pharmacological activities including potent antitumor, antitumor-promoting, antithrombotic, antioxidant and vasorelaxant effects. In the solvation effect, RHA exhibited bathochromic shift in emission spectra with the increasing solvent polarity. The binding b
- PMID 22169567
- Methylene diphosphonate-conjugated adriamycin liposomes: preparation, characteristics, and targeted therapy for osteosarcomas in vitro and in vivo.
- Wu D, Wan M.SourceKey Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China, wudaocheng@mail.xjtu.edu.cn.
- Biomedical microdevices.Biomed Microdevices.2012 Jan 26. [Epub ahead of print]
- Methylenediphosphonate (MDP)-conjugated adriamycin liposomes (MDP-LADMs) were prepared using mild dynamic dialysis equilibrium method, and their targeted therapeutic effects against osteosarcomas and metastatic SOSP-M lung nodules were evaluated in vivo. The drug loading and encapsulation efficiency
- PMID 22278099
Japanese Journal
- In Vitro Assessment of Plasma Protein Binding of 20(R)-Ginsenoside Rh2 by Equilibrium Dialysis and LC-MS Analysis : A Case of Species Differences(Pharmacology)
- GU Yi,WANG Guangji,SUN Jianguo,JIA Yuanwei,XU Meijuan,WANG Wei
- Biological & pharmaceutical bulletin 29(5), 951-956, 2006-05-01
- … To support its pharmacokinetic study which was essential for the pre-clinical research for new drug development, in this paper, 20(R)-Rh2 plasma protein binding was assessed in vitro at four concentration levels (50, 100, 200, 400ng/ml) both in rat and human plasma using equilibrium dialysis and followed by LC-MS analysis. … The method was optimized against some influencing factors during both experimental procedures. …
- NAID 110005602220
- 創薬における探索薬物動態スクリーニング(II) : 代謝スクリーニングにおけるin vitroとin vivoの相関性の検討
- 小村 弘,松田 健一,茂本 友貴枝,河原 亥一郎,阿野 理恵子,村山 洋子,森脇 俊哉,吉田 長弘
- 藥學雜誌 125(1), 131-139, 2005-01-01
- 肝臓での代謝安定性は経口吸収性とともに生体内利用率に影響する重要な因子であり, その最適化は多くのプロジェクトにおける最重要課題の1つである. 一般に代謝試験には肝ミクロソーム系又は単離肝細胞系が用いられている. 肝細胞系はphaseI及びII代謝活性, さらに肝取り込みや胆汁排泄に関与する膜輸送系を有しており, 開発候補品を初め薬物の詳細な代謝検討に使用されている.しかし非凍結及び凍結ヒト肝細胞 …
- NAID 110003666160
- 創薬における探索薬物動態スクリーニング(I) : 幅広い物性を有する化合物のための吸収評価系の確立
- 小村 弘,河原 亥一郎,茂本 友貴枝,松田 健一,阿野 理恵子,村山 洋子,森脇 俊哉,吉田 長弘
- 藥學雜誌 125(1), 121-130, 2005-01-01
- 経口吸収性は生体内利用率に影響する重要なファクターの1つであり, ヒトでの低い吸収率さらにはその個体間の大きなバラツキは, 開発候補品のディベロッパビリティーを大きく低下させる. 近年コンビナトリアルケミストリー及びハイスループットスクリーニング(HTS)の導入は幅広い生物学的ターゲットに対して効率的にリード化合物の創出を可能にしてきたが, リード化合物の経口吸収性を初め体内動態に関わる物性を悪化 …
- NAID 110003666159
Related Links
- equilibrium dialysis n. A method for determining the association constants for hapten-antibody reactions, by placing hapten and antibody in compartments separated by a semipermeable membrane, thereby allowing hapten to diffuse ...
- 1. J Pharm Sci. 2001 May;90(5):580-87. Development of a high throughput equilibrium dialysis method. Kariv I(1), Cao H, Oldenburg KR. Author information: (1)Leads Discovery Department, Dupont Pharmaceuticals ...
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★リンクテーブル★
| リンク元 | 「平衡透析」「平衡透析法」 |
| 関連記事 | 「method」「equilibrium」 |
「平衡透析」
「平衡透析法」
「method」
- n.
- 関
- assay、fashion、law、manner、means、method for measurement、-metry、mode、procedure、process、system、technique、way
「equilibrium」
- n.
- 平衡、平衡状態、平衡感覚