WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/13 10:47:01」(JST)

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Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.^[1] It is highly selective for the H₁ receptor and does not cross the blood-brain-barrier.^[2]

References

^ Pradhan, S; Abhishek, K; Mah, F (2009). "Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects". Expert opinion on drug metabolism & toxicology 5 (9): 1135–40. doi:10.1517/17425250903117284. PMID 19630694.
^ Walther G, Daniel H, Bechtel WD, Brandt K (April 1990). "New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine". Arzneimittel-Forschung 40 (4): 440–6. PMID 1972625.

External links

Official U.S. website of Elestat

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UpToDate Contents

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1. アレルギー性結膜炎：マネージメント allergic conjunctivitis management
2. 春季カタル vernal keratoconjunctivitis
3. アレルギー性鼻炎の薬物療法 pharmacotherapy of allergic rhinitis
4. 患者情報：結膜炎（ピンクアイ）（詳細） conjunctivitis pinkeye beyond the basics

English Journal

Pharmacological Characterization of Adenosine Receptors on Isolated Human Bronchi.

Calzetta L, Spina D, Cazzola M, Page CP, Facciolo F, Rendina EA, Matera MG.SourceInternal Medicine, University of Rome "Tor Vergata", Rome, Italy; The Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, United Kingdom.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2011 Jun 23. [Epub ahead of print]
Rationale: Adenosine induces airways obstruction in asthmatic subjects but the receptor subtype responsible remains unknown. Objectives: To determine the pharmacological profile of adenosine receptor subtypes mediating contraction and to investigate the mechanism in normal and passively sensitized h
PMID 21700958

Octopamine and occupancy: an aminergic mechanism for intruder-resident aggression in crickets.

Rillich J, Schildberger K, Stevenson PA.SourceInstitut fur Neurobiologie, Freie Universitat Berlin, Konigin-Luise-Str. 28-30, D-14195 Berlin, Germany.
Proceedings. Biological sciences / The Royal Society.Proc Biol Sci.2011 Jun 22;278(1713):1873-80. Epub 2010 Nov 24.
Aggression is a behavioural strategy for securing resources (food, mates and territory) and its expression is strongly influenced by their presence and value. While it is known that resource holders are generally highly aggressive towards intruding consexuals and usually defeat them, the underlying
PMID 21106592

Japanese Journal

アンギオテンシンII受容体拮抗薬が誘因と推察された舌・口底部の血管性浮腫の1例

坂元亮一,上川善昭,永山知宏,杉原一正
歯科薬物療法 29(1), 21-24, 2010-04-01
… She visited an emergency hospital, and was prescribed serrapeptase, a complex of betamethasone and chlorpheniramine maleate, and epinastine hydrochloride. …
NAID 10026132690

薬剤の臨床小児アトピー性皮膚炎に対するエピナスチン塩酸塩ドライシロップの有用性

古川福実,吉田晃
小児科診療 72(1), 188-198, 2009-01
NAID 40016391265

「エピナスチン」

Epinastine
Systematic (IUPAC) name
	(RS)-3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
Clinical data
Trade names	Alesion, Elestat, Purivist, Relestat
AHFS/Drugs.com	monograph
MedlinePlus	a604011
Pregnancy; category	C;
Routes of; administration	Eye drops
Pharmacokinetic data
Protein binding	64%
Biological half-life	12 hours
Identifiers
CAS Registry Number	80012-43-7
ATC code	R06AX24 S01GX10
PubChem	CID: 3241
IUPHAR/BPS	7176
DrugBank	DB00751
ChemSpider	3128
UNII	Q13WX941EF
KEGG	D07900
ChEBI	CHEBI:51032
ChEMBL	CHEMBL1106
Chemical data
Formula	C16H15N3
Molecular mass	249.311 g/mol
	SMILES N\4=C(\N3c1c(cccc1)Cc2c(cccc2)C3C/4)N ;
	InChI InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18) ; Key:WHWZLSFABNNENI-UHFFFAOYSA-N ;
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