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1. ステロイドの全身投与の主な副作用major side effects of systemic glucocorticoids [show details]
… understood. Nongenomic effects of glucocorticoids include rapid, nonspecific interactions of glucocorticoids with cellular membranes, nongenomic effects medicated by cytosolic glucocorticoid receptors, and specific …
2. 免疫系に対するステロイドの影響glucocorticoid effects on the immune system [show details]
… downregulated in response to glucocorticoids . This effect, coupled with the effect of glucocorticoids on dendritic cells, may account for the significant impact of glucocorticoids on acquired immunity. However …
3. ステロイドの薬理学的使用pharmacologic use of glucocorticoids [show details]
…influence both the therapeutic and adverse effects of glucocorticoids will be reviewed here, including the biologic potency, pharmacokinetic properties of the glucocorticoid, daily dose, timing of doses during …
4. ステロイド性骨粗鬆症の臨床的特徴と評価clinical features and evaluation of glucocorticoid induced osteoporosis [show details]
…prevention and treatment of glucocorticoid-induced osteoporosis are presented separately. The deleterious effects of glucocorticoid excess on bone result from direct effects on osteoblasts, osteocytes …
5. ステロイド用量の決定因子determinants of glucocorticoid dosing [show details]
… The determinants of glucocorticoid dosing include: Pharmacokinetics of the different drug preparations; Effects of underlying disorders on drug kinetics; Interactions of glucocorticoids with concurrently …

English Journal

Modulation of endocrine nuclear receptor activities by polyaromatic compounds present in fractionated extracts of diesel exhaust particles.

Pěnčíková K, Ciganek M, Neča J, Illés P, Dvořák Z, Vondráček J, Machala M.
The Science of the total environment. 2019 Aug;677()626-636.
Organic pollutants associated with diesel exhaust particles (DEP), such as polycyclic aromatic hydrocarbons (PAHs) and their derivatives, may negatively impact human health. However, a comprehensive overview of their effects on endocrine nuclear receptor activities is still missing. Here, we evaluat
PMID 31071665

Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.

Domingues M, Casaril AM, Birmann PT, Bampi SR, Lourenço DA, Vieira BM, Dapper LH, Lenardão EJ, Sonego M, Collares T, Seixas FK, Brüning CA, Savegnago L.
Behavioural brain research. 2019 Jul;366()96-107.
In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1,2-a] pyridine (MPI; 1, 10 or 50 mg/kg, i.g.) on
PMID 30877027

Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos.

Willi RA, Salgueiro-González N, Faltermann S, Hettich T, Fent K.
The Science of the total environment. 2019 Jul;672()183-191.
Many glucocorticoids occur in the aquatic environments but their adverse effects to fish are poorly known. Here we investigate effects of the natural glucocorticoid corticosterone and the synthetic glucocorticoids betamethasone and flumethasone in zebrafish embryos. Besides studying the effects of e
PMID 30954817

Japanese Journal

Clinical Importance of Drug-Drug Interaction Between Warfarin and Prednisolone and Its Potential Mechanism in Relation to the Niemann-Pick C1-Like 1-Mediated Pathway

Ito Sayo M,Yamanashi Yoshihide,Takada Tappei,Suzuki Hiroshi
日本循環器學誌 83(2), 471-480, 2019
… Background: Warfarin is an anticoagulant drug used to prevent thromboembolic disorders, but its pharmacological effect is affected by co-administered drugs. … Therefore, careful management of warfarin-related drug-drug interactions (DDIs) is necessary for its safety and effectiveness. …
NAID 130007556995

Characterization of the suppressive effects of extremely-low-frequency electric fields on a stress-induced increase in the plasma glucocorticoid level in mice.

Hori Takuya,Nedachi Takaki,Suzuki Hiroshi,Harakawa Shinji
Bioelectromagnetics 39(7), 516-528, 2018-10
… We recently suggested that an increase in the plasma glucocorticoid (GC) level in immobilized mice is suppressed by a 50-Hz electric field (EF) in an EF strength-dependent manner. … The present study aimed to assess the anti-stress effect of EFs in three scenarios: exposure to an EF of either 50 or 60 Hz, which are the standard power frequencies in most regions; … varying levels of environmental brightness during EF exposure; …
NAID 120006549616

Two-detector number and brightness analysis reveals spatio-temporal oligomerization of proteins in living cells

Fukushima Ryosuke,Yamamoto Johtaro,Ishikawa Hideto,Kinjo Masataka
Methods (140), 161-171, 2018-05-01
… Number and brightness analysis (N&B) is a useful tool for the simultaneous visualization of protein oligomers and their localization, with single-molecule sensitivity. … N&B determines particle brightness (fluorescence intensity per particle) and maps the spatial distribution of fluorescently labeled proteins by performing statistical analyses of the image series obtained using laser scanning microscopy. …
NAID 120006626573