WordNet

the quality of being specific rather than general; "add a desirable note of specificity to the discussion"; "the specificity of the symptoms of the disease"
the quality of being specific to a particular organism; "host specificity of a parasite"
a grammatical number category referring to two items or units as opposed to one item (singular) or more than two items (plural); "ancient Greek had the dual form but it has merged with the plural form in modern Greek"
any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphates

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Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.

Musumeci L1, Kuijpers MJ1, Gilio K1, Hego A1, Théâtre E1, Maurissen L1, Vandereyken M1, Diogo CV1, Lecut C1, Guilmain W1, Bobkova EV1, Eble JA1, Dahl R1, Drion P1, Rascon J1, Mostofi Y1, Yuan H1, Sergienko E1, Chung TD1, Thiry M1, Senis Y1, Moutschen M1, Mustelin T1, Lancellotti P1, Heemskerk JW1, Tautz L2, Oury C2, Rahmouni S2.
Circulation.Circulation.2015 Feb 17;131(7):656-68. doi: 10.1161/CIRCULATIONAHA.114.010186. Epub 2014 Dec 17.
BACKGROUND: A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. A better understanding of the molecular mechanisms leading to platelet activation is important for the development of improved therapies. Recently, protein tyrosine
PMID 25520375

Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity.

Pavic K1, Rios P, Dzeyk K, Koehler C, Lemke EA, Köhn M.
ACS chemical biology.ACS Chem Biol.2014 Jul 18;9(7):1451-9. doi: 10.1021/cb500240n. Epub 2014 May 9.
Vaccinia H1-related (VHR) phosphatase is a dual specificity phosphatase that is required for cell-cycle progression and plays a role in cell growth of certain cancers. Therefore, it represents a potential drug target. VHR is structurally and biochemically well characterized, yet its regulatory princ
PMID 24798147

Identification of four novel serum protein biomarkers in sepsis patients encoded by target genes of sepsis-related miRNAs.

Wang HJ, Wang BZ1, Zhang PJ2, Deng J, Zhao ZR3, Zhang X3, Xiao K3, Feng D4, Jia YH3, Liu YN3, Xie LX3.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jun;126(12):857-67. doi: 10.1042/CS20130301.
The goal of the present study was to identify novel protein biomarkers from the target genes of six serum miRNAs that we identified previously in patients with sepsis. The target genes were predicted by bioinformatics analysis; the levels of the respective proteins in the sera of patients with sepsi
PMID 24303815

Specialized Motor-Driven dusp1 Expression in the Song Systems of Multiple Lineages of Vocal Learning Birds

Horita Haruhito,Kobayashi Masahiko,Liu Wan-chun,Oka Kotaro,Jarvis Erich D.,Wada Kazuhiro
PLoS One 7(8), e42173, 2012-08-02
… We previously found that the neural activity-induced gene dual specificity phosphatase 1 (dusp1) was up-regulated in non-vocal circuits, specifically in sensory-input neurons of the thalamus and telencephalon; …
NAID 120004689044

平井剛
薬学雑誌. 乙号 132(1), 117-124, 2012
… As inhibitors for the dual-specificity protein phosphatase VHR, the neutral phosphate-mimicking core structure was designed based on natural product RK-682. …
NAID 130001871951

The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons

Horita Haruhito,Wada Kazuhiro,Rivas Miriam V.,Hara Erina,Jarvis Erich D.
The Journal of Comparative Neurology 518(14), 2873-2901, 2010-07-15
… Here, we report the first such gene, dual specificity phosphatase 1 (dusp1). …
NAID 120002317143