WordNet

the quality of being specific rather than general; "add a desirable note of specificity to the discussion"; "the specificity of the symptoms of the disease"
the quality of being specific to a particular organism; "host specificity of a parasite"
a grammatical number category referring to two items or units as opposed to one item (singular) or more than two items (plural); "ancient Greek had the dual form but it has merged with the plural form in modern Greek"
any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphates

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Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide.

Smallie T1, Ross EA1, Ammit AJ2, Cunliffe HE1, Tang T1, Rosner DR1, Ridley ML1, Buckley CD1, Saklatvala J3, Dean JL3, Clark AR4.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Jul 1;195(1):277-88. doi: 10.4049/jimmunol.1402830. Epub 2015 May 27.
Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wi
PMID 26019272

Production of DUSP1 protein using the baculovirus insect cell expression system and its in vitro effects on cancer cells.

Cheng P1, Zhu S1, Jun L1, Huang L1, Hong Y1.
International journal of molecular medicine.Int J Mol Med.2015 Jun;35(6):1715-9. doi: 10.3892/ijmm.2015.2179. Epub 2015 Apr 9.
The aim of the present study was to produce the human dual specificity phosphatase 1 (DUSP1) protein with biological activity and to investigate its in vitro effects on cancer cells. DUSP1 protein was expressed in the baculovirus expression system and purified by Ni-affinity chromatography followed
PMID 25872469

Disruption of a regulatory loop between DUSP1 and p53 contributes to hepatocellular carcinoma development and progression.

Hao PP1, Li H1, Lee MJ1, Wang YP1, Kim JH1, Yu GR1, Lee SY2, Leem SH3, Jang KY4, Kim DG5.
Journal of hepatology.J Hepatol.2015 Jun;62(6):1278-86. doi: 10.1016/j.jhep.2014.12.033. Epub 2015 Jan 21.
BACKGROUND & AIMS: Altered expression of dual specificity phosphatase 1 (DUSP1) is common in tumors including hepatocellular carcinoma (HCC), and is predictive of tumor progression and poor prognosis. However, the tumor suppressive role of DUSP1 has yet to be clearly elucidated.METHODS: The mole
PMID 25617504

Specialized Motor-Driven dusp1 Expression in the Song Systems of Multiple Lineages of Vocal Learning Birds

Horita Haruhito,Kobayashi Masahiko,Liu Wan-chun,Oka Kotaro,Jarvis Erich D.,Wada Kazuhiro
PLoS One 7(8), e42173, 2012-08-02
… We previously found that the neural activity-induced gene dual specificity phosphatase 1 (dusp1) was up-regulated in non-vocal circuits, specifically in sensory-input neurons of the thalamus and telencephalon; …
NAID 120004689044

平井剛
薬学雑誌. 乙号 132(1), 117-124, 2012
… As inhibitors for the dual-specificity protein phosphatase VHR, the neutral phosphate-mimicking core structure was designed based on natural product RK-682. …
NAID 130001871951

The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons

Horita Haruhito,Wada Kazuhiro,Rivas Miriam V.,Hara Erina,Jarvis Erich D.
The Journal of Comparative Neurology 518(14), 2873-2901, 2010-07-15
… Here, we report the first such gene, dual specificity phosphatase 1 (dusp1). …
NAID 120002317143