double minute

微小染色体

WordNet

1. used of flowers having more than the usual number of petals in crowded or overlapping arrangements; "double chrysanthemums have many rows of petals and are usually spherical or hemispherical"
2. increase twofold; "The population doubled within 50 years" (同)duplicate
3. a base hit on which the batter stops safely at second base; "he hit a double to deep centerfield" (同)two-base hit, two-bagger, two-baser
4. someone who closely resembles a famous person (especially an actor); "he could be Gingrichs double"; "shes the very image of her mother" (同)image, look-alike
5. a stand-in for movie stars to perform dangerous stunts; "his first job in Hollywood was as a double for Clark Gable" (同)stunt man, stunt woman
6. a quantity that is twice as great as another; "36 is the double of 18"
7. twice as great or many; "ate a double portion"; "the dose is doubled"; "a twofold increase" (同)doubled, twofold, two-fold
8. consisting of or involving two parts or components usually in pairs; "an egg with a double yolk"; "a double (binary) star"; "double doors"; "dual controls for pilot and copilot"; "duple (or double) time consists of two (or a multiple of two) beats to a measure" (同)dual, duple
9. having more than one decidedly dissimilar aspects or qualities; "a double (or dual) role for an actor"; "the office of a clergyman is twofold; public preaching and private influence"- R.W.Emerson; "every episode has its double and treble meaning"-Frederick Harrison (同)dual, twofold, two-fold, treble, threefold, three-fold
10. having two meanings with intent to deceive; "a sly double meaning"; "spoke with forked tongue" (同)forked
11. bridge: make a demand for (a card or suit)
12. do double duty; serve two purposes or have two functions; "She doubles as his wife and secretary"
13. downward and forward; "he was bent double with pain"
14. hit a two-base hit
15. large enough for two; "a double bed"; "a double room"
16. two together; "some people sleep better double"
17. characterized by painstaking care and detailed examination; "a minute inspection of the grounds"; "a narrow scrutiny"; "an exact and minute report" (同)narrow
18. a unit of angular distance equal to a 60th of a degree (同)arcminute, minute of arc
19. a unit of time equal to 60 seconds or 1/60th of an hour; "he ran a 4 minute mile" (同)min
20. a short note; "the secretary keeps the minutes of the meeting"
21. increase by a factor of two; "doubling with a computer took no time at all"
22. raising the stakes in a card game by a factor of 2; "I decided his double was a bluff" (同)double
23. badminton played with two players on each side
24. tennis played with two players on each side
25. a written account of what transpired at a meeting (同)proceedings, transactions

PrepTutorEJDIC

1. Deutsche mark
2. (数量・強さ・重さ・価値などが)『2倍の』,倍の / 『二重の』,二様の;複の,対の,2人用の / 表裏のある,二心ある / (意味が)二様にとれる,あいまいな / (花が)八重の,重弁の / 『2倍に』,2倍だけ(twice) / 二重に,二様に / 対をなして,二人いっしょに / 〈U〉『2倍』[の数量・価額など] / 〈C〉2倍のもの / 〈C〉よく似た人(物),生き写し / 〈C〉(映画の)代役 / 《複数形》《単数扱い》(テニスなどの)ダブルス / 〈C〉(獲物が追っ手を逃れるときなどの)逆走,急転回 / 〈C〉2塁打 / 〈C〉(ブリッジの点の)倍加 / 〈C〉(競馬・ドッグレースの)重勝式のかけ,複式 / …‘を'『2倍にする』 / …‘を'『二つ折りにする』 / …‘の'2倍の数(量)がある / 〈二役〉‘を'ひとりで演ずる / 〈船が〉〈岬〉‘を'回る / 『2倍になる』 / (…の役を)兼ねる《+『as』+『名』》 / (急に)取って返す,逆戻りする《+『back』》 / 二つ折りになる / (ブリッジで)相手のせり高を倍加する / 2塁打を打つ
3. (時間の単位の)『分』(1/60時間;《略》『m.,min.』) / (角度の単位の)分(1/60度;記号は'で,数字の後に付ける) / 〈U〉《しばしばa ~》《話》『瞬間』,ちょっとの間(moment) / (また『minute book』)《複数形で》(会議の)景事録
4. 『ごく小さい』,微細な / 『精密な』,詳しい / ささいな,取るに足りない

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/11 05:16:02」(JST)

wiki en

[Wiki en表示]

Double minutes are small fragments of extrachromosomal DNA, which have been observed in a large number of human tumors including breast, lung, ovary, colon, and most notably, neuroblastoma. They are a manifestation of gene amplification during the development of tumors, which give the cells selective advantages for growth and survival. They frequently harbor amplified oncogenes and genes involved in drug resistance. Double minutes, like actual chromosomes, are composed of chromatin and replicate in the nucleus of the cell during cell division. Unlike typical chromosomes, they are composed of circular fragments of DNA, up to only a few million base pairs in size and contain no centromere or telomere.

References

• Baskin, F; Rosenberg, RN; Dev, V (June 1981). "Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells". Proc Natl Acad Sci USA 78 (6): 3654–3658. doi:10.1073/pnas.78.6.3654. PMC 319629. PMID 6943568.  Free full-text.
• Barker PE (February 1982). "Double minutes in human tumor cells". Cancer genetics and cytogenetics 5 (1): 81–94. doi:10.1016/0165-4608(82)90043-7. PMID 6175392. 
• Masters, J; Keeley, B; Gay, H; Attardi, G (1982). "Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines". Mol Cell Biol 2 (5): 498–507. PMC 369819. PMID 7110138.  Free full-text.

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BBSにて、Double Quotation・Double Minuteに関する質問がありましたので、色々と試してみました。まず下図のように、SimpleTextで「あ“いう”えお」と入力したテキストを用意しました（“”はShift JIS8167・8168です）。

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Related Pictures

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★リンクテーブル★

リンク元	「DM」
関連記事	「minute」「double」「doubling」

「DM」

　　[★]

• 糖尿病 diabetes mellitus
• 二重微小染色体 double minute chromosome double minute=微小染色体 minute chromosome
• 皮膚筋炎 dermatomyositis
• 筋強直性ジストロフィー 筋緊張性ジストロフィ myotonic dystrophy MD dystrophia myotonica DM
• デジタルマンモグラフィ digital mammography

　

「minute」

　　[★]

発音記号が違う

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• n.

• 分。一瞬、瞬間。(the ～)現在、今。1分間に進む距離
• 覚え書き、控え。(文書の)簡単な草案。(pl.)議事録

• adj.

• 急ごしらえの

• vt.

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• adj.

• 微少な、微細な。詳細な、精密な、細心な。些細な、取るに足らぬ

　 　 　 　 　 　

「double」

　　[★]

• adj.

同

outlet right ventricle

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「doubling」

　　[★]

• n.

• 倍加

関

double