donor leukocyte infusion

• ドナー白血球輸注

WordNet

1. a solution obtained by steeping or soaking a substance (usually in water) (同)extract
2. the process of extracting certain active properties (as a drug from a plant) by steeping or soaking (usually in water)
3. (medicine) the passive introduction of a substance (a fluid or drug or electrolyte) into a vein or between tissues (as by gravitational force)
4. the act of infusing or introducing a certain modifying element or quality; "the teams continued success is attributable to a steady infusion of new talent"
5. person who makes a gift of property (同)giver, presenter, bestower, conferrer
6. (medicine) someone who gives blood or tissue or an organ to be used in another person (the host)
7. the head of an organized crime family (同)father
8. blood cells that engulf and digest bacteria and fungi; an important part of the bodys defense system (同)leucocyte, white_blood_cell, white_cell, white blood corpuscle, white_corpuscle, WBC

PrepTutorEJDIC

1. 〈U〉(…を…に)教え込むこと,(…の)鼓吹,注入《+『of』+『名』+『into』+『名』》 / 〈C〉水(湯)に浸してできたもの;振り出し汁
2. 寄付者,寄贈者 / (移植用の組織・器官の)提供者,献血者
3. 《Don》ドン(Sirに当たるスペイン語で男性の洗礼名の前につける) / 〈C〉スペイン貴族(紳士) / 〈C〉(オックスフォード・ケンブリッジ両大学の)学監,指導教授 / 〈C〉《英》大学教師
4. 〈衣服〉‘を'着る,〈帽子〉‘を'かぶる[do onの短縮形]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/27 07:12:30」(JST)

wiki en

[Wiki en表示]

Donor lymphocyte (or leukocyte) infusion (DLI) or buffy coat fusion is a form of adoptive immunotherapy used after hematopoietic stem cell transplantation.

History

Formerly, the only treatment option that offered relapsed bone marrow transplant patients hope of a cure was another bone marrow transplant. However, the risk of serious, life-threatening complications after a second BMT is great. One strategy of managing relapse, donor leukocyte infusion, might eliminate the need for a second BMT in some patients.

Procedure

Donor leukocyte infusion is the infusion in which lymphocytes from the original stem cell donor are infused, after the transplant, to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted. These donated white blood cells contain cells of the immune system that can recognize and destroy cancer cells.

The goal of this therapy is to induce a remission of the patient's cancer by a process called the graft-versus-tumor effect (GVT). The donor T-cells can attack and control the growth of residual cancer cells providing the GVT effect. It is hoped that the donor leukocyte infusion will cause GVT and lead to a remission of the patients cancer.

Patients might require standard chemotherapy, to reduce the amount of cancer cells they have prior to their donor lymphocyte infusion.

Complications

Complications of DLI include acute and chronic graft-versus-host disease and bone marrow aplasia, resulting in immunosuppression and susceptibility to opportunistic infections.

References

Further reading

• Thomas' Hematopoietic Cell Transplantation, ed. Blume KG, Forman SJ, Appelbaum FR. Blackwell Publishers, Cambridge, MA: 2004. ISBN 1-4051-1256-5.

UpToDate Contents

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• 1. 造血細胞移植後の再発の予防および治療のための免疫療法 immunotherapy for the prevention and treatment of relapse following hematopoietic cell transplantation
• 2. 再発性または難治性の急性骨髄性白血病の治療 treatment of relapsed or refractory acute myeloid leukemia
• 3. 鎌状赤血球症における造血細胞移植 hematopoietic cell transplantation in sickle cell disease
• 4. 慢性骨髄性白血病における造血細胞移植 hematopoietic cell transplantation in chronic myeloid leukemia
• 5. 多発性骨髄腫における同種造血細胞移植 allogeneic hematopoietic cell transplantation in multiple myeloma

English Journal

• Clinical trials for induction of renal allograft tolerance.

• Elias N1, Cosimi AB, Kawai T.
• Current opinion in organ transplantation.Curr Opin Organ Transplant.2015 Aug;20(4):406-411.
• PURPOSE OF REVIEW: This review summarizes the current state of clinical trials for tolerance induction of human leukocyte antigen-matched or mismatched renal allografts via peritransplant infusion of donor bone marrow-derived products. Recent efforts to apply infusion of expanded regulatory T-cell p
• PMID 26147679

• Salvage chemotherapy followed by granulocyte colony-stimulating factor-primed donor leukocyte infusion with graft-vs.-host disease control for minimal residual disease in acute leukemia/myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation: prognostic factors and clinical outcomes.

• Mo XD1, Zhang XH1, Xu LP1, Wang Y1, Yan CH1, Chen H1, Chen YH1, Han W1, Wang FR1, Wang JZ1, Liu KY1, Huang XJ1,2,3.
• European journal of haematology.Eur J Haematol.2015 May 23. doi: 10.1111/ejh.12591. [Epub ahead of print]
• This study investigated the prognostic factors and clinical outcomes of preemptive chemotherapy followed by granulocyte colony-stimulating factor-primed donor leukocyte infusion (Chemo-DLI) according to minimal residual disease (MRD) status in patients with acute leukemia and myelodysplastic syndrom
• PMID 26010204

• Combination of a Haploidentical Stem Cell Transplant With Umbilical Cord Blood for Cerebral X-Linked Adrenoleukodystrophy.

• Jiang H1, Jiang MY2, Liu S1, Cai YN2, Liang CL2, Liu L3.
• Pediatric neurology.Pediatr Neurol.2015 May 14. pii: S0887-8994(15)00227-1. doi: 10.1016/j.pediatrneurol.2015.05.002. [Epub ahead of print]
• BACKGROUND: Childhood cerebral X-linked adrenoleukodystrophy is a rapidly progressive neurodegenerative disorder that affects central nervous system myelin and the adrenal cortex. Hematopoietic stem cell transplantation is the best available curative therapy if performed during the early stages of d
• PMID 26088837

Japanese Journal

• The Effect of Donor Leukocyte Infusion on Refractory Pure Red Blood Cell Aplasia after Allogeneic Stem Cell Transplantation in a Patient with Myelodysplastic Syndrome Developing from Kostmann Syndrome

• EBIHARA Yasuhiro,MANABE Atsushi,TSURUTA Toshihisa,ISHIKAWA Kumiko,HASEGAWA Daisuke,OHTSUKA Yoshitoshi,KAWASAKI Hirohide,OGAMI Kazuo,WADA Yuka,KANDA Tadayasu,TSUJI Kohichiro
• International journal of hematology 86(5), 446-450, 2007-12-15
• NAID 10019533345

• Graft-versus-host disease and graft-versus-leukemia after donor leukocyte infusion

• PORTER D
• Semin Hematol. 43, 53-61, 2006
• NAID 30015171520

• A case of immune recovery vitritis induced by donor leukocyte infusion for the treatment of cytomegalovirus retinitis

• KAWAKAMI M
• Eur J Haematol. 75, 352-354, 2005
• NAID 30013482399

Related Links

• Donor Leukocyte Infusion

It is hoped that the donor leukocyte infusion will cause GVT and lead to a remission of your cancer. Your donor will be contacted to begin the collection process, which can be like the original bone marrow donation process. After ...

• Donor Leukocyte Infusion (DLI): Blood and Marrow Transplant ...

Patients who have received a blood and marrow transplant (BMT) from a related or unrelated donor could still experience a relapse of their underlying disease/cancer. A donor leukocyte infusion (DLI) is a possible strategy for ...

Related Pictures

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★リンクテーブル★

リンク元	「ドナー白血球輸注」
関連記事	「infusion」「donor」

「ドナー白血球輸注」

　　[★]

英

donor leukocyte infusion

「infusion」

　　[★]

• n.

• 注入。吹き込むこと。(香料の)侵出。(医)注入、点滴、(浸剤の)温浸。注入物。浸出液、浸剤。混和物

関

digest、digestion、drip、drip infusion、infuse、inject、injection、instill、intravenous infusion、transfuse、transfusion

　 　 　 　 　

「donor」

　　[★]

• n.

• ドナー、提供者、臓器提供者、供与者、(化学)供与体

関

organ donor、provider、tissue donor