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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/03 13:49:42」(JST)
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Dyphylline
|
| Systematic (IUPAC) name |
|
7-(2,3-dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
|
| Clinical data |
| Trade names |
Lufyllin |
| AHFS/Drugs.com |
Consumer Drug Information |
| MedlinePlus |
a682494 |
Pregnancy
category |
- US: C (Risk not ruled out)
|
| Legal status |
|
| Identifiers |
| CAS Registry Number |
479-18-5 Y |
| ATC code |
R03DA01 |
| PubChem |
CID: 3182 |
| IUPHAR/BPS |
7070 |
| DrugBank |
DB00651 Y |
| ChemSpider |
3070 Y |
| UNII |
263T0E9RR9 Y |
| KEGG |
D00691 Y |
| ChEBI |
CHEBI:4728 Y |
| ChEMBL |
CHEMBL1752 Y |
| Synonyms |
7-(2,3-dihydroxy-propyl)theophylline |
| Chemical data |
| Formula |
C10H14N4O4 |
| Molecular mass |
254.24 g/mol |
SMILES
-
O=C2N(c1ncn(c1C(=O)N2C)CC(O)CO)C
|
InChI
-
InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3 Y
-
Key:KSCFJBIXMNOVSH-UHFFFAOYSA-N Y
|
| Y (what is this?) (verify) |
Dyphylline (USAN) (trade names Dilor, Lufyllin), also known as diprophylline (INN), is a xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.[1][2]
See also
References
- ^ Schwabe U, Ukena D, Lohse MJ (September 1985). "Xanthine derivatives as antagonists at A1 and A2 adenosine receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 330 (3): 212–21. doi:10.1007/bf00572436. PMID 2997628.
- ^ Iancu L, Shneur A, Cohen H (1979). "Trials with xanthine derivatives in systemic treatment of psoriasis". Dermatologica 159 (1): 55–61. doi:10.1159/000250562. PMID 225216.
|
Stimulants (N06B)
|
|
| Adamantanes |
- Adaphenoxate
- Adapromine
- Amantadine
- Bromantane
- Chlodantane
- Gludantane
- Memantine
- Midantane
|
|
| Adenosine antagonists |
- 8-Chlorotheophylline
- 8-Cyclopentyltheophylline
- 8-Phenyltheophylline
- Aminophylline
- Caffeine
- CGS-15943
- Dimethazan
- Paraxanthine
- SCH-58261
- Theobromine
- Theophylline
|
|
| Alkylamines |
- Cyclopentamine
- Cypenamine
- Cyprodenate
- Heptaminol
- Isometheptene
- Methylhexaneamine
- Octodrine
- Propylhexedrine
- Tuaminoheptane
|
|
| Ampakines |
- CX-516
- CX-546
- CX-614
- CX-691
- CX-717
- IDRA-21
- LY-404,187
- LY-503,430
- Nooglutyl
- Org 26576
- PEPA
- S-18986
- Sunifiram
- Unifiram
|
|
| Arylcyclohexylamines |
- Benocyclidine
- Dieticyclidine
- Esketamine
- Eticyclidine
- Gacyclidine
- Ketamine
- Phencyclamine
- Phencyclidine
- Rolicyclidine
- Tenocyclidine
- Tiletamine
|
|
| Benzazepines |
- 6-Br-APB
- SKF-77434
- SKF-81297
- SKF-82958
|
|
| Cholinergics |
- A-84,543
- A-366,833
- ABT-202
- ABT-418
- AR-R17779
- Altinicline
- Anabasine
- Arecoline
- Bradanicline
- Cotinine
- Cytisine
- Dianicline
- Epibatidine
- Epiboxidine
- GTS-21
- Ispronicline
- Nicotine
- PHA-543,613
- PNU-120,596
- PNU-282,987
- Pozanicline
- Rivanicline
- Sazetidine A
- SIB-1553A
- SSR-180,711
- TC-1698
- TC-1827
- TC-2216
- Tebanicline
- UB-165
- Varenicline
- WAY-317,538
|
|
| Convulsants |
- Anatoxin-a
- Bicuculline
- DMCM
- Flurothyl
- Gabazine
- Pentetrazol
- Picrotoxin
- Strychnine
- Thujone
|
|
| Eugeroics |
- Adrafinil
- Armodafinil
- CRL-40,941
- Fluorenol
- JZ-IV-10
- Modafinil
|
|
| Oxazolines |
- 4-Methylaminorex
- Aminorex
- Clominorex
- Cyclazodone
- Fenozolone
- Fluminorex
- Pemoline
- Thozalinone
|
|
| Phenethylamines |
|
|
| Phenmetrazines |
- 3-Fluorophenmetrazine
- Fenbutrazate
- Fenmetramide
- G-130
- Manifaxine
- Morazone
- Morforex
- Oxaflozane
- PD-128,907
- Phendimetrazine
- Phenmetrazine
- 2-Phenyl-3,6-dimethylmorpholine
- Pseudophenmetrazine
- Radafaxine
|
|
| Piperazines |
- 2C-B-BZP
- BZP
- CM156
- DBL-583
- GBR-12783
- GBR-12935
- GBR-13069
- GBR-13098
- GBR-13119
- MeOPP
- MBZP
- Vanoxerine
|
|
| Piperidines |
- 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine
- 1-(3,4-Dichlorophenyl)-1-(piperidin-2-yl)butane
- 2-Benzylpiperidine
- 2-Methyl-3-phenylpiperidine
- 3,4-Dichloromethylphenidate
- 4-Benzylpiperidine
- 4-Methylmethylphenidate
- Desoxypipradrol
- Difemetorex
- Diphenylpyraline
- Ethylnaphthidate
- Ethylphenidate
- Methylnaphthidate
- Isopropylphenidate
- Methylphenidate (Dexmethylphenidate)
- N-Methyl-3β-propyl-4β-(4-chlorophenyl)piperidine
- Nocaine
- Phacetoperane
- Pipradrol
- Propylphenidate
- SCH-5472
|
|
| Pyrrolidines |
- 2-Diphenylmethylpyrrolidine
- α-PPP
- α-PBP
- α-PHP
- α-PVP
- α-PVT
- Diphenylprolinol
- MDPPP
- MDPBP
- MDPV
- MPBP
- MPHP
- MPPP
- MOPPP
- Naphyrone
- PEP
- Picilorex
- Prolintane
- Pyrovalerone
|
|
| Racetams |
- Oxiracetam
- Phenylpiracetam
|
|
| Tropanes |
- 3-CPMT
- 3'-Chloro-3a-(diphenylmethoxy)tropane
- 4-fluorotropacocaine
- 4'-Fluorococaine
- AHN-1055
- Altropane (IACFT)
- Brasofensine
- CFT (WIN 35,428)
- β-CIT (RTI-55)
- Cocaethylene
- Cocaine
- Dichloropane (RTI-111)
- Difluoropine
- FE-β-CPPIT
- FP-β-CPPIT
- Ioflupane (123I)
- Norcocaine
- PIT
- PTT
- RTI-31
- RTI-32
- RTI-51
- RTI-105
- RTI-112
- RTI-113
- RTI-117
- RTI-120
- RTI-121 (IPCIT)
- RTI-126
- RTI-150
- RTI-154
- RTI-171
- RTI-177
- RTI-183
- RTI-193
- RTI-194
- RTI-199
- RTI-202
- RTI-204
- RTI-229
- RTI-241
- RTI-336
- RTI-354
- RTI-371
- RTI-386
- Salicylmethylecgonine
- Tesofensine
- Troparil (β-CPT, WIN 35,065-2)
- Tropoxane
- WF-23
- WF-33
- WF-60
|
|
| Tryptamines |
- 4-HO-αMT
- 4-Methyl-αET
- 4-Methyl-αMT
- 5-Chloro-αMT
- 5-Fluoro-αMT
- 5-MeO-αET
- 5-MeO-αMT
- 5-MeO-DIPT
- 6-Fluoro-αMT
- 7-Methyl-αET
- αET
- αMT
|
|
| Others |
- 2-MDP
- 2-Phenylcyclohexylamine
- 3,3-Diphenylcyclobutanamine
- Amfonelic acid
- Amineptine
- Amiphenazole
- Atipamezole
- Atomoxetine
- Bemegride
- Benzydamine
- BTQ
- BTS 74,398
- Ciclazindol
- Clofenciclan
- Cropropamide
- Crotetamide
- D-161
- Diclofensine
- Dimethocaine
- Efaroxan
- Etamivan
- Fenisorex
- Fenpentadiol
- Gamfexine
- Gilutensin
- GSK1360707F
- GYKI-52895
- Hexacyclonate
- Idazoxan
- Indanorex
- Indatraline
- JNJ-7925476
- Lazabemide
- Leptacline
- Levopropylhexedrine
- Lomevactone
- LR-5182
- Mazindol
- Meclofenoxate
- Medifoxamine
- Mefexamide
- Methastyridone
- Methiopropamine
- N-Methyl-3-phenylnorbornan-2-amine
- Nefopam
- Nikethamide
- Nomifensine
- O-2172
- Oxaprotiline
- PNU-99,194
- Propylhexedrine
- PRC200-SS
- Rasagiline
- Rauwolscine
- Rubidium chloride
- Setazindol
- Tametraline
- Tandamine
- Thiopropamine
- Trazium
- UH-232
- Yohimbine
|
|
|
Drugs for obstructive airway diseases: asthma/COPD (R03)
|
|
| Adrenergics, inhalants |
| Short acting β2-agonists |
- Bitolterol
- Carbuterol
- Fenoterol
- Pirbuterol
- Procaterol
- Reproterol
- Rimiterol
- Salbutamol#/Levosalbutamol
- Terbutaline
- Tulobuterol
|
|
| Long acting β2-agonists (LABA) |
- Arformoterol
- Bambuterol
- Clenbuterol
- Formoterol
- Salmeterol
- Salmefamol
- Ultra LABA: Indacaterol, Olodaterol, Vilanterol
|
|
| other |
- Epinephrine#
- Hexoprenaline
- Isoprenaline (Isoproterenol)
- Orciprenaline (Metaproterenol)
|
|
|
| Glucocorticoids |
- Beclometasone#
- Betamethasone
- Budesonide
- Ciclesonide
- Flunisolide
- Fluticasone
- Mometasone
- Triamcinolone
|
|
Anticholinergics/
muscarinic antagonist |
- Aclidinium bromide
- Glycopyrronium bromide
- Ipratropium bromide#
- Oxitropium bromide
- Tiotropium bromide
- Umeclidinium bromide
|
|
| Mast cell stabilizers |
|
|
| Xanthines |
- Acefylline
- Ambuphylline
- Bamifylline
- Doxofylline
- Enprofylline
- Etamiphylline
- Proxyphylline
- Theobromine
- Theophylline/Aminophylline/Choline theophyllinate
|
|
| Eicosanoid inhibition |
| Leukotriene antagonists |
- Montelukast
- Pranlukast
- Zafirlukast
|
|
| Arachidonate 5-lipoxygenase inhibitors |
- Baicalein§
- Caffeic acid§
- Curcumin§
- Hyperforin§
- Meclofenamate sodium§
- St John's wort§
- Zileuton
|
|
| Thromboxane receptor antagonists |
|
|
| Non-xanthine PDE4 inhibitors |
|
|
|
| Others/unknown |
- Amlexanox
- Eprozinol
- Fenspiride
- Omalizumab
|
|
| Combination products |
- Aclidinium/formoterol
- Budesonide/formoterol
- Fluticasone furoate/vilanterol
- Fluticasone/salmeterol
- Indacaterol/glycopyrrolate
- Ipratropium bromide/salbutamol
- Mometasone/formoterol
- Umeclidinium bromide/vilanterol
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
Index of the respiratory system
|
|
| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Congenital
- Neoplasms and cancer
- Chest trauma
- Infection
- common cold
- pneumonia
- tuberculosis
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- nasal
- throat
- obstructive airway diseases
- cough and cold
- histaminergics
- pulmonary arterial hypertension
- other
- Surgery
|
|
|
|
Adenosinergics
|
|
Receptor
(ligands) |
|
AR
|
- Agonists: 2-(1-Hexynyl)-N-methyladenosine
- 2-Cl-IB-MECA
- 2'-MeCCPA
- 4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil
- 5'-N-ethylcarboxamidoadenosine
- Adenosine
- ADP
- AMP
- Apadenoson
- ATL-146e
- ATP
- BAY 60–6583
- Binodenoson
- Capadenoson
- CCPA
- CGS-21680
- CP-532,903
- Evodenoson
- GR 79236
- LUF-5835
- LUF-5845
- N6-Cyclopentyladenosine
- Neladenoson dalanate
- Regadenoson
- SDZ WAG 994
- Selodenoson
- Sonedenoson
- Tecadenoson
- UK-432,097
- Antagonists: 8-Chlorotheophylline
- 8-Phenyl-1,3-dipropylxanthine
- 8-Phenyltheophylline
- Acefylline
- Aminophylline
- ATL-444
- Bamifylline
- Cafedrine
- Caffeine
- Caffeine citrate
- Cartazolate
- CF-101
- CGS-15943
- Choline theophyllinate
- CPX
- CVT-6883
- Dimethazan
- DMPX
- DPCPX
- Dyphylline
- Enprofylline
- Etazolate
- Fenethylline
- IBMX
- Isovaleric acid
- Istradefylline
- KF-26777
- MRE3008F20
- MRS-1220
- MRS-1334
- MRS-1706
- MRS-1754
- MRS-3777
- Paraxanthine
- Pentoxifylline
- Preladenant
- Propentofylline
- Proxyphylline
- PSB-10
- PSB-11
- PSB 36
- PSB-603
- PSB-788
- PSB-1115
- Rolofylline
- SCH-442,416
- SCH-58261
- Theacrine
- Theobromine
- Theodrenaline
- Theophylline
- Tozadenant
- Tracazolate
- VUF-5574
- ZM-241,385
|
|
|
Transporter
(blockers) |
|
ENTs
|
- Barbiturates
- Benzodiazepines
- Cilostazol
- Dilazep
- Dipyridamole
- Ethanol
- Hexobendine
- NBMPR
- Pentoxifylline
- Propentofylline
|
|
|
PMAT
|
|
|
|
|
Phosphodiesterase inhibitors
|
|
| PDE1 |
- MMPX
- SCH-51866
- Vinpocetine
|
|
| PDE2 |
|
|
| PDE3 |
- Amrinone
- Anagrelide
- Bucladesine
- Cilostamide
- Cilostazol
- Enoximone
- KMUP-1
- Milrinone
- Quazinone
- RPL-554
- Siguazodan
- Trequinsin
- Vesnarinone
- Zardaverine
|
|
| PDE4 |
- Apremilast
- Arofylline
- Atizoram
- Cilomilast
- Denbutylline
- Drotaverine
- Etazolate
- Filaminast
- Glaucine
- HT-0712
- Ibudilast
- ICI-63197
- Irsogladine
- Luteolin
- Mesembrine
- Piclamilast
- Roflumilast
- Rolipram
- RPL-554
- YM-976
|
|
| PDE5 |
- Acetildenafil
- Aildenafil
- Avanafil
- Dipyridamole
- Icariin
- Homosildenafil
- Lodenafil
- Mirodenafil
- MY-5445
- Nitrosoprodenafil
- Sildenafil
- Sulfoaildenafil
- T-0156
- Tadalafil
- Udenafil
- Vardenafil
|
|
| PDE6 |
|
|
| PDE7 |
|
|
| PDE9 |
|
|
| PDE10 |
- Papaverine
- PF-2545920
- Tofisopam
|
|
| PDE11 |
BC11-38
|
|
| Nonselective |
- Caffeine
- Doxofylline
- IBMX
- Pentoxifylline
- Propentofylline
- Theophylline
|
|
English Journal
- Measuring induction times and crystal nucleation rates.
- Brandel C1, Ter Horst JH.
- Faraday discussions.Faraday Discuss.2015 Apr 13. [Epub ahead of print]
- A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of nucleation if the number of nuclei forme
- PMID 25865429
- Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding.
- Claeys B1, Vervaeck A1, Hillewaere XK2, Possemiers S3, Hansen L4, De Beer T4, Remon JP1, Vervaet C5.
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2015 Feb;90:44-52. doi: 10.1016/j.ejpb.2014.11.003. Epub 2014 Nov 15.
- This study evaluated thermoplastic polyurethanes (TPUR) as matrix excipients for the production of oral solid dosage forms via hot melt extrusion (HME) in combination with injection molding (IM). We demonstrated that TPURs enable the production of solid dispersions - crystalline API in a crystalline
- PMID 25448075
- Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers - a case study with diprophylline.
- Claeys B1, De Bruyn S1, Hansen L2, De Beer T2, Remon JP1, Vervaet C3.
- International journal of pharmaceutics.Int J Pharm.2014 Dec 30;477(1-2):244-50. doi: 10.1016/j.ijpharm.2014.10.046. Epub 2014 Oct 23.
- The influence of several dicarboxylic acids on the release characteristics of polyurethane tablets with a high drug load was investigated. Mixtures of diprophylline (Dyph) and thermoplastic polyurethane (TPUR) (ratio: 50/50, 65/35 and 75/25 wt.%) were hot-melt extruded and injection molded with the
- PMID 25445517
Japanese Journal
- ケタミン，フェンタニルを用いたIV-PCAの有用性：整形外科上肢手術後症例での検討
- 術後オピオイド鎮痛に伴うPONV(術後悪心・嘔吐)予防策の検討 : ジフェンヒドラミン・ジプロフィリン配合薬(トラベルミン^【○!R】注)の有用性
- 日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia 33(1), 70-74, 2013-01-06
- NAID 10031147871
- オピオイドによる難治性の嘔気とめまいに対してヒスタミンH1受容体拮抗薬とペロスピロンの併用が有効であった2症例
Related Links
- Diprophylline - Get up-to-date information on Diprophylline side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Diprophylline ... Tell your doctor if you are pregnant or plan to become pregnant. The ...
- ジプロフィリン(Diprophylline)の検索ならお薬検索QLife（キューライフ）。お医者さんが処方する処方薬と、薬局で買える市販薬(OTC)、の効果と副作用、写真、添付文書、保管方法等を掲載。商品名だけでなく一般名や剤形、色などからも ...
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