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- diprophylline
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/03 09:49:20」(JST)
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Dyphylline
|
| Systematic (IUPAC) name |
| 7-(2,3-dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione |
| Clinical data |
| Trade names |
Lufyllin |
| AHFS/Drugs.com |
Consumer Drug Information |
| MedlinePlus |
a682494 |
| Pregnancy cat. |
C (US) |
| Legal status |
℞-only (US) |
| Identifiers |
| CAS number |
479-18-5 Y |
| ATC code |
R03DA01 |
| PubChem |
CID 3182 |
| DrugBank |
DB00651 |
| ChemSpider |
3070 Y |
| UNII |
263T0E9RR9 Y |
| KEGG |
D00691 Y |
| ChEBI |
CHEBI:4728 Y |
| ChEMBL |
CHEMBL1752 Y |
| Synonyms |
7-(2,3-dihydroxy-propyl)theophylline |
| Chemical data |
| Formula |
C10H14N4O4 |
| Mol. mass |
254.24 g/mol |
SMILES
- O=C2N(c1ncn(c1C(=O)N2C)CC(O)CO)C
|
InChI
-
InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3 Y
Key:KSCFJBIXMNOVSH-UHFFFAOYSA-N Y
|
| Y (what is this?) (verify) |
Dyphylline (trade names Dilor, Lufyllin), also known as diprophylline, is a xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.[1][2]
See also
References
- ^ Schwabe U, Ukena D, Lohse MJ (September 1985). "Xanthine derivatives as antagonists at A1 and A2 adenosine receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 330 (3): 212–21. PMID 2997628.
- ^ Iancu L, Shneur A, Cohen H (1979). "Trials with xanthine derivatives in systemic treatment of psoriasis". Dermatologica 159 (1): 55–61. PMID 225216.
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Stimulants (N06B)
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| Adamantanes |
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|
|
| Adenosine antagonists |
- 8-Chlorotheophylline
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- 8-Phenyltheophylline
- Aminophylline
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|
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| Benzazepines |
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| Cholinergics |
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- WAY-317,538
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| Convulsants |
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| Eugeroics |
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| Oxazolines |
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| Phenethylamines |
|
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| Phenmetrazines |
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- G-130
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- PD-128,907
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|
|
| Piperazines |
- 2C-B-BZP
- BZP
- CM156
- DBL-583
- GBR-12783
- GBR-12935
- GBR-13069
- GBR-13098
- GBR-13119
- MeOPP
- MBZP
- Vanoxerine
|
|
| Piperidines |
- 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine
- 1-(3,4-Dichlorophenyl)-1-(piperidin-2-yl)butane
- 2-Benzylpiperidine
- 2-Methyl-3-phenylpiperidine
- 3,4-Dichloromethylphenidate
- 4-Benzylpiperidine
- 4-Methylmethylphenidate
- Desoxypipradrol
- Difemetorex
- Diphenylpyraline
- Ethylphenidate
- Methylnaphthidate
- Methylphenidate (Dexmethylphenidate)
- N-Methyl-3β-propyl-4β-(4-chlorophenyl)piperidine
- Nocaine
- Phacetoperane
- Pipradrol
- SCH-5472
|
|
| Pyrrolidines |
- 2-Diphenylmethylpyrrolidine
- a-PPP
- a-PBP
- a-PVP
- Diphenylprolinol
- MDPPP
- MDPBP
- MDPV
- MPBP
- MPHP
- MPPP
- MOPPP
- Naphyrone
- PEP
- Prolintane
- Pyrovalerone
|
|
| Tropanes |
- 3-CPMT
- 3'-Chloro-3a-(diphenylmethoxy)tropane
- 4-fluorotropacocaine
- 4'-Fluorococaine
- AHN-1055
- Altropane (IACFT)
- Brasofensine
- CFT (WIN 35,428)
- β-CIT (RTI-55)
- Cocaethylene
- Cocaine
- Dichloropane (RTI-111)
- Difluoropine
- FE-β-CPPIT
- FP-β-CPPIT
- Ioflupane (123I)
- Norcocaine
- PIT
- PTT
- RTI-31
- RTI-32
- RTI-51
- RTI-105
- RTI-112
- RTI-113
- RTI-117
- RTI-120
- RTI-121 (IPCIT)
- RTI-126
- RTI-150
- RTI-154
- RTI-171
- RTI-177
- RTI-183
- RTI-193
- RTI-194
- RTI-199
- RTI-202
- RTI-204
- RTI-229
- RTI-241
- RTI-336
- RTI-354
- RTI-371
- RTI-386
- Salicylmethylecgonine
- Tesofensine
- Troparil (β-CPT, WIN 35,065-2)
- Tropoxane
- WF-23
- WF-33
- WF-60
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| Racetams |
- Oxiracetam
- Phenylpiracetam
|
|
| Others |
- 2-MDP
- 2-Phenylcyclohexylamine
- 3,3-Diphenylcyclobutanamine
- Amfonelic acid
- Amineptine
- Amiphenazole
- Atipamezole
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- PNU-99,194
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- PRC200-SS
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- Rubidium chloride
- Setazindol
- Tametraline
- Tandamine
- Thiopropamine
- Trazium
- UH-232
- Yohimbine
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|
|
Drugs for obstructive airway diseases: asthma/COPD (R03)
|
|
| Adrenergics, inhalants |
| Short acting β2-agonists |
- Bitolterol
- Carbuterol
- Fenoterol
- Pirbuterol
- Procaterol
- Reproterol
- Rimiterol
- Salbutamol#/Levosalbutamol
- Terbutaline
- Tulobuterol
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|
| Long acting β2-agonists (LABA) |
- Arformoterol
- Bambuterol
- Clenbuterol
- Formoterol
- Salmeterol
- Ultra LABA: Indacaterol, Olodaterol, Vilanterol
|
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| other |
- Epinephrine#
- Hexoprenaline
- Isoprenaline (Isoproterenol)
- Orciprenaline (Metaproterenol)
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|
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| Glucocorticoids |
- Beclometasone#
- Betamethasone
- Budesonide
- Ciclesonide
- Flunisolide
- Fluticasone
- Mometasone
- Triamcinolone
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|
Anticholinergics/
muscarinic antagonist |
- Aclidinium bromide
- Glycopyrronium bromide
- Ipratropium bromide#
- Oxitropium bromide
- Tiotropium bromide
- Umeclidinium bromide
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|
| Mast cell stabilizers |
|
|
| Xanthines |
- Acefylline
- Ambuphylline
- Bamifylline
- Doxofylline
- Enprofylline
- Etamiphylline
- Proxyphylline
- Theobromine
- Theophylline/Aminophylline/Choline theophyllinate
|
|
| Eicosanoid inhibition |
| Leukotriene antagonists |
- Montelukast
- Pranlukast
- Zafirlukast
|
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| Lipoxygenase inhibitor |
|
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| Thromboxane receptor antagonists |
|
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| Non-xanthine PDE4 inhibitors |
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| Others/unknown |
- Amlexanox
- Eprozinol
- Fenspiride
- Omalizumab
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| Combination products |
- Budesonide/formoterol
- Fluticasone/salmeterol
- Ipratropium bromide/salbutamol
- Mometasone/formoterol
- Beclometasone/formoterol
- Fluticasone furoate/vilanterol
- Umeclidinium bromide/vilanterol
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
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anat (n, x, l, c)/phys/devp
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noco (c, p)/cong/tumr, sysi/epon, injr
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proc, drug (R1/2/3/5/6/7)
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|
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Adenosinergics
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Receptor
ligands |
|
Agonists
|
- 2-(1-Hexynyl)-N-methyladenosine
- 2-Cl-IB-MECA
- 2'-MeCCPA
- 5'-N-ethylcarboxamidoadenosine
- ATL-146e
- BAY 60–6583
- CCPA
- CGS-21680
- CP-532,903
- GR 79236
- LUF-5835
- LUF-5845
- N6-Cyclopentyladenosine
- Regadenoson
- SDZ WAG 994
- UK-432,097
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|
|
Antagonists
|
- 8-Phenyl-1,3-dipropylxanthine
- Acefylline
- Aminophylline
- Bamifylline
- Caffeine
- CGS-15943
- 8-Chlorotheophylline
- CPX
- CVT-6883
- Dimethazan
- DPCPX
- Fenethylline
- Istradefylline
- KF-26777
- MRE3008F20
- MRS-1220
- MRS-1334
- MRS-1706
- MRS-1754
- MRS-3777
- Paraxanthine
- Pentoxifylline
- Preladenant
- Propentofylline
- PSB-10
- PSB-11
- PSB 36
- PSB-603
- PSB-788
- PSB-1115
- Rolofylline
- SCH-442,416
- SCH-58261
- Theobromine
- Theophylline
- VUF-5574
- ZM-241,385
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|
|
Reuptake
inhibitors |
|
Plasmalemmal
|
|
ENT inhibitors
|
- Dilazep
- Dipyridamole
- Hexobendine
- Pentoxifylline
- Propentofylline
- Barbiturates
- Ethanol
- Benzodiazepines
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|
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Vesicular
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|
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Phosphodiesterase inhibitors
|
|
| PDE1 |
- MMPX
- SCH-51866
- Vinpocetine
|
|
| PDE2 |
|
|
| PDE3 |
- Amrinone
- Anagrelide
- Bucladesine
- Cilostamide
- Cilostazol
- Enoximone
- KMUP-1
- Milrinone
- Quazinone
- RPL-554
- Siguazodan
- Trequinsin
- Vesnarinone
- Zardaverine
|
|
| PDE4 |
- Arofylline
- Atizoram
- Cilomilast
- Denbutylline
- Drotaverine
- Etazolate
- Filaminast
- Glaucine
- HT-0712
- Ibudilast
- ICI-63197
- Irsogladine
- Luteolin
- Mesembrine
- Piclamilast
- Roflumilast
- Rolipram
- Ro20-1724
- RPL-554
- YM-976
|
|
| PDE5 |
- Acetildenafil
- Aildenafil
- Avanafil
- Dipyridamole
- Icariin
- Lodenafil
- Mirodenafil
- MY-5445
- Nitrosoprodenafil
- Sildenafil
- Sulfoaildenafil
- T-0156
- Tadalafil
- Udenafil
- Vardenafil
|
|
| PDE6 |
|
|
| PDE7 |
|
|
| PDE9 |
|
|
| PDE10 |
- Papaverine
- PF-2545920
- Tofisopam
|
|
| Nonselective |
- Caffeine
- Doxofylline
- IBMX
- Pentoxifylline
- Propentofylline
- Theophylline
|
|
English Journal
- The effect of polymer properties on direct compression and drug release from water-insoluble controlled release matrix tablets.
- Grund J1, Koerber M2, Walther M1, Bodmeier R1.
- International journal of pharmaceutics.Int J Pharm.2014 Jul 20;469(1):94-101. doi: 10.1016/j.ijpharm.2014.04.033. Epub 2014 Apr 16.
- The objective of this study was to identify and evaluate key polymer properties affecting direct compression and drug release from water-insoluble matrices. Commonly used polymers, such as Kollidon(®) SR, Eudragit(®) RS and ethyl cellulose, were characterized, formulated into tablets and compared
- PMID 24746409
- Mechanisms of diphylline release from dual-solute loaded poly(vinyl alcohol) matrices.
- Hasimi A1, Papadokostaki KG, Sanopoulou M.
- Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2014 Jan 1;34:369-76. doi: 10.1016/j.msec.2013.09.027. Epub 2013 Sep 29.
- The release kinetics of the model hydrophilic drug, diphylline (DPL), from physically crosslinked poly(vinyl alcohol) (PVA) matrices, is studied in relation to the drug load and the presence of a second solute incorporated in the matrix. The second solute, a gadolinium (III) complex (Gd-DTPA), is a
- PMID 24268271
- Maculopapular-type drug eruption caused by Coughcode(®)-N combination tablets.
- Yokose C1, Nakai N, Katoh N.
- Allergology international : official journal of the Japanese Society of Allergology.Allergol Int.2013 Dec;62(4):519-21. doi: 10.2332/allergolint.13-LE-0558. Epub 2013 Sep 25.
- PMID 24060762
Japanese Journal
- Utilization of intravenous dihydroxypro-pyltheophylline (dyphylline) in an aminophlline-sensitive patient, and its pharmacokinetic comparison with theophylline
Related Links
- Easy to read patient leaflet for dyphylline. Includes indications, proper use, special instructions, precautions, and possible side effects. ... Disclaimer: This information should not be used to decide whether or not to take this medicine ...
- Find patient medical information for dyphylline oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... This medication is used to treat and prevent wheezing and trouble ...
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