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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/28 03:25:48」(JST)

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Diflorasone is a topical steroid that comes in the form of a cream containing diflorasone diacetate. In is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis^[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class III steroid (of classes I–IV).^[2]

No long-term animal studies have been done to determine whether diflorasone could have carcinogenic properties.

Little data is available regarding whether diflorasone would be present in great enough quantities to cause harm to an infant.^[2]

References

^ Shupack, J. L.; Jondreau, L.; Kenny, C.; Stiller, M. J. (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology (Basel, Switzerland) 186 (2): 129–132. PMID 8428041. edit
^ ^a ^b Drugs.com: Diflorasone topical

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1. 扁平苔癬 lichen planus

English Journal

Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.

Schaper K1, Dickhaut J, Japtok L, Kietzmann M, Mischke R, Kleuser B, Bäumer W.
Journal of dermatological science.J Dermatol Sci.2013 Jul;71(1):29-36. doi: 10.1016/j.jdermsci.2013.03.006. Epub 2013 Apr 6.
BACKGROUND: It has been indicated that the sphingolipid sphingosine-1-phosphate (S1P) restrains the ability of dendritic cells to migrate to lymph nodes. Furthermore S1P has been demonstrated to inhibit cell growth in human keratinocytes. However, only little is known about the effect of S1P in hype
PMID 23643308

Structures from powders: diflorasone diacetate.

Maccaroni E1, Giovenzana GB, Palmisano G, Botta D, Volante P, Masciocchi N.
Steroids.Steroids.2009 Jan;74(1):102-11. doi: 10.1016/j.steroids.2008.09.014. Epub 2008 Oct 18.
Diflorasone diacetate, a steroid anti-inflammatory drug (marketed as Diacort or Florone by Pfizer) and used in the treatment of skin disorders, can be prepared as anhydrous form, DD1 (as deposited in the US pharmacopoeia), or as a monohydrated phase, DDW. Heating the DDW form above 90 degrees C, a m
PMID 19013475

Non-steroidal and steroidal anti-inflammatory drugs vary in their modulation of dendritic cell function in the elicitation phase of allergic contact dermatitis.

Bäumer W1, Krekeler S, DeVries VC, Niedorf F, Tschernig T, Kietzmann M.
Experimental dermatology.Exp Dermatol.2006 Apr;15(4):322-9.
The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation pha
PMID 16512880

Japanese Journal

ほう疹状膿か疹様外観を呈した妊婦自家感作性皮膚炎の１例

谷守,佐野栄紀,堤真理
皮膚の科学 4(3), 240-243, 2005
35歳女性。妊娠35週。2004年9月4日初診。初診の3週間前より下肢にそう痒性の紅斑および漿液性丘疹が出現し，掻破するうち数を増し体幹にも拡大してきた。自家感作性皮膚炎の診断のもとにプロピオン酸ベクロメタゾン軟膏(プロパデルム<SUP>®</SUP>)を外用したがさらに皮疹範囲が拡大した。同年10月に外用を酢酸ジフロラゾン軟膏(ダイアコート<SUP>®< …
NAID 130004934386

多剤ステロイド接触皮膚炎

宮下正人,多田讓治,荒川謙三,荒田次郎,原本美千恵
西日本皮膚科 52(4), 701-706, 1990
48歳男子。約10年前, 左前腕熱傷のため種々の外用治療を受けるも治癒が遷延し, 外用剤に対する過敏性が示唆されたことがあつた。今回, 湿疹病変に対し種々のステロイド外用剤を使用したが軽快傾向を示さず, コルチコステロイド主剤および外用剤基剤に対する過敏性が疑われたため, 種々の主剤および基剤のパッチテストを施行した結果, 吉草酸ジフルコルトロン, ベタメサゾン, 吉草酸ベタメサゾン, ジ酢酸ジフ …
NAID 130004473574

ダイアコート軟膏の臨床効果と安全性についての検討　　尋常性乾せん，苔せん型湿疹・皮膚炎を対象としたネリゾナ軟膏との比較試験:尋常性乾癬, 苔癬型湿疹・皮膚炎を対象としたネリゾナ軟膏との比較試験

上村寛行,朝田康夫
皮膚 30(4), 558-565, 1988
… Diflorasone diacetate 軟膏 (ダイアコート軟膏以下DDA軟膏) およびdiflucortolone 21-valerate軟膏 (ネリゾナ軟膏以下DFV軟膏) を用い, 尋常性乾癬8例, 苔癬化型湿疹・皮膚炎6例および痒疹1例に対する臨床効果と副作用について比較検討した。 …
NAID 130004045175

「ジフロラゾン」

Diflorasone
Systematic (IUPAC) name
	[17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
Clinical data
Trade names	Psorcon
AHFS/Drugs.com	monograph
MedlinePlus	a602019
Pregnancy cat.	US: C;
Legal status	US: ℞-only;
Routes	Topical
Identifiers
CAS number	1-13-8
ATC code	D07AC10
PubChem	CID 71414
DrugBank	DB00223
ChemSpider	64504
UNII	T2DHJ9645W
KEGG	D01327
ChEBI	CHEBI:31483
ChEMBL	CHEMBL1201380
Chemical data
Formula	C26H32F2O7
Mol. mass	494.525 g/mol
	InChI InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 ; Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-N ;
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