ジフロラゾン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/29 20:36:20」(JST)
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Diflorasone
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| Systematic (IUPAC) name |
|
[17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
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| Clinical data |
| Trade names |
Psorcon |
| AHFS/Drugs.com |
monograph |
| MedlinePlus |
a602019 |
Pregnancy
category |
- US: C (Risk not ruled out)
|
| Legal status |
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Routes of
administration |
Topical |
| Identifiers |
| CAS Registry Number |
1-13-8 N |
| ATC code |
D07AC10 |
| PubChem |
CID: 71414 |
| IUPHAR/BPS |
7068 |
| DrugBank |
DB00223 Y |
| ChemSpider |
64504 Y |
| UNII |
T2DHJ9645W Y |
| KEGG |
D01327 Y |
| ChEBI |
CHEBI:31483 Y |
| ChEMBL |
CHEMBL1201380 N |
| Chemical data |
| Formula |
C26H32F2O7 |
| Molecular mass |
494.525 g/mol |
InChI
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InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 Y
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Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-N Y
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| N (what is this?) (verify) |
Diflorasone is a topical steroid that comes in the form of a cream containing diflorasone diacetate. In is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class III steroid (of classes I–IV).[2]
No long-term animal studies have been done to determine whether diflorasone could have carcinogenic properties.[citation needed]
Little data is available regarding whether diflorasone would be present in great enough quantities to cause harm to an infant.[2]
References
- ^ Shupack, J. L.; Jondreau, L.; Kenny, C.; Stiller, M. J. (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology (Basel, Switzerland) 186 (2): 129–132. PMID 8428041. edit
- ^ a b Drugs.com: Diflorasone topical
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Glucocorticoids and antiglucocorticoids (H02)
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| Agonists |
| Pregnene |
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| Pregnenedione |
- Hydrocortisone (cortisol)# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- HALOGENATED AT 6: Cloprednol
- HALOGENATED, WITH FG AT 16: Halcinonide
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|
| Pregnadiene |
- Rimexolone
- HALOGENATED, WITH FG AT 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
|
|
| Pregnadienediol |
- Prednisone (Meprednisone)
- HALOGENATED AT 9: Fluorometholone
- HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
|
|
| Pregnadienetriol |
- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- HALOGENATED: Fluprednisolone (Difluprednate
- Fluperolone)
- HALOGENATED, WITH FG AT 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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| Pregnatriene |
|
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| Androstene |
- HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
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| Others/unsorted |
- HALOGENATED: Loteprednol
- HALOGENATED, WITH FG AT 16: Fludroxycortide
- Formocortal
- Mometasone furoate
- Promestriene
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|
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Antagonists /
SGRMs |
- Antagonists: Mifepristone
|
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| Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
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-
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of hormones
|
|
| Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
|
|
| Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
|
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| Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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Glucocorticoidics
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Receptor
(ligands) |
|
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Enzyme
(modulators) |
- See here instead (modulators of 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase).
|
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| Others |
- Precursors/prohormones: Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- 11-Deoxycorticosterone
- Indirect: ACTH (corticotropin)
- CRH
- DHEA
- DHEA sulfate
- Plasma proteins (albumin, transcortin)
- Vasopressin
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See also: Androgenics • Estrogenics • Mineralocorticoidics • Progestogenics
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UpToDate Contents
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English Journal
- Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.
- Schaper K1, Dickhaut J, Japtok L, Kietzmann M, Mischke R, Kleuser B, Bäumer W.
- Journal of dermatological science.J Dermatol Sci.2013 Jul;71(1):29-36. doi: 10.1016/j.jdermsci.2013.03.006. Epub 2013 Apr 6.
- BACKGROUND: It has been indicated that the sphingolipid sphingosine-1-phosphate (S1P) restrains the ability of dendritic cells to migrate to lymph nodes. Furthermore S1P has been demonstrated to inhibit cell growth in human keratinocytes. However, only little is known about the effect of S1P in hype
- PMID 23643308
- Structures from powders: diflorasone diacetate.
- Maccaroni E1, Giovenzana GB, Palmisano G, Botta D, Volante P, Masciocchi N.
- Steroids.Steroids.2009 Jan;74(1):102-11. doi: 10.1016/j.steroids.2008.09.014. Epub 2008 Oct 18.
- Diflorasone diacetate, a steroid anti-inflammatory drug (marketed as Diacort or Florone by Pfizer) and used in the treatment of skin disorders, can be prepared as anhydrous form, DD1 (as deposited in the US pharmacopoeia), or as a monohydrated phase, DDW. Heating the DDW form above 90 degrees C, a m
- PMID 19013475
- Non-steroidal and steroidal anti-inflammatory drugs vary in their modulation of dendritic cell function in the elicitation phase of allergic contact dermatitis.
- Bäumer W1, Krekeler S, DeVries VC, Niedorf F, Tschernig T, Kietzmann M.
- Experimental dermatology.Exp Dermatol.2006 Apr;15(4):322-9.
- The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation pha
- PMID 16512880
Japanese Journal
- ほう疹状膿か疹様外観を呈した妊婦自家感作性皮膚炎の１例
- ダイアコート軟膏の臨床効果と安全性についての検討 尋常性乾せん，苔せん型湿疹・皮膚炎を対象としたネリゾナ軟膏との比較試験:尋常性乾癬, 苔癬型湿疹・皮膚炎を対象としたネリゾナ軟膏との比較試験
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