WordNet

spread out; not concentrated in one place; "a large diffuse organization"
move outward; "The soldiers fanned out" (同)spread, spread out, fan out
lacking conciseness; "a diffuse historical novel"
relating to or existing on or affecting the skin; "cutaneous nerves"; "a cutaneous infection" (同)cutaneal, dermal
any pathological hardening or thickening of tissue (同)induration
(of light rays) subjected to scattering by reflection from a rough surface or transmission through a translucent material; "diffused light"
spreading by diffusion (同)diffusive, dispersive, disseminative

PrepTutorEJDIC

〈光・熱・液体など〉‘を'散らす,放散する,拡散させる / 〈学問・知識など〉‘を'広める,普及させる / 散る,放散する,拡散する / 広まる,普及する / 広く散った,広がった / 〈文体などが〉締まりのない,散漫な
皮膚の,皮膚を冒す
(組織・血管などの)硬化,硬化症

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 成人における全身性硬化症（強皮症）の治療および予後の概要 overview of the treatment and prognosis of systemic sclerosis scleroderma in adults
2. 成人における全身性硬化症（強皮症）の臨床症状の概要 overview of the clinical manifestations of systemic sclerosis scleroderma in adults
3. 全身性硬化症（強皮症）における肺合併症の概要 overview of pulmonary complications of systemic sclerosis scleroderma
4. 強皮症の概要および分類 overview and classification of scleroderma disorders
5. 若年性全身性硬化症（強皮症） juvenile systemic sclerosis scleroderma

Incidence and predictors of cutaneous manifestations during the early course of systemic sclerosis: a 10-year longitudinal study from the EUSTAR database.

Wirz EG1, Jaeger VK2, Allanore Y3, Riemekasten G4, Hachulla E5, Distler O6, Airò P7, Carreira PE8, Tikly M9, Vettori S10, Balbir Gurman A11, Damjanov N12, Müller-Ladner U13, Distler J14, Li M15, Häusermann P16, Walker UA2; EUSTAR coauthors.
Annals of the rheumatic diseases.Ann Rheum Dis.2016 Jul;75(7):1285-92. doi: 10.1136/annrheumdis-2015-207271. Epub 2015 Jul 31.
OBJECTIVES: To longitudinally map the onset and identify risk factors for skin sclerosis and digital ulcers (DUs) in patients with systemic sclerosis (SSc) from an early time point after the onset of Raynaud's phenomenon (RP) in the European Scleroderma Trials and Research (EUSTAR) cohort.METHODS: 6
PMID 26232495

Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis.

Cipriani P1, Di Benedetto P1, Ruscitti P1, Liakouli V1, Berardicurti O1, Carubbi F1, Ciccia F1, Guggino G1, Zazzeroni F1, Alesse E1, Triolo G1, Giacomelli R1.
The Journal of rheumatology.J Rheumatol.2016 Jul;43(7):1340-9. doi: 10.3899/jrheum.150996. Epub 2016 Jun 1.
OBJECTIVE: Microvascular damage is pivotal in the pathogenesis of systemic sclerosis (SSc), preceding fibrosis, and whose trigger is not still fully understood. Perivascular progenitor cells, with profibrotic activity and function, are identified by the expression of the isoform 12 of ADAM (ADAM12)
PMID 27252423

Turk M1, Pope JE2.
The Journal of rheumatology.J Rheumatol.2016 Jul;43(7):1350-5. doi: 10.3899/jrheum.151353. Epub 2016 May 1.
OBJECTIVE: Systemic sclerosis (SSc) leads to a high mortality from internal organ involvement. Scleroderma renal crisis (SRC) usually occurs in the diffuse cutaneous SSc (dcSSc) subset early in the disease, often with acute severe hypertension and renal failure. Prevalence of SRC since its classific
PMID 27134252

Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis

Makino Katsunari,Jinnin Masatoshi,Makino Takamitsu,Kajihara Ikko,Fukushima Satoshi,Inoue Yuji,Ihn Hironobu
BioScience Trends 8(3), 144-148, 2014
… Hypoxia may play an important role in the pathogenesis of systemic sclerosis (SSc). … SSD patients had significantly lower CA IX levels than diffuse cutaneous SSc (dcSSc), limited cuntaneous SSc (lcSSc) and healthy control groups. …
NAID 130004572597

A Patient with Diffuse Cutaneous Systemic Sclerosis Complicated by Antineutrophil-cytoplasmic Antibody-associated Vasculitis Exhibiting Honeycomb Lung without Volume Loss

Yamashita Hiroyuki,Takahashi Yuko,Kaneko Hiroshi,Kano Toshikazu,Mimori Akio
Internal Medicine 53(7), 801-804, 2014
… We herein report the case of a 72-year-old woman with diffuse cutaneous systemic sclerosis (SSc) complicated by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis who exhibited honeycomb lung without volume loss. … A renal biopsy revealed global sclerosis and cellular crescent formation. …
NAID 130003392746

A portable dermatoscope for easy, rapid examination of periungual nailfold capillary changes in patients with systemic sclerosis.

Muroi Eiji,Hara Toshihide,Yanaba Koichi,Ogawa Fumihide,Yoshizaki Ayumi,Takenaka Motoi,Shimizu Kazuhiro,Sato Shinichi
Rheumatology international 31(12), 1601-1606, 2011-12
… Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. … Twenty-one patients (16 women, 5 men) had diffuse cutaneous SSc and 62 (52 women, 10 men) had limited cutaneous SSc. …
NAID 120002223828