WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
the 4th letter of the Roman alphabet (同)d
informal term for information; "give me the gen on your new line of computers"

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1. マントル細胞リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of mantle cell lymphoma
2. 脾辺縁帯リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of splenic marginal zone lymphoma
3. 原発性副甲状腺機能亢進症の発症機序および病因 pathogenesis and etiology of primary hyperparathyroidism
4. B細胞前リンパ球性白血病 b cell prolymphocytic leukemia
5. 血液悪性腫瘍およびリンパ悪性腫瘍の遺伝的異常 genetic abnormalities in hematologic and lymphoid malignancies

Construction of the tissue engineering seed cell (HaCaT-EGF) and analysis of its biological characteristics.

Tao K, Bai XZ, Zhang ZF, Shi JH, Hu XL, Tang CW, Hu DH, Han JT.SourceBurn Center of PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, P.R. China.
Asian Pacific journal of tropical medicine.Asian Pac J Trop Med.2013 Nov;6(11):893-896. doi: 10.1016/S1995-7645(13)60159-5.
OBJECTIVE: To construct the tissue engineering seed cell (HaCaT cell line) with stable expression of the human epidermal growth factor (EGF), and analyze the changes of its biological characteristics.METHODS: PCDNA3.1-EGF eukaryotic expression vector was transferred into HaCaT cell, and G418 was uti
PMID 24083586

Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing.

Pyo CW, Choi JH, Oh SM, Choi SY.SourceDepartment of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Nov;1830(11):5316-25. doi: 10.1016/j.bbagen.2013.07.030. Epub 2013 Aug 3.
BACKGROUND: Cyclin D1 is immediately down-regulated in response to reactive oxygen species (ROS) and implicated in the induction of cell cycle arrest in G2 phase by an unknown mechanism. Either treatment with a protease inhibitor alone or expression of protease-resistant cyclin D1 T286A resulted in
PMID 23920145

Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation.

Piplani H, Rana C, Vaish V, Vaiphei K, Sanyal SN.SourceDepartment of Biophysics, Panjab University, Chandigarh 160014, India.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Nov;1830(11):5142-56. doi: 10.1016/j.bbagen.2013.07.011. Epub 2013 Jul 18.
BACKGROUND: Phosphoinositide 3-kinase (PI3-K) is an important regulator of oncogenesis and apoptosis in various types of cancers including colon cancer. A combinatorial strategy of using Cyclooxygenase-2 inhibitor, Celecoxib and Dolastatin, a linear peptide from marine mollusks of Indian Ocean origi
PMID 23872169

Molecular Targeting Therapy Against Promyelocytic Leukemia Protein Using Arsenic Acids in Experimental Intracranial Medulloblastoma

GU Chunyu,YOKOTA Naoki,GAO Yun,AMANO Shinji,KOIZUMI Shinichiro,TOKUYAMA Tsutomu,NAMBA Hiroki
Neurologia medico-chirurgica = 神経外科 52(2), 62-67, 2012-02-15
… Our previous study using human Daoy medulloblastoma cells showed that the promyelocytic leukemia (PML) gene was significantly upregulated (2.5-fold) in cells positive to prominin-1 antigen (CD133), a possible marker for cancer initiating cells. … PML and CCND1 (cyclin D1) protein expression of Daoy medulloblastoma cells was downregulated by As2O3 treatment. …
NAID 10030127244

Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling

Kitajima Shunsuke,Miki T.,Takegami Yujiro,Kido Y.,Noda M.,Hara Eiji,Shamma Awad,Takahashi Chiaki
Oncogene 30(6), 737-750, 2011-02-10
… The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene had been isolated as an antagonist to RAS signaling; … Within 2 days of RECK depletion, we observed a transient increase in protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) phosphorylation associated with an upregulated expression of cyclin D1, p19Arf, Trp53, p21Cdkn1a and Sprouty 2. …
NAID 120002907445