WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
lying between two extremes in time or space or state; "going from sitting to standing without intermediate pushes with the hands"; "intermediate stages in a process"; "intermediate stops on the route"; "an intermediate range plane"
a substance formed during a chemical process before the desired product is obtained
(botany) a part into which a leaf is divided
a rounded projection that is part of a larger structure
(anatomy) a somewhat rounded subdivision of a bodily organ or part; "ear lobe"
the enhanced response of an antenna in a given direction as indicated by a loop in its radiation pattern
propel in a high arc; "lob the tennis ball"
an easy return of a tennis ball in a high arc
the act of propelling something (as a ball or shell etc.) in a high arc
having deeply indented margins but with lobes not entirely separate from each other (同)lobate

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
(程度・距離・時間などにおいて)中間の,中間にある(起こる)
耳たぶ / (内臓・組織の)葉(よう)(肺葉・肝葉など)
(テニスで)〈ボール〉‘を'ゆるく高く打ち上げる / (クリケットで)〈ボール〉‘を'下手投げでゆるく投げる / (テニスで)ボールをロブで返す / (テニスの)ロブで打った球 / (クリケットの)下手投げの緩い球
(葉が)裂片がある / (体の器官に)葉(よう：lobe)がある / 耳たぶのついた;葉(よう)のある

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/16 00:23:21」(JST)

wiki en

Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally-occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),^[1]^[2] which in turn is a cleavage product of proopiomelanocortin (POMC).^[3] Although it does not appear to play any particularly important roles in the body,^[4] it does have some biological activity,^[5]^[6] especially of the neurological variety.^[7]^[8]^[9]^[10]^[11]

References[edit]

^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry 254 (23): 11903–6. PMID 227883.
^ Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. p. 78. ISBN 978-0-8493-8852-1. Retrieved 25 November 2011.
^ Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. p. 12. ISBN 978-0-12-521441-4. Retrieved 25 November 2011.
^ Larry Rex Engelking (1 June 2002). Review of veterinary physiology. Teton NewMedia. p. 411. ISBN 978-1-893441-69-9. Retrieved 25 November 2011.
^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation 74 (5): 1886–9. doi:10.1172/JCI111608 . PMC 425369. PMID 6209301.
^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O . PMID 1849784.
^ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. p. 136. ISBN 978-0-8493-4822-8. Retrieved 25 November 2011.
^ Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides 15 (2): 61–74. PMID 1981927.
^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides 15 (2): 75–88. PMID 1964203.
^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine 147 (3): 319–22. PMID 19529852.
^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K . PMID 8134304.

External links[edit]

Corticotropin-Like Intermediate Lobe Peptide at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. コルチコトロピン-放出ホルモン（CRH）の生理学 physiology of corticotropin releasing hormone
2. 膵ポリペプチド、ペプチドYY、およびニューロペプチドY pancreatic polypeptide peptide yy and neuropeptide y
3. コルチコトロピン-放出ホルモン（CRH）刺激試験 corticotropin releasing hormone stimulation test
4. 胎盤の発達および生理学 placental development and physiology
5. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure

English Journal

Expression patterns of c-Fos early gene and phosphorylated ERK in the rat brain following 1-h immobilization stress: concomitant changes induced in association with stress-related sleep rebound.

Keshavarzy F1, Bonnet C, Behzadi G, Cespuglio R.
Brain structure & function.Brain Struct Funct.2015;220(3):1793-804. doi: 10.1007/s00429-014-0728-6. Epub 2014 Feb 25.
An immobilization stress (IS) of 1 h applied at the beginning of the dark phase is followed by a sleep rebound. During the restraint, serotonin released by the dorsal raphe nucleus within the arcuate area stimulates the availability of corticotropin-like intermediate lobe peptide (CLIP or ACTH18-39)
PMID 24567082

The multiplicity of post-translational modifications in pro-opiomelanocortin-derived peptides.

Yasuda A1, Jones LS2, Shigeri Y1.
Frontiers in endocrinology.Front Endocrinol (Lausanne).2013 Dec 2;4:186. doi: 10.3389/fendo.2013.00186.
The precursor protein, pro-opiomelanocortin (POMC) undergoes extensive post-translational processing in a tissue-specific manner to yield various biologically active peptides involved in diverse cellular functions. The recently developed method of matrix-assisted laser desorption/ionization mass spe
PMID 24348461

Effect of somatostatin on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in the neurons of rat brain.

Grigoriev VV1, Petrova LN, Gabrelian AV, Zamoyski VL, Serkova TP, Bachurin SO.
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2012 Nov;154(1):10-2.
We studied the effect of somatostatin on presinaptic NMDA receptors and postsinaptic GABA, NMDA, and AMPA receptors in rat brain. It was shown that somatostatin inhibits NMDA-induced (45)Ca(2+) uptake into synaptosomes isolated from rat brain cortex (IC50=2.8×10(-11) M). Somatostatin potentiates AM
PMID 23330078

Japanese Journal

Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain

Brain Res Bull 26, 99-111, 1991
NAID 30008790967

Synthesis of the Docosapeptide corresponding to the Amino Acid Sequence of Salmon Corticotropin-like Intermediate Lobe Peptide (CLIP)

Chemical & pharmaceutical bulletin 30(11), 3970-3976, 1982-11-25
NAID 110003634185

Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Ostrich Adrenocorticotropic Hormone

Chemical & pharmaceutical bulletin 30(3), 866-873, 1982-03-25
NAID 110003634362

「メラニン細胞刺激ホルモン」

Corticotropin-like intermediate peptide
	IUPAC name L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-asparaginyl-L-glycyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-α-glutamyl-L-seryl-L-alanyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-phenylalanine
Identifiers
CAS number	53917-42-3
PubChem	16133227
ChemSpider	14195066
	InChI InChI=1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118); Key: ZYDMZKPAPSZILB-UHFFFAOYSA-N ;
Properties
Molecular formula	C112H165N27O36
Molar mass	2465.668 g/mol
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references

pro-opiomelanocortin
Identifiers
Symbol	POMC
Entrez	5443
HUGO	9201
OMIM	176830
RefSeq	NM_000939
UniProt	P01189
Other data
Locus	Chr. 2 p23

　　[★]

英: melanocyte-stimulating hormone melanocyte stimulating hormone, MSH
同: メラノトロピン melanotropin
関

主にプロオピオメラノコルチン(POMC)が元となって生成される。

1. α-MSH：副腎皮質刺激ホルモン(ACTH) = α-MSH + corticotropin-like intermediate lobe peptide(CLIP)
2. β-MSH：γリポトロピン(γ-LPH)(ヒト、ラット、マウスには存在しないらしい)
3. γ-MSH：POMCのN末端部分(MSH作用は弱いらしい)

「CLIP」

　　[★]

class II-associated invariant chain peptide
コルチコトロピン様中葉ペプチド corticotropin-like intermediate lobe peptide

「コルチコトロピン様中葉ペプチド」

　　[★]

英: corticotropin-like intermediate lobe peptide, CLIP

「like」

　　[★]

v.

好む

prep.

似ている、同様の

関: alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such

「intermediate」

　　[★]

n.

中間体、中間

adj.

中間の、中間部の、中等の、間性の

関: halfway、intermediary、intermediary body、intermedius、intersex、interstitial、interzonal、middle、moderate

「lobe」

　　[★]

n.

葉、ローブ

関: blade、foliage、foliar、leaf、leaves、lobus、plant leaf、plant leaves

「intermediate lobe」

　　[★]

中葉

関: medial lobe、median lobe、middle lamella、middle lamellae、pars intermedia

「intermedia」

　　[★]

Prevotella intermedia、thalassemia intermedia

[pmid227883-1] Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry 254 (23): 11903–6. PMID 227883.

[Fricker1991-2] Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. p. 78. ISBN 978-0-8493-8852-1. Retrieved 25 November 2011.

[NormanLitwack1997-3] Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. p. 12. ISBN 978-0-12-521441-4. Retrieved 25 November 2011.

[Engelking2002-4] Larry Rex Engelking (1 June 2002). Review of veterinary physiology. Teton NewMedia. p. 411. ISBN 978-1-893441-69-9. Retrieved 25 November 2011.

[pmid6209301-5] Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation 74 (5): 1886–9. doi:10.1172/JCI111608 . PMC 425369. PMID 6209301.

[pmid1849784-6] Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O . PMID 1849784.

[Inou.C3.A9Inou.C3.A91989-7] Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. p. 136. ISBN 978-0-8493-4822-8. Retrieved 25 November 2011.

[pmid1981927-8] Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides 15 (2): 61–74. PMID 1981927.

[pmid1964203-9] Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides 15 (2): 75–88. PMID 1964203.

[pmid19529852-10] Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine 147 (3): 319–22. PMID 19529852.

[pmid8134304-11] Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K . PMID 8134304.

リンク元	「メラニン細胞刺激ホルモン」「CLIP」「コルチコトロピン様中葉ペプチド」
関連記事	「like」「intermediate」「lobe」「intermediate lobe」「intermedia」

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案内

案内

corticotropin-like intermediate lobe peptide