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1. 喘息のマネージメントを向上させるトリガー制御trigger control to enhance asthma management [show details]
… that trap heat and moisture when a person breathes out and warm cold air during inhalation may help persons with asthma who work, exercise, or spend time in cold temperatures .… infections (viruses, bacteria) Allergen exposure (inhalant, food, and occupational) Inhaled respiratory irritants (including tobacco and cannabis smoke and cold, dry air) Temperature and weather;… sufficient amounts that highly sensitized patients can develop asthmatic symptoms. As examples, patients sensitive to seafood, egg, or cow milk may react to steam, vapors, or sprays from the cooking or processing …
2. 成人における発熱の病態生理および治療pathophysiology and treatment of fever in adults [show details]
… internal organs, essentially decreasing heat loss from the skin, and the patient feels cold. For most fevers, this is sufficient to raise core body temperature 1 or even 2°C. At the same time, thermogenesis …
3. 寒冷凝集素症cold agglutinin disease [show details]
… core body temperature was the basis for the original description of these antibodies as cold agglutinins . As noted above, CAD can occur in the setting of an underlying viral infection,… due to a cold-sensitive antibody) – Cryoglobulinemia (immunoglobulins that precipitate in the cold; not associated with hemolysis) – There are three major types of cold-sensitive antibodies…
4. 小児における全身性炎症反応症候群（SIRS）および敗血症：定義、疫学、臨床症状、および診断systemic inflammatory response syndrome sirs and sepsis in children definitions epidemiology clinical manifestations and diagnosis [show details]
… cause elevated temperature with tachycardia or hemodynamic instability: Heat stroke – The diagnostic criteria for patients with heatstroke are elevated core temperature (≥40°C [104°F])… Viral pathogens can mimic bacterial sepsis. Etiologies include respiratory viruses (eg, influenza, parainfluenza, adenovirus, respiratory syncytial virus (RSV),… pressures may reflect widening in infants and neonates) Cold shock – "Cold" shock reflects increased systemic vascular resistance…
5. 乳児（生後90日未満）の発熱：発熱の定義febrile infant younger than 90 days of age definition of fever [show details]
… other means of temperature assessment when compared to rectal temperatures in young infants is discussed separately. When ambient temperature and humidity permit normal heat loss (ie,… these young patients can experience significant morbidity from some viral infections. Rectal temperatures are the standard for detecting fever in infants…

English Journal

In vivo assessment of NS1-truncated influenza virus with a novel SLSYSINWRH motif as a self-adjuvanting live attenuated vaccine.

Ngunjiri JM, Ali A, Boyaka P, Marcus PI, Lee CW.
PloS one. 2015 ;10(3)e0118934.
Mutants of influenza virus that encode C-terminally truncated NS1 proteins (NS1-truncated mutants) characteristically induce high interferon responses. The dual activity of interferon in blocking virus replication and enhancing the development of adaptive immune responses makes these mutants promisi
PMID 25790187

[Effect of Point Mutations in the Polymerase Genes of the Influenza A/PR/8/34 (H1N1) Virus on the Immune Response in a Mouse Model].

Kuznetsova SA, Isakova-Sivak IN, Kuznetcova VA, Petukhova GD, Losev IV, Donina SA, Rudenko LG, Naikhin AN.
Voprosy virusologii. 2015 ;60(2)25-30.
The vaccine strains for live attenuated influenza vaccines (LAIVs) have cold-adapted, temperature-sensitive, and attenuated phenotypes, which are guaranteed by the presence of specific mutations from the master donor virus in their internal genes. In this study, we used mutant viruses of the pathoge
PMID 26182653

Engineering temperature sensitive live attenuated influenza vaccines from emerging viruses.

Zhou B, Li Y, Speer SD, Subba A, Lin X, Wentworth DE.
Vaccine. 2012 May;30(24)3691-702.
The licensed live attenuated influenza A vaccine (LAIV) in the United States is created by making a reassortant containing six internal genes from a cold-adapted master donor strain (ca A/AA/6/60) and two surface glycoprotein genes from a circulating/emerging strain (e.g., A/CA/7/09 for the 2009/201
PMID 22449422