coagulation factor VIIIa

• 活性化凝固第VIII因子、活性化第VIII因子

関

activated factor VIII、factor VIIIa

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 凝固,凝結

UpToDate Contents

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• 1. 第VIII因子および第IX因子の生物学と正常な機能 biology and normal function of factor viii and factor ix
• 2. 肝臓の合成能の検査（アルブミン、凝固因子、プロトロンビン時間など） tests of the livers biosynthetic capacity eg albumin coagulation factors prothrombin time
• 3. 血漿分画製剤および組換えDNA産生凝固因子 plasma derivatives and recombinant dna produced coagulation factors
• 4. 止血の概要 overview of hemostasis
• 5. 後天性の凝固因子阻害物質 acquired inhibitors of coagulation

English Journal

• Asymptomatic type B right atrial thrombus in a case with protein S deficiency.

• Rawat RS, Mehta Y1, Arora D, Trehan N.
• Annals of cardiac anaesthesia.Ann Card Anaesth.2014 July-September;17(3):237-239. doi: 10.4103/0971-9784.135877.
• Thirty seven year old asymptomatic male underwent routine medical examination which revealed an abnormal mass in the right atrium. Family history was not suggestive of any cardiac or malignant disease. Detailed investigation detected deficiency of protein S, which is a vitamin K dependent protein an
• PMID 24994736

• Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C.

• Somajo S1, Koshiar RL1, Norström E1, Dahlbäck B2.
• Thrombosis research.Thromb Res.2014 Jul;134(1):144-52. doi: 10.1016/j.thromres.2014.04.031. Epub 2014 May 2.
• INTRODUCTION: Platelets are the main source of microparticles in plasma and the concentration of microparticles is increased in many diseases. As microparticles expose negatively charged phospholipids, they can bind and assemble the procoagulant enzyme-cofactor complexes. Our aim was to elucidate po
• PMID 24835672

• Role of hydrophobic mutations on the binding affinity and stability of blood coagulation factor VIIIa: A computational molecular dynamics and free-energy analysis.

• Venkateswarlu D.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Jun 18. pii: S0006-291X(14)01117-6. doi: 10.1016/j.bbrc.2014.06.043. [Epub ahead of print]
• Factor VIIIa is a non-covalently bound hetero-trimer among A1, A2 and A3-C1-C2 domains and an essential co-factor for factor IXa enzyme during proteolytic activation of factor X zymogen. The relatively weak interactions between A2 and the interface A1/A3 domains dampen the functional stability of FV
• PMID 24952158

Japanese Journal

• 血栓症を発症した複合ヘテロ接合体性プロテインＣ欠乏症患者で認められた２種の遺伝子変異とそれぞれのプロテインＣ産生に及ぼす影響

• 油井 知雄,越智 守生,高橋 伸彦,家子 正裕,林 辰弥,鈴木 宏治
• 日本血栓止血学会誌 22(3), 87-99, 2011
• プロテインC（PC）はビタミンK依存性のセリンプロテアーゼ前駆体であり，先天性PC欠乏症は静脈系血栓症の発症に関与する．本研究ではPC欠乏症と診断された家系の発端者PC遺伝子についてPCR-Direct sequence法によりPC遺伝子上の変異部位を同定するとともに，PCR-Restriction fragment length polymorphism（RFLP）法により，その家系の遺伝子型の …
• NAID 130000823243

• An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa

• GALE AJ
• J Thromb Haemost. 1, 1966-1971, 2003
• NAID 30005079981

• 活性化 IX 因子の結晶構造

• 濱本 高義,副島 見事,岩永 貞昭
• 日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis 10(4), 290-298, 1999-08-01
• NAID 10008633826

Related Links

• DrugBank: Coagulation factor VIIa

Identification Name Coagulation factor VIIa Accession Number DB00036 (BIOD00006, BTD00006) Type Biotech Groups Approved Description Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis ...

• Coagulation Factor VIIIa as an Agent - xPharm: The ...

Factor VIII (antihemophilic factor) is an important component in the intrinsic pathway of blood coagulation. Its active form, factor VIIIa, acts as a co-factor ... Comments Factor VIII is synthesized primarily in the liver and is released into ...

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★リンクテーブル★

リンク元	「活性化第VIII因子」「factor VIIIa」「activated factor VIII」「活性化凝固第VIII因子」
関連記事	「fact」「factor」「factor VIIIa」「coagulation factor」

「活性化第VIII因子」

　　[★]

英

factor VIIIa、activated factor VIII、coagulation factor VIIIa

関

活性化凝固第VIII因子

「factor VIIIa」

　　[★]

活性化第VIII因子

関

activated factor VIII、coagulation factor VIIIa

「activated factor VIII」

　　[★]

活性化第VIII因子

関

coagulation factor VIIIa、factor VIIIa

「活性化凝固第VIII因子」

　　[★]

英

coagulation factor VIIIa

関

活性化第VIII因子

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「factor VIIIa」

　　[★]

活性化第VIII因子

関

activated factor VIII、coagulation factor VIIIa

「coagulation factor」

　　[★] 血液凝固因子

同

coagulation factors