For information about the head portion in arthropod anatomy, see cephalon (arthropod head).
Cephalon, Inc.
|
Type
|
Subsidiary of Teva Pharmaceutical Industries |
| Industry |
Biotechnology, Biopharmaceutical |
| Founded |
1987 |
| Headquarters |
Frazer, Pennsylvania, United States |
|
Key people
|
J. Kevin Buchi, CEO |
| Products |
medical development |
|
Number of employees
|
3,726 (as of December 31, 2010) |
| Slogan |
Deliver more |
| Website |
www.cephalon.com |
Cephalon, Inc. was a U.S. biopharmaceutical company co-founded in 1987 by Dr. Frank Baldino, Jr., a pharmacologist and former scientist with the DuPont Company, who served as the company's chairman and chief executive officer until his death in December 2010.[1] The company's name comes from the adjective "cephalic" meaning "related to the head or brain," and it was established primarily to pursue treatments for neurodegenerative diseases.
Sales revenues reached $2.8 billion in 2010, ranking Cephalon among the leading biopharmaceutical companies in the world. In 2006, industry publication MedAd News named the company one of the ten most respected biotechnology firms in the world. Cephalon employs more than 3,700.
Cephalon was first included in the Fortune 1000 list of U.S. companies based upon annual revenues for 2006.
On May 2, 2011, Teva announced its acquisition of Cephalon.[2]
Contents
- 1 Background
- 2 Locations
- 3 Management
- 4 Legal Issues
- 5 Products
- 6 References
- 7 External links
Background
The company's early research efforts were focused on the development of IGF-1, an insulin-like growth factor, under a collaboration with Chiron Corporation to treat amyotrophic lateral sclerosis, or Lou Gehrig's Disease, but the product has never been approved.
The company developed and commercialized products for the treatment of sleep disorders, pain, addiction and cancer, establishing the "wake franchise" on the basis of Provigil (Modafinil) and later Nuvigil, with the R-enantiomer of modafinil. In addition to conducting research on kinase inhibitors and other small molecules, it has licensed compounds and acquired both products and other companies, including CIMA Labs, Anesta, and Laboratoire Lafon. It was from the latter company that Cephalon obtained the rights to modafinil, which it marketed under the trade name Provigil for the treatment of excessive daytime sleepiness associated with narcolepsy, sleep apnea and shift work sleep disorder.[1] Sales of Provigil reached nearly one billion dollars in 2008, by which time the company had acquired Lafon.
In February 2009, Cephalon announced its intention to acquire Australian biotechnology firm Arana Therapeutics, a move that represented one of the largest changes in the Australian life sciences landscape. The acquisition of Arana brought Cephalon its lead biologic candidate ART621 for inflammatory diseases. Moreover, Cephalon acquired biologics for the treatment of cancers. In February 2010, Cephalon exercised its option to acquire Ception Therapeutics, following receipt of positive data from a clinical study in adults with eosinophilic asthma. Commenting on this Frank Baldino, Jr, the CEO of Cephalon, said “The acquisition of Ception is consistent with our strategy to diversify into biologics and provides us with an important phase three asset for further development.” [3]
Cephalon acquired ChemGenex Pharmaceuticals, which provided Cephalon with marketing rights to Omapro, a therapeutic agent for drug-resistant CML.[4]
Locations
The company was headquartered west of Philadelphia in Frazer, Pennsylvania and had research operations in nearby West Chester, as well as manufacturing and other operations in suburban Minneapolis, Minnesota and Salt Lake City, Utah; its European operations were based near Paris, France.
Management
Longtime chief financial officer J. Kevin Buchi succeeded Baldino as CEO in 2011. Members of the board included venture capitalist William Egan, former COR Therapeutics CEO Vaughan Kailian, prominent healthcare economist Dr. Gail Wilensky, former SmithKline Beecham executive Dr. Martyn Greenacre, former Harvard physician and Glaxo USA head Dr. Charles Sanders and former Ambassador Kevin Moley.
Legal Issues
Cephalon settled a lawsuit for $17 million in which it faced claims that Baldino and other company executives had overstated the potential for a drug aimed at treating amyotrophic lateral sclerosis (known informally as Lou Gehrig's disease).[5] The Federal Trade Commission claimed that Cephalon had made improper deals to postpone the availability of generic versions of modafinil.[1] In September 2008, Cephalon paid $425 million to the federal government to settle four whistleblower lawsuits and a criminal charge alleging Cephalon had marketed Actiq, Gabitril and Provigil for “off-label” (unapproved) uses.[6]
Products
Select products that Cephalon manufactures and markets include:
- Actiq (fentanyl citrate) - Cancer pain
- Amrix (cyclobenzaprine) - Muscle relaxant
- Fentora (fentanyl) - Cancer pain
- Gabitril (tiagabine) - Seizures
- Nuvigil (armodafinil) - Narcolepsy
- Provigil (modafinil) - Narcolepsy
- Treanda (bendamustine) - Indolent B-cell non-Hodgkin's lymphoma (NHL) and Chronic lymphocytic leukemia
- Trisenox (arsenic trioxide) - Acute promyelocytic leukemia treatment
References
- ^ a b c Meier, Barry. "Frank Baldino Jr., Founder of Pharmaceutical Company, Dies at 57", The New York Times, December 21, 2010. Retrieved December 24, 2010.
- ^ http://maya.tase.co.il/bursa/report.asp?report_cd=639962-00&Type=Pdf
- ^ Cephalon To Acquire Ception Therapeutics. Archived 1 February 2011 at WebCite
- ^ Bennett, Simeon (March 29, 2011), "Cephalon agrees to acquire ChemGenex: Potential leukemia drug key to $230M purchase", Delaware Online (Bloomberg News), retrieved March 30, 2011
- ^ "Cephalon, Inc. - Company Profile, Information, Business Description, History, Background Information on Cephalon, Inc.". Referenceforbusiness.com. Retrieved April 18, 2012.
- ^ "Cephalon pays $425 million to settle unique off-label marketing case brought by whistleblower", Phillips and Cohen LLP Press Release, September 29, 2008.
External links
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Philadelphia-area corporations (including the Delaware Valley)
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List of companies based in the Philadelphia area
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Philadelphia-based Fortune 500
corporations (rank in the 2015 list) |
- Comcast (43)
- Aramark (207)
- Crown Holdings (318)
|
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Delaware Valley-based Fortune 500
corporations (rank in the 2015 list) |
- AmerisourceBergen (16)
- DuPont (87)
- Lincoln National (223)
- Campbell Soup (342)
- Universal Health Services (324)
- UGI (349)
|
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Other notable Philadelphia-based
businesses |
- Amoroso's
- Beneficial Bank
- Chemtura
- Day & Zimmermann
- FMC Corporation
- Independence Blue Cross
- Pennsylvania Real Estate Investment Trust
- Pep Boys
- Philadelphia Media Network
- Radian Group
- Urban Outfitters
|
|
Notable Philadelphia-based
professional partnerships |
- Ballard Spahr
- Blank Rome
- Cozen O'Connor
- Dechert
- Drinker Biddle & Reath
- Duane Morris
- Morgan, Lewis & Bockius
- Pepper Hamilton
- Saul Ewing
- White and Williams
|
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Other notable Delaware
Valley-based businesses |
- Airgas
- AlliedBarton
- Ametek
- Aqua America
- Asplundh
- Bentley Systems
- Brandywine Realty Trust
- Boenning & Scattergood
- Boscov's
- Burlington Coat Factory
- Carpenter Technology
- Cephalon
- Chemours
- Christiana Care Health System
- Crozer Keystone Health System
- David's Bridal
- EPAM Systems
- EnerSys
- Hamilton Lane
- Liberty Property Trust
- Penn Mutual
- Penn National Gaming
- Rita's Italian Ice
- SEI Investments
- SLM
- SunGard
- Susquehanna International Group
- Vanguard
- Toll Brothers
- Triumph Group
- Unisys
- ViroPharma
- Vishay Intertechnology
- VWR
- Wawa
- Wilmington Trust
- W. L. Gore and Associates
- WSFS Bank
|
|
Notable Delaware Valley-based
US headquarters of
foreign businesses |
- Aberdeen Asset Management
- ACE
- AgustaWestland
- AstraZeneca
- Delaware Investments
- GlaxoSmithKline
- HSBC Bank USA
- ING Group
- Keystone Foods
- SAP America
- Siemens Medical
- Shire Pharmaceuticals
- Subaru
- Teva Pharmacueticals
- TD Bank
|
|
Notable Delaware Valley-based
division headquarters of
US corporations |
- Acme (Cerberus Capital Management)
- Centocor (Johnson & Johnson)
- Colonial Penn (Conseco)
- Delmarva Power (Pepco Holdings)
- GSI Commerce (eBay)
- Hercules (Ashland)
- MAB Paints (Sherwin-Williams)
- McNeil Laboratories (J&J)
- Neoware (Hewlett-Packard)
- PECO (Exelon)
- QVC (Liberty Media)
- Rohm and Haas (Dow Chemical)
- Sunoco (Energy Transfer)
- Tasty Baking (Flowers Foods)
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Pharmaceutical companies of the United States
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- List of pharmaceutical companies
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