WordNet
- (geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
- mold used in the production of phonograph records, type, or other relief surface
- the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
- (mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
- an enclosure within which something originates or develops (from the Latin for womb)
- the formative tissue at the base of a nail
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- a fibrous band of scar tissue that binds together normally separate anatomical structures
- abnormal union of bodily tissues; most common in the abdomen
PrepTutorEJDIC
- （複数形 matrices, ～・es）(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文 （matrix sentence）
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 粘着,付着
- マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)
UpToDate Contents
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- 1. 鎌状赤血球症における血管閉塞症 vasoocclusion in sickle cell disease
- 2. 全身性硬化症（強皮症）の病因 pathogenesis of systemic sclerosis scleroderma
- 3. 移植免疫 transplantation immunobiology
- 4. 肝線維症の病因 pathogenesis of hepatic fibrosis
- 5. 適応細胞性免疫応答 the adaptive cellular immune response
English Journal
- Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation.
- Alique M1, Civantos E1, Sanchez-Lopez E1, Lavoz C1, Rayego-Mateos S1, Rodrigues-Díez R1, García-Redondo AB1, Egido J2, Ortiz A3, Rodríguez-Puyol D4, Rodríguez-Puyol M5, Ruiz-Ortega M1.Author information 1*Cellular Biology in Renal Diseases Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma Madrid, Madrid, Spain.2†Renal Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma Madrid, CIBERDEM, Madrid, Spain.3‡Dialysis Unit, IIS-Fundación Jiménez Díaz, Universidad Autónoma Madrid, Madrid, Spain.4§Nephrology Section, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain.5¶Physiology Department, Universidad de Alcalá, Madrid, Spain.AbstractILK (integrin-linked kinase) is an intracellular serine/threonine kinase involved in cell-matrix interactions. ILK dysregulation has been described in chronic renal disease and modulates podocyte function and fibrosis, whereas data about its role in inflammation are scarce. AngII (angiotensin II) is a pro-inflammatory cytokine that promotes renal inflammation. AngII blockers are renoprotective and down-regulate ILK in experimental kidney disease, but the involvement of ILK in the actions of AngII in the kidney has not been addressed. Therefore we have investigated whether ILK signalling modulates the kidney response to systemic AngII infusion in wild-type and ILK-conditional knockout mice. In wild-type mice, AngII induced an inflammatory response, characterized by infiltration of monocytes/macrophages and lymphocytes, and up-regulation of pro-inflammatory factors (chemokines, adhesion molecules and cytokines). AngII activated several intracellular signalling mechanisms, such as the NF-κB (nuclear factor κB) transcription factor, Akt and production of ROS (reactive oxygen species). All these responses were prevented in AngII-infused ILK-deficient mice. In vitro studies characterized further the mechanisms regulating the inflammatory response modulated by ILK. In cultured tubular epithelial cells ILK blockade, by siRNA, inhibited AngII-induced NF-κB subunit p65 phosphorylation and its nuclear translocation. Moreover, ILK gene silencing prevented NF-κB-related pro-inflammatory gene up-regulation. The results of the present study demonstrate that ILK plays a key role in the regulation of renal inflammation by modulating the canonical NF-κB pathway, and suggest a potential therapeutic target for inflammatory renal diseases.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jul;127(1):19-31. doi: 10.1042/CS20130412.
- ILK (integrin-linked kinase) is an intracellular serine/threonine kinase involved in cell-matrix interactions. ILK dysregulation has been described in chronic renal disease and modulates podocyte function and fibrosis, whereas data about its role in inflammation are scarce. AngII (angiotensin II) is
- PMID 24383472
- Osteoactivin Induces Transdifferentiation of C2C12 Myoblasts Into Osteoblasts.
- Sondag GR1, Salihoglu S, Lababidi SL, Crowder DC, Moussa FM, Abdelmagid SM, Safadi FF.Author information 1Department of Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio; School of Biomedical Sciences, Kent State University, Kent, Ohio.AbstractOsteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and function. Previous studies showed that OA stimulates matrix mineralization and transcription of osteoblast specific genes required for differentiation. OA plays a role in wound healing and its expression was shown to increase in post fracture calluses. OA expression was reported in muscle as OA is upregulated in cases of denervation and unloading stress. The regulatory mechanisms of OA in muscle and bone have not yet been determined. In this study, we examined whether OA plays a role in transdifferentiation of C2C12 myoblast into osteoblasts. Infected C2C12 with a retroviral vector overexpressing OA under the CMV promoter were able to transdifferentiate from myoblasts into osteoblasts. Immunofluorescence analysis showed that skeletal muscle marker MF-20 was severely downregulated in cells overexpressing OA and contained significantly less myotubes compared to uninfected control. C2C12 myoblasts overexpressing OA showed an increase in expression of bone specific markers such as alkaline phosphatase and alizarin red staining, and also showed an increase in Runx2 protein expression. We also detected increased levels of phosphorylated focal adhesion kinase (FAK) in C2C12 myoblasts overexpressing OA compared to control. Taken together, our results suggest that OA is able to induce transdifferentiation of myoblasts into osteoblasts through increasing levels of phosphorylated FAK. J. Cell. Physiol. 229: 955-966, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular physiology.J Cell Physiol.2014 Jul;229(7):955-66. doi: 10.1002/jcp.24512.
- Osteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and function. Previous studies showed that OA stimulates matrix mineralization and transcription of osteoblast specific genes required for differentiation. OA plays a role in wound healing and its expression was
- PMID 24265122
- Carbon nanotube-based substrates for modulation of human pluripotent stem cell fate.
- Pryzhkova MV1, Aria I2, Cheng Q3, Harris GM1, Zan X4, Gharib M2, Jabbarzadeh E5.Author information 1Department of Chemical Engineering, University of South Carolina, SC 29208, USA.2Graduate Aeronautics Laboratories, California Institute of Technology, CA 91125, USA.3Department of Biomedical Engineering, University of South Carolina, SC 29208, USA.4Department of Chemistry and Biochemistry, University of South Carolina, SC 29208, USA.5Department of Chemical Engineering, University of South Carolina, SC 29208, USA; Department of Biomedical Engineering, University of South Carolina, SC 29208, USA; Department of Orthopaedic Surgery, University of South Carolina, SC 29208, USA. Electronic address: jabbarza@cec.sc.edu.AbstractWe investigated the biological response of human pluripotent stem cells (hPSCs) cultured on a carbon nanotube (CNT) array-based substrate with the long term goal to direct hPSC germ layer specification for a wide variety of tissue engineering applications. CNT arrays were fabricated using a chemical vapor deposition system allowing for control over surface roughness and mechanical stiffness. Our results demonstrated that hPSCs readily attach to hydrophilized and extracellular matrix coated CNT arrays. hPSCs cultured as colonies in conditions supporting self-renewal demonstrated the morphology and marker expression of undifferentiated hPSCs. Conditions inducing spontaneous differentiation lead to hPSC commitment to all three embryonic germ layers as assessed by immunostaining and RT-PCR analysis. Strikingly, the physical characteristics of CNT arrays favored mesodermal specification of hPSCs. This is contradictory to the behavior of hPSCs on traditional tissue culture plastic which promotes the development of ectoderm. Altogether, these results demonstrate the potential of CNT arrays to be used in the generation of new platforms that allow for precise control of hPSC differentiation by tuning the characteristics of their physical microenvironment.
- Biomaterials.Biomaterials.2014 Jun;35(19):5098-109. doi: 10.1016/j.biomaterials.2014.03.011. Epub 2014 Mar 29.
- We investigated the biological response of human pluripotent stem cells (hPSCs) cultured on a carbon nanotube (CNT) array-based substrate with the long term goal to direct hPSC germ layer specification for a wide variety of tissue engineering applications. CNT arrays were fabricated using a chemical
- PMID 24690530
Japanese Journal
- (2)卵巣癌の予後規程因子の同定とそれに基づく新たな分子標的治療の開発 : 腹膜播種の抑制に焦点を合わせて(<特集>第61回学術講演会シンポジウム3「卵巣癌の新たな治療戦略-基礎から,そして臨床から-」)
- 澤田 健二郎
- 日本産科婦人科學會雜誌 61(11), 2027-2041, 2009-11-01
- … Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that downregulation of E-cadherin would affect expression of cell-matrix adhesion receptors. … Next, we focused on hepatocyte growth factor receptor, c-Met, a receptor tyrosine kinase that plays an important role in tumor growth by activating mitogenic signaling pathways and regulating adhesion and invasion. …
- NAID 110007467574
- オステオポンチンは悪性胸膜中皮腫の細胞機能に影響を与える
- 大橋 里奈,田島 健,崔 日,顧 涛,樋野 興夫,塩見 和,宮元 秀昭,西尾 和人,高橋 和久
- 肺癌 49(4), 368-375, 2009
- … 相化したOPNと細胞株との接着，増殖試験を抗αvβ3抗体もしくはArginine-Glycine-Aspartic acid（RGD）ペプチドの添加·非添加の条件下で行った．同様にOPN上でのアポトーシスと遊走能の評価と固相化OPN上におけるfocal adhesion kinase（FAK）のリン酸化を検討した．結果．Reverse transcriptase-polymerase chain reaction（RT-PCR）の結果，肉腫型胸膜中皮腫細胞株でOPNの発現を認めた．同様にFACScanTMではαvとβ3の発現とOPNに対しての接着，増殖の増 …
- NAID 130000122999
- Thy-1分子が歯肉線維芽細胞のコラーゲン貪食に及ぼす作用
- 高野 顕一,小林 誠,宮田 昌和 [他],村山 怜一郎,山本 松男
- Dental medicine research 28(2), 77-86, 2008-07-31
- … 細胞細胞間や細胞細胞外基質問の相互関係の重要な制御因子であると考えられている.本研究では, Thy-1がヒト歯肉線維芽細胞 (HGF) のコラーゲン貧食に及ぼす作用とその機序について検討した.HGFからmagnetic cell sortingでThy-1陽性細胞率が高い細胞集団 (Thy-1<SUP>High</SUP>HGF) とThy-1陽性細胞率が低い集団 (Thy-1<SUP>low</SUP>HGF) を分取し, コラーゲンでコートした蛍光発色ポリスチレンビーズ (コラーゲンビーズ) …
- NAID 10024381984
Related Links
- Integrins are the principle cell surface adhesion receptors mediating cell–matrix adhesion. Integrins are heterodimeric receptors generated by selective pairing between 18 α and 8 β subunits; there are 24 distinct integrin receptors that ...
- Page 1 Cell–Matrix Adhesion ALLISON L. BERRIER1,2*AND KENNETH M. YAMADA2* 1Katrina Visiting Faculty Program, National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland
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★リンクテーブル★
| リンク元 | 「細胞マトリックス接着」「細胞基質間接着」「cell-matrix junction」 |
| 関連記事 | 「adhesion」「cell」 |
「細胞マトリックス接着」
「細胞基質間接着」
「cell-matrix junction」
「adhesion」
- n