WordNet

pierce with a pointed object; make a hole into; "puncture a tire"
be pierced or punctured; "The tire punctured"
cause to lose air pressure or collapse by piercing; "puncture an air balloon"
a small hole made by a sharp object
the act of puncturing or perforating
loss of air pressure in a tire when a hole is made by some sharp object
make by piercing; "puncture a hole"
(surgery) tying a duct or blood vessel with a ligature (as to prevent bleeding during surgery)
of or like a cecum (同)caecal

PrepTutorEJDIC

《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
(とがったもので)…‘に'穴をあける,‘を'パンクさせる《+『名』+『with』+『名』》 / 〈穴など〉‘を'あける / …‘を'パチンと壊す / (とがったものでできた)穴 / (とがったもので)穴をあけること;(タイヤの)パンク
(次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)

UpToDate Contents

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1. 内視鏡的静脈瘤結紮術 endoscopic variceal ligation
2. 盲腸軸捻転症 cecal volvulus
3. 虚血後（虚血性）の急性尿細管壊死において考え得る予防および治療 possible prevention and therapy of postischemic ischemic acute tubular necrosis
4. 女性の避妊手術 surgical sterilization of women
5. 下肢静脈アブレーションのための開放手術法 open surgical techniques for lower extremity vein ablation

English Journal

Barrier protective effects of rosmarinic acid on HMGB1-induced inflammatory responses in vitro and in vivo.

Yang EJ, Ku SK, Lee W, Lee S, Lee T, Song KS, Bae JS.SourceBK21 Research Team for Developing Functional Health Food Materials, Kyungpook National University, Republic of Korea.
Journal of cellular physiology.J Cell Physiol.2013 May;228(5):975-82. doi: 10.1002/jcp.24243.
High mobility group box 1 (HMGB1) protein is a crucial cytokine that mediates response to infection, injury, and inflammation. Rosmarinic acid (RA) is an important component of the leaves of Perilla frutescens and has neuroprotective, anti-microbial, anti-oxidant, and anti-cancer effects but little
PMID 23042518

Persicarin is anti-inflammatory mediator against HMGB1-induced inflammatory responses in HUVECs and in CLP-induced sepsis mice.

Kim TH, Ku SK, Bae JS.SourceDepartment of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan, Republic of Korea.
Journal of cellular physiology.J Cell Physiol.2013 Apr;228(4):696-703. doi: 10.1002/jcp.24214.
High mobility group box 1 (HMGB1) protein is a crucial nuclear cytokine that mediates inflammatory responses, whereas persicarin is an active compound from Oenanthe javanica that has been widely researched for its neuroprotective and antioxidant activities. However, little is known of the effects of
PMID 22911316

Inhibitory effects of epi-sesamin on HMGB1-induced vascular barrier disruptive responses in vitro and in vivo.

Lee W, Ku SK, Kim JA, Lee T, Bae JS.SourceCollege of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2013 Mar 15;267(3):201-8. doi: 10.1016/j.taap.2013.01.008. Epub 2013 Jan 23.
Nuclear DNA-binding protein high mobility group box 1 (HMGB1) protein acts as a late mediator of severe vascular inflammatory conditions, such as sepsis and septic shock. Epi-sesamin (ESM), an important component of Asarum sieboldii roots, is known to exhibit anti-allergic, anti-nociceptive, and ant
PMID 23352503

Japanese Journal

<原著>ラット敗血症モデルにおけるCitrulline-NO cycleとシトルリン補充療法の有用性の検討

木村浩基,前川昌平,米倉竹夫,保木昌徳,朴雅美,森下祐次,八木誠,竹山宜典,奥野清隆
近畿大学医学雑誌 39(3-4), 105-113, 2014-12
… 方法 : 敗血症モデルとして盲腸結紮穿刺（Cecal ligation and puncture : CLP）ラットを用い, シトルリン（Cit群）, アルギニン（Arg 群）, アラニン（Ala群）を添加した維持輸液を行い, 実験 I では処置後5日間生存率を検討し, 実験IIでは処置後2日目の肝, 腎, 回腸でのシトルリン代謝関連酵素の発現および組織学的検討を行った. …
NAID 120005539608

The manner of the inflammation-boosting effect caused by acute hyperglycemia secondary to overfeeding and the effects of insulin therapy in a rat model of sepsis

Yoneyama Satoshi,Terashima Hideo,Yamaguchi Ryushiro,Tadano Sosuke,Ohkohchi Nobuhiro
Journal of surgical research 185(1), 380-387, 2013-11
… BackgroundThe aim of the study was to investigate both the inflammation-boosting effect and the metabolic stress induced by acute hyperglycemia secondary to overfeeding with excessive glucose infusion and the effects of insulin therapy on those events in a rat model of sepsis.Materials and methodsSprague–Dawley rats underwent cecal ligation and puncture (CLP) or sham operation. …
NAID 120005350269

Enhanced Liver Autophagic Activity Improves Survival of Septic Mice Lacking Surfactant Proteins A and D

Tang Zhe,Ni Lan,Javidiparsijani Sara,Hu Fengqi,A Gatto Louis,Cooney Robert,Wang Guirong
The Tohoku Journal of Experimental Medicine 231(2), 127-138, 2013
… Surfactant protein A and D (SP-A and SP-D) are involved in host defense, regulation of inflammation, and homeostasis, but their roles in the autophagic activity and relevant gene expression in sepsis are unclear. …
NAID 130004460089