UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ST上昇型心筋梗塞の非急性期マネージメントの概要overview of the non acute management of st elevation myocardial infarction [show details]
…II cardiac rehabilitation program. Psychosocial stress factors are associated with a poor prognosis after acute MI, and reducing emotional stress may improve outcomes. Multifactorial cardiac rehabilitation… We do not recommend hematopoietic stem cell therapy for patients with acute myocardial infarction except as part of an investigational study.…
2. 幹細胞の概要overview of stem cells [show details]
…ophthalmology. The presence of stem cells in other tissue types has led to the preclinical testing of stem cell therapies for other disorders, including those involving muscle and nerve tissue. The potential use of …
3. 成人における急性肝不全：マネージメントおよび予後acute liver failure in adults management and prognosis [show details]
… percent). Despite the potential benefits, hypothermia can also increase the risk of infection, cardiac dysrhythmias, and bleeding, all of which are known complications of acute liver failure . As a result… although they may have a potential role in severe autoimmune hepatitis Hepatic regeneration therapy using insulin and glucagon ; Charcoal hemoperfusion ; Prostaglandin E,…
4. 下肢末梢動脈疾患の概要overview of lower extremity peripheral artery disease [show details]
… of patients who did not undergo surgery. There was a lower incidence of complications, including cardiac complications (8 versus 27 percent), bladder/bowel complications (33 versus 55 percent), and delirium…patients. Therapies that have been investigated include prostaglandins, therapeutic angiogenesis, stem cell therapy, and spinal cord stimulation; however, none of these are recommended. The presence of ischemic …
5. クローン病の内科的マネージメントにおける試験研究治療investigational therapies in the medical management of crohn disease [show details]
…autologous stem cell transplantation ( [ASTIC]) was halted prematurely for safety reasons. Stem cell therapy has been evaluated in patients with treatment-refractory complex perianal fistulas . In a randomized…

English Journal

Engineering a naturally-derived adhesive and conductive cardiopatch.

Walker BW, Lara RP, Yu CH, Sani ES, Kimball W, Joyce S, Annabi N.
Biomaterials. 2019 Jul;207()89-101.
Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered card
PMID 30965152

Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.

Haginiwa S, Sadahiro T, Kojima H, Isomi M, Tamura F, Kurotsu S, Tani H, Muraoka N, Miyake N, Miyake K, Fukuda K, Ieda M.
Biochemical and biophysical research communications. 2019 Jun;513(4)1041-1047.
Cardiovascular disease is a leading cause of death worldwide. Mammalian cardiomyocytes (CMs) proliferate during embryonic development, whereas they largely lose their regenerative capacity after birth. Defined factors expressed in cardiac progenitors or embryonic CMs may activate the cell cycle and
PMID 31010673

Excessive inflammation impairs heart regeneration in zebrafish breakdance mutant after cryoinjury.

Xu S, Liu C, Xie F, Tian L, Manno SH, Manno FAM, Fallah S, Pelster B, Tse G, Cheng SH.
Fish & shellfish immunology. 2019 Jun;89()117-126.
Inflammation plays a crucial role in cardiac regeneration. Numerous advantages, including a robust regenerative ability, make the zebrafish a popular model to study cardiovascular diseases. The zebrafish breakdance (bre) mutant shares several key features with human long QT syndrome that predisposes
PMID 30928664

Japanese Journal

心筋の直接誘導

萩庭頌,家田真樹
循環器内科 = Cardioangiology 85(2), 273-279, 2019-02
NAID 40021813424

STAT3 Phosphorylation Mediating DMSO's Function on Fetal Cardiomyocyte Proliferation with Developmental Changes

Hu Haitao,Xue Jin,Dong Renshun,Zhao Yanan,Song Chunyan,Zhao Hongjian,Hescheler Jürgen,Zhang Yan,Liang Huamin
International Heart Journal 60(2), 392-399, 2019
… <p>Endogenous cardiac regeneration has been focused for decades as a potential therapy for heart diseases with cell loss, and dimethyl sulfoxide (DMSO) has been proposed as a treatment for many diseases. … Therefore, DMSO could serve as an effective, economic, and safe therapy for heart diseases with cell loss.</p> …
NAID 130007616944

Rabbit induced pluripotent stem cells retain capability of <i>in vitro</i> cardiac differentiation

PHAKDEEDINDAN Praopilas,SETTHAWONG Piyathip,TIPTANAVATTANA Narong,RUNGARUNLERT Sasitorn,INGRUNGRUANGLERT Praewphan,ISRASENA Nipan,TECHAKUMPHU Mongkol,THARASANIT Theerawat
実験動物彙報 68(1), 35-47, 2019
… Rabbit model has essentially used for cardiovascular diseases and regeneration but information on establishment of induced pluripotent stem cells (iPSCs) and differentiation potential is fairly limited. … In addition, there is no report of cardiac differentiation from iPSCs in the rabbit model. … The cell density at 20,000 cells per EB was selected for cardiac differentiation. …
NAID 130007604454