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1. 幹細胞の概要overview of stem cells [show details]
… animal models of retinal blindness, Parkinson disease, Huntington disease, spinal cord injury, myocardial infarction, and type I diabetes mellitus. Human ES cell-derived retinal photoreceptors have been … The presence of stem cells in other tissue types has led to the preclinical testing of stem cell therapies for other disorders,…
2. ST上昇型心筋梗塞の非急性期マネージメントの概要overview of the non acute management of st elevation myocardial infarction [show details]
… topic is discussed in detail separately. We do not recommend hematopoietic stem cell therapy for patients with acute myocardial infarction except as part of an investigational study. It has not been associated …
3. 下肢末梢動脈疾患の概要overview of lower extremity peripheral artery disease [show details]
…aimed at reducing the risk for future cardiovascular events related to atherosclerosis, such as myocardial infarction, stroke, and peripheral arterial events. These therapies are also particularly important … patients. Therapies that have been investigated include prostaglandins, therapeutic angiogenesis, stem cell therapy, and spinal cord stimulation; however, none of these are recommended. The presence of ischemic …
4. 狭心症の新しい治療法new therapies for angina pectoris [show details]
…cardiac neurons to generate activity during myocardial ischemia ; alternatively, it may provide benefit by reducing sympathetic activity or by redistributing myocardial blood flow from nonischemic to ischemic …
5. クローン病の内科的マネージメントにおける試験研究治療investigational therapies in the medical management of crohn disease [show details]
…autologous stem cell transplantation ( [ASTIC]) was halted prematurely for safety reasons. Stem cell therapy has been evaluated in patients with treatment-refractory complex perianal fistulas . In a randomized…

English Journal

Engineering a naturally-derived adhesive and conductive cardiopatch.

Walker BW, Lara RP, Yu CH, Sani ES, Kimball W, Joyce S, Annabi N.
Biomaterials. 2019 Jul;207()89-101.
Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered card
PMID 30965152

Excessive inflammation impairs heart regeneration in zebrafish breakdance mutant after cryoinjury.

Xu S, Liu C, Xie F, Tian L, Manno SH, Manno FAM, Fallah S, Pelster B, Tse G, Cheng SH.
Fish & shellfish immunology. 2019 Jun;89()117-126.
Inflammation plays a crucial role in cardiac regeneration. Numerous advantages, including a robust regenerative ability, make the zebrafish a popular model to study cardiovascular diseases. The zebrafish breakdance (bre) mutant shares several key features with human long QT syndrome that predisposes
PMID 30928664

Circulatory support and stem cell therapy in the management of advanced heart failure: a concise review of available evidence.

Hussain MA, Colicchia M, Veerapen J, Weeraman D, Podaru MN, Jones D, Suzuki K, Mathur A.
Regenerative medicine. 2019 May;().
Stem cell therapy utilizing bone marrow mononuclear cells (BMC's) is a potential strategy to treat heart failure patients with improvement in symptom profile and cardiac function. We describe a rationale for concurrent BMC and left ventricular assist device therapy in selected heart failure patients
PMID 31115248

Japanese Journal

Rabbit induced pluripotent stem cells retain capability of <i>in vitro</i> cardiac differentiation

PHAKDEEDINDAN Praopilas,SETTHAWONG Piyathip,TIPTANAVATTANA Narong,RUNGARUNLERT Sasitorn,INGRUNGRUANGLERT Praewphan,ISRASENA Nipan,TECHAKUMPHU Mongkol,THARASANIT Theerawat
実験動物彙報 68(1), 35-47, 2019
… <p>Stem cells are promising cell source for treatment of multiple diseases as well as myocardial infarction. … Rabbit model has essentially used for cardiovascular diseases and regeneration but information on establishment of induced pluripotent stem cells (iPSCs) and differentiation potential is fairly limited. …
NAID 130007604454

重症心不全に対する細胞シートを用いた心筋再生治療 (第5土曜特集心不全のすべて : 分子生物学から緩和ケアまで : beyondガイドライン) -- (心不全のトピックス)

宮川繁
医学のあゆみ 266(13), 1239-1242, 2018-09-29
NAID 40021672326

ここまで知っておきたい心筋症：小児心筋症における再生医療の展望

小垣滋豊
日本小児循環器学会雑誌 34(3), 121-127, 2018
<p>小児心筋症は稀少疾患でありその予後は必ずしも良好ではない．重症例では補助人工心臓や移植が治療の選択肢となるが，合併症やドナー不足のためにその適応は限られたものとなる．心臓再生医療は，難治性心筋疾患に対するアンメットメディカルニーズとして期待が高まっており，最近のトランスレーショナルリサーチにより，成人患者の心筋障害に対する心機能改善や左室リモデリング抑制が実現化し，骨髄由来細胞， …
NAID 130007550227