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Interplay between cytoskeletal polymerization and the chondrogenic phenotype in chondrocytes passaged in monolayer culture.

Parreno J1,2,3, Nabavi Niaki M1,2,4, Andrejevic K1,2,3, Jiang A1,2, Wu PH1,2, Kandel RA5,6,7,8,9.
Journal of anatomy.J Anat.2016 Nov 3. doi: 10.1111/joa.12554. [Epub ahead of print]
Tubulin and actin exist as monomeric units that polymerize to form either microtubules or filamentous actin. As the polymerization status (monomeric/polymeric ratio) of tubulin and/or actin have been shown to be important in regulating gene expression and phenotype in non-chondrocyte cells, the obje
PMID 27807861

Comparison of ex vivo harvested and in vitro cultured materials from Echinococcus granulosus by measuring expression levels of five genes putatively involved in the development and maturation of adult worms.

Dezaki ES1,2, Yaghoubi MM3, Spiliotis M2, Boubaker G2, Taheri E4, Almani PG1, Tohidi F1, Harandi MF5, Gottstein B6.
Parasitology research.Parasitol Res.2016 Nov;115(11):4405-4416. Epub 2016 Aug 12.
Parts of the natural life cycle of Echinococcus granulosus can be retraced in vitro such as the development of protoscoleces into semiadult worms with three or more proglottids, or the redifferentiation of in vitro cultured protoscoleces into metacestode-like cystic structures. Most in vitro generat
PMID 27515372

Endogenous DKK1 and FRZB regulate chondrogenesis and hypertrophy in 3D cultures of human chondrocytes and human mesenchymal stem cells.

Zhong L, Huang X, Rodrigues ED, Leijten J1, Verrips T, Khattabi ME, Karperien M, Post JN2.
Stem cells and development.Stem Cells Dev.2016 Oct 12. [Epub ahead of print]
Hypertrophic differentiation occurs during in vitro chondrogenesis of mesenchymal stem cells (MSCs), decreasing the quality of the cartilage construct. Previously we identified WNT pathway antagonists Dickkopf 1 homolog (DKK1) and frizzled-related protein (FRZB) as key factors in blocking hypertroph
PMID 27733096

Comprehension of terminal differentiation and dedifferentiation of chondrocytes during passage cultures(CELL AND TISSUE ENGINEERING)

Nadzir Masrina Mohd,Kino-oka Masahiro,Maruyama Nao,Sato Yasuaki,Kim Mee-Hae,Sugawara Katsura,Taya Masahito
Journal of bioscience and bioengineering 112(4), 395-401, 2011-10
… When the chondrocytes passaged up to the middle age were embedded in collagen gel, the high frequency of single hypertrophic cells with collagen type II formation was recognized, which supports the thought that the high gene expression of collagen type II was attributed to terminal differentiation rather than redifferentiation. …
NAID 110008761498

Quantitative correlation between production rate of melanoma inhibitory activity and aggrecan gene expression level during differentiation from mesenchymal stem cells to chondrocytes and redifferentiation of chondrocytes(CELL AND TISSUE ENGINEERING)

Onoue Kaori,Kusubashi Hideki,Sato Yasushi,Wakitani Shigeyuki,Takagi Mutsumi
Journal of bioscience and bioengineering 111(5), 594-596, 2011-05
… The cell-specific production rate of melanoma inhibitory activity was quantitatively proportional to the aggrecan gene expression level in the early and middle phase during not only the redifferentiation culture of human cartilage chondrocytes but also the differentiation culture of human bone marrow mesenchymal stem cells to chondrocytes. …
NAID 110008661210