bridge

• n.

• 橋、(歯科)義歯、ブリッジ

　 　 　 　 　 　 　 　 　 　 　 　 　 　

WordNet

1. something resembling a bridge in form or function; "his letters provided a bridge across the centuries"
2. make a bridge across; "bridge a river"
3. a circuit consisting of two branches (4 arms arranged in a diamond configuration) across which a meter is connected (同)bridge circuit
4. an upper deck where a ship is steered and the captain stands (同)bridge deck
5. a denture anchored to teeth on either side of missing teeth (同)bridgework
6. the link between two lenses; rests on the nose (同)nosepiece
7. a structure that allows people or vehicles to cross an obstacle such as a river or canal or railway etc. (同)span
8. a wooden support that holds the strings up
9. any of various card games based on whist for four players
10. the hard ridge that forms the upper part of the nose; "her glasses left marks on the bridge of her nose"
11. connect or reduce the distance between (同)bridge over
12. cross over on a bridge
13. a bridge that can be raised to block passage or to allow boats or ships to pass beneath it (同)lift bridge
14. a bridge designed for pedestrians (同)overcrossing, pedestrian bridge
15. a dictionary that has not been shortened by the omitting terms or definitions; a comprehensive dictionary (同)unabridged
16. bridge constructed of two cantilevers that meet in the middle

PrepTutorEJDIC

1. 橋 / 船橋,艦橋 / 鼻柱 / (めがねの)ブリッジ(2つのレンズを接続し鼻の上にのせる部分) / (弦楽器の)こま / ブリッジ(隣接する歯に両端を固定した義歯) / 〈川・道路・線路など〉‘に'橋渡しをする,‘を'連結する
2. (カードゲームの)ブリッジ
3. (船を通過させる)はね橋;(城の)釣り上げ橋
4. 歩道橋
5. オークションブリッジ(カードゲームの一種)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/15 22:58:03」(JST)

wiki ja

[Wiki ja表示]

ブリッジ、ブリッヂ (bridge)

語句・専門用語

• 英語で橋・橋梁のこと。
• 船橋のこと。
• ブリッジ (運動) - 仰向け状態で両足と両手や頭部のみを床に付け、背中を橋状に反らせ、その状態を維持するストレッチ運動、技術。レスリングでの攻防や、プロレスの投げ技などでも使用される。
• ブリッジ (お笑い用語) - お笑い用語で、ショートコントなどの連続したネタの間にはさむ言葉や動作のこと。
• 音楽用語で、楽曲のAメロ（Bメロ）とサビをつなげる部分。またはBメロのこと。
• 映画やドラマ、舞台演劇などで流れる伴奏音楽（劇伴）の中で、場面転換時などに使用される短い楽曲。

道具・装置・物

• ブリッジ (歯科) - 歯科において用いる補綴物の一種。
• ブリッジ (ネットワーク機器) - コンピュータネットワークにおいて用いられる装置の一つ。あるいはブリッジ接続のこと。
• ブリッジ (高速戦闘支援艦) - アメリカ海軍の高速戦闘支援艦。
• ブリッジ回路 - 古くは電橋ともいった。整流器に用いるダイオードの接続方式など。
• ギターやバイオリンなどの弦楽器で弦を支える駒。
• 眼鏡の部品の一つで、鼻の前にある、両方のレンズを繋ぐもの。眼鏡#眼鏡の構成を参照。

トランプゲーム

• トランプゲームの一種、コントラクトブリッジの通称。
• セブンブリッジ - トランプゲームの一種。

英語圏の姓

• ウェイン・ブリッジ - イングランドのサッカー選手。
• フランク・ブリッジ - イギリスの作曲家。
• マーク・ブリッジ - オーストラリアのサッカー選手。

組織・団体

• ブリッジ (バンド) - 日本の音楽バンド。かつて清水ひろたかやカジヒデキが在籍していた。
• ブリッジ (テレビ制作会社) - テレビ番組の制作プロダクション会社。
• ブリッジ (アニメ制作会社) - 日本のアニメ制作会社。旧サンライズ第6スタジオ。
• ブリッジ (ゲーム会社) - 日本のゲーム開発企業。
• ブリッジテントレーベル - ラビリンスと香澄の所属するレーベル。

作品名

• ブリッジ (映画) - 2006年に製作されたアメリカ映画（監督はエリック・スティール）。原題は『The Bridge』。
• THE BRIDGE/ブリッジ - 2011年に製作されたスウェーデン＝デンマーク合作のTVドラマシリーズ。原題は『Bron/Broen』。

音楽作品

• ザ・ブリッジ - ビリー・ジョエルのアルバム。
• BRIDGE (HOUND DOGのアルバム) - HOUND DOGのアルバム。
• BRIDGE〜あの橋をわたるとき〜 - HOUND DOGのシングル曲。上記のアルバムにも収録。
• BRIDGE (SPEEDのアルバム) - SPEEDのアルバム。
• Bridge (玉木宏のアルバム) - 玉木宏のアルバム。
• Bridge (米倉千尋の曲) - 米倉千尋のシングル曲。プレイステーション2ゲーム「学園都市ヴァラノワール」オープニング主題歌。
• BRIDGE (ゴスペラーズの曲) - ゴスペラーズのシングル曲。
• Bridge (fox capture planのアルバム) - fox capture planのアルバム。

メディア関連

• bridge (雑誌) - ロッキング・オン社の雑誌。
• Adobe Bridge - アドビシステムズが販売する、全アプリケーションをナビゲートし、連動させるためのパソコン用ソフトウェア。

綴りが異なるもの

• ブリッジ (ゲーム会社) (vridge) - 日本のゲーム開発会社。

関連項目

• ブリッジで始まる記事の一覧
• Bridgeで始まる記事の一覧

脚注

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wiki en

[Wiki en表示]

This article is about the structure. For the card game, see Contract bridge. For other uses, see Bridge (disambiguation) and Bridges (disambiguation).

The Akashi Kaikyō Bridge in Japan, currently the world's longest suspension span.

The Siosepol bridge over Zayandeh River is an example of Safavid dynasty (1502–1722) bridge design. Esfahan, Iran

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A bridge is a structure built to span physical obstacles without closing the way underneath such as a body of water, valley, or road, for the purpose of providing passage over the obstacle. There are many different designs that each serve a particular purpose and apply to different situations. Designs of bridges vary depending on the function of the bridge, the nature of the terrain where the bridge is constructed and anchored, the material used to make it, and the funds available to build it.

Etymology

The Oxford English Dictionary traces the origin of the word bridge to an Old English word brycg, of the same meaning. The word can be traced directly back to Proto-Indo-European *bʰrēw-. The word for the card game of the same name has a different origin.

History

The first bridges made by humans were probably spans of cut wooden logs or planks and eventually stones, using a simple support and crossbeam arrangement. Some early Americans used trees or bamboo poles to cross small caverns or wells to get from one place to another. A common form of lashing sticks, logs, and deciduous branches together involved the use of long reeds or other harvested fibers woven together to form a huge rope capable of binding and holding together the materials used in early bridges.

The Arkadiko Bridge in Greece (13th century BC), one of the oldest arch bridges in existence

The Arkadiko Bridge is one of four Mycenaean corbel arch bridges part of a former network of roads, designed to accommodate chariots, between Tiryns and Epidauros in the Peloponnese, in Greece. Dating to the Greek Bronze Age (13th century BC), it is one of the oldest arch bridges still in existence and use. Several intact arched stone bridges from the Hellenistic era can be found in the Peloponnese in southern Greece

The greatest bridge builders of antiquity were the ancient Romans. The Romans built arch bridges and aqueducts that could stand in conditions that would damage or destroy earlier designs. Some stand today. An example is the Alcántara Bridge, built over the river Tagus, in Spain. The Romans also used cement, which reduced the variation of strength found in natural stone. One type of cement, called pozzolana, consisted of water, lime, sand, and volcanic rock. Brick and mortar bridges were built after the Roman era, as the technology for cement was lost then later rediscovered.

The Arthashastra of Kautilya mentions the construction of dams and bridges. A Mauryan bridge near Girnar was surveyed by James Princep. The bridge was swept away during a flood, and later repaired by Puspagupta, the chief architect of emperor Chandragupta I. The bridge also fell under the care of the Yavana Tushaspa, and the Satrap Rudra Daman. The use of stronger bridges using plaited bamboo and iron chain was visible in India by about the 4th century. A number of bridges, both for military and commercial purposes, were constructed by the Mughal administration in India.

Although large Chinese bridges of wooden construction existed at the time of the Warring States, the oldest surviving stone bridge in China is the Zhaozhou Bridge, built from 595 to 605 AD during the Sui Dynasty. This bridge is also historically significant as it is the world's oldest open-spandrel stone segmental arch bridge. European segmental arch bridges date back to at least the Alconétar Bridge (approximately 2nd century AD), while the enormous Roman era Trajan's Bridge (105 AD) featured open-spandrel segmental arches in wooden construction.

Rope bridges, a simple type of suspension bridge, were used by the Inca civilization in the Andes mountains of South America, just prior to European colonization in the 16th century.

During the 18th century there were many innovations in the design of timber bridges by Hans Ulrich, Johannes Grubenmann, and others. The first book on bridge engineering was written by Hubert Gautier in 1716. A major breakthrough in bridge technology came with the erection of the Iron Bridge in Coalbrookdale, England in 1779. It used cast iron for the first time as arches to cross the river Severn.

With the Industrial Revolution in the 19th century, truss systems of wrought iron were developed for larger bridges, but iron did not have the tensile strength to support large loads. With the advent of steel, which has a high tensile strength, much larger bridges were built, many using the ideas of Gustave Eiffel.

In 1927 welding pioneer Stefan Bryła designed the first welded road bridge in the world, the Maurzyce Bridge which was later built across the river Słudwia at Maurzyce near Łowicz, Poland in 1929. In 1995, the American Welding Society presented the Historic Welded Structure Award for the bridge to Poland.

Types of bridges

Bridges can be categorized in several different ways. Common categories include the type of structural elements used, by what they carry, whether they are fixed or movable, and by the materials used.

Structure type

Bridges may be classified by how the forces of tension, compression, bending, torsion and shear are distributed through their structure. Most bridges will employ all of the principal forces to some degree, but only a few will predominate. The separation of forces may be quite clear. In a suspension or cable-stayed span, the elements in tension are distinct in shape and placement. In other cases the forces may be distributed among a large number of members, as in a truss, or not clearly discernible to a casual observer as in a box beam.

Beam bridge	Beam bridges are horizontal beams supported at each end by substructure units and can be either simply supported when the beams only connect across a single span, or continuous when the beams are connected across two or more spans. When there are multiple spans, the intermediate supports are known as piers. The earliest beam bridges were simple logs that sat across streams and similar simple structures. In modern times, beam bridges can range from small, wooden beams to large, steel boxes. The vertical force on the bridge becomes a shear and flexural load on the beam which is transferred down its length to the substructures on either side They are typically made of steel, concrete or wood. Beam bridge spans rarely exceed 250 feet (76 m) long, as the flexural stresses increase proportional to the square of the length (and deflection increases proportional to the 4th power of the length). However, the main span of the Rio-Niteroi Bridge, a box girder bridge, is 300 metres (980 ft). The world's longest beam bridge is Lake Pontchartrain Causeway in southern Louisiana in the United States, at 23.83 miles (38.35 km), with individual spans of 56 feet (17 m). Beam bridges are the most common bridge type in use today.
Truss bridge	A truss bridge is a bridge whose load-bearing superstructure is composed of a truss. This truss is a structure of connected elements forming triangular units. The connected elements (typically straight) may be stressed from tension, compression, or sometimes both in response to dynamic loads. Truss bridges are one of the oldest types of modern bridges. The basic types of truss bridges shown in this article have simple designs which could be easily analyzed by nineteenth and early twentieth century engineers. A truss bridge is economical to construct owing to its efficient use of materials.
Cantilever bridge	Cantilever bridges are built using cantilevers—horizontal beams supported on only one end. Most cantilever bridges use a pair of continuous spans that extend from opposite sides of the supporting piers to meet at the center of the obstacle the bridge crosses. Cantilever bridges are constructed using much the same materials & techniques as beam bridges. The difference comes in the action of the forces through the bridge. Some cantilever bridges also have a smaller beam connecting the two cantilevers, for extra strength. The largest cantilever bridge is the 549-metre (1,801 ft) Quebec Bridge in Quebec, Canada.
Arch bridge	Arch bridges have abutments at each end. The weight of the bridge is thrust into the abutments at either side. The earliest known arch bridges were built by the Greeks, and include the Arkadiko Bridge. With the span of 220 metres (720 ft), the Solkan Bridge over the Soča River at Solkan in Slovenia is the second largest stone bridge in the world and the longest railroad stone bridge. It was completed in 1905. Its arch, which was constructed from over 5,000 tonnes (4,900 long tons; 5,500 short tons) of stone blocks in just 18 days, is the second largest stone arch in the world, surpassed only by the Friedensbrücke (Syratalviadukt) in Plauen, and the largest railroad stone arch. The arch of the Friedensbrücke, which was built in the same year, has the span of 90 m (295 ft) and crosses the valley of the Syrabach River. The difference between the two is that the Solkan Bridge was built from stone blocks, whereas the Friedensbrücke was built from a mixture of crushed stone and cement mortar. The world's current largest arch bridge is the Chaotianmen Bridge over the Yangtze River with a length of 1,741 m (5,712 ft) and a span of 552 m (1,811 ft). The bridge was opened April 29, 2009 in Chongqing, China.
Tied arch bridge	Tied arch bridges have an arch-shaped superstructure, but differ from conventional arch bridges. Instead of transferring the weight of the bridge and traffic loads into thrust forces into the abutments, the ends of the arches are restrained by tension in the bottom chord of the structure. They are also called bowstring arches.
Suspension bridge	Suspension bridges are suspended from cables. The earliest suspension bridges were made of ropes or vines covered with pieces of bamboo. In modern bridges, the cables hang from towers that are attached to caissons or cofferdams. The caissons or cofferdams are implanted deep into the floor of a lake or river. Sub-types include the simple suspension bridge, the stressed ribbon bridge, the underspanned suspension bridge, the suspended-deck suspension bridge, and the self-anchored suspension bridge. The longest suspension bridge in the world is the 3,909 m (12,825 ft) Akashi Kaikyō Bridge in Japan.
Cable-stayed bridge	Cable-stayed bridges, like suspension bridges, are held up by cables. However, in a cable-stayed bridge, less cable is required and the towers holding the cables are proportionately higher. The first known cable-stayed bridge was designed in 1784 by C. T. (or C. J.) Löscher. The longest cable-stayed bridge since 2012 is the Russky Bridge in Vladivostok, Russia.

Fixed or movable bridges

Play media

Moving a Bloomingdale Trail bridge from Ashland to Western in Chicago.

Most bridges are fixed bridges, meaning they have no moving parts and stay in one place until they fail or are demolished. Temporary bridges, such as Bailey bridges, are designed to be assembled, and taken apart, transported to a different site, and re-used. They are important in military engineering, and are also used to carry traffic while an old bridge is being rebuilt. Movable bridges are designed to move out of the way of boats or other kinds of traffic, which would otherwise be too tall to fit. These are generally electrically powered.

Double-decked bridges

The double-decked George Washington Bridge, connecting New York City to Bergen County, New Jersey, USA, is the world's busiest bridge, carrying 102 million vehicles annually.

See also: List of multi-level bridges

Double-decked (or double-decker) bridges have two levels, such as the George Washington Bridge, connecting New York City to Bergen County, New Jersey, USA, as the world's busiest bridge, carrying 102 million vehicles annually; truss work between the roadway levels provided stiffness to the roadways and reduced movement of the upper level when the lower level was installed three decades following the upper level. The Tsing Ma Bridge and Kap Shui Mun Bridge in Hong Kong have six lanes on their upper decks, and on their lower decks there are two lanes and a pair of tracks for MTR metro trains. Some double-decked bridges only use one level for street traffic; the Washington Avenue Bridge in Minneapolis reserves its lower level for automobile and light rail traffic and its upper level for pedestrian and bicycle traffic (predominantly students at the University of Minnesota). Likewise, in Toronto, the Prince Edward Viaduct has five lanes of motor traffic, bicycle lanes, and sidewalks on its upper deck; and a pair of tracks for the Bloor–Danforth subway line on its lower deck. The western span of the San Francisco–Oakland Bay Bridge also has two levels.

Robert Stephenson's High Level Bridge across the River Tyne in Newcastle upon Tyne, completed in 1849, is an early example of a double-decked bridge. The upper level carries a railway, and the lower level is used for road traffic. Other examples include Britannia Bridge over the Menai Strait and Craigavon Bridge in Derry, Northern Ireland. The Oresund Bridge between Copenhagen and Malmö consists of a four-lane highway on the upper level and a pair of railway tracks at the lower level. Tower Bridge in London is different example of a double-decked bridge, with the central section consisting of a low level bascule span and a high level footbridge.

Viaducts

Main article: Viaduct

A viaduct is made up of multiple bridges connected into one longer structure. The longest and some of the highest bridges are viaducts, such as the Lake Pontchartrain Causeway and Millau Viaduct.

Three-way bridges

The three-way Tridge

Main article: Three-way bridge

A three-way bridge has three separate spans which meet near the center of the bridge. The bridge appears as a "T" or "Y" when viewed from above. Three-way bridges are extremely rare. The Tridge, Margaret Bridge, and Zanesville Y-Bridge are examples.

Bridge types by use

The railway bridge over Mura River in Mursko Središće, Croatia

A bridge can be categorized by what it is designed to carry, such as trains, pedestrian or road traffic, a pipeline or waterway for water transport or barge traffic. An aqueduct is a bridge that carries water, resembling a viaduct, which is a bridge that connects points of equal height. A road-rail bridge carries both road and rail traffic. A bridge can carry overhead power lines as does the Storstrøm Bridge.

Some bridges accommodate other purposes, such as the tower of Nový Most Bridge in Bratislava, which features a restaurant, or a bridge-restaurant which is a bridge built to serve as a restaurant. Other suspension bridge towers carry transmission antennas.

Bridges are subject to unplanned uses as well. The areas underneath some bridges have become makeshift shelters and homes to homeless people, and the undersides of bridges all around the world are spots of prevalent graffiti. Some bridges attract people attempting suicide, and become known as suicide bridges.

Bridge types by material

The Iron Bridge completed in 1781 was the first cast iron bridge.

Okazaki Bridge, Japan, painted by Hiroshige 1833/1834

The materials used to build the structure are also used to categorize bridges. Until the end of the 18th Century, bridges were made out of timber, stone and masonry. Modern bridges are currently built in concrete, steel, fiber reinforced polymers (FRP), stainless steel or combinations of those materials. Living bridges have been constructed of live plants such as tree roots in India and vines in Japan.

Bridge Type	Materials Used
Cantilever	For small footbridges, the cantilevers may be simple beams; however, large cantilever bridges designed to handle road or rail traffic use trusses built from structural steel, or box girders built from prestressed concrete.
Suspension	The cables are usually made of steel cables coated with Zinc, along with most of the bridge, but some bridges are still made with steel reinforced concrete.
Arch	Stone, brick and other such materials that are strong in compression and somewhat so in shear.
Beam	Beam bridges can use pre-stressed concrete, an inexpensive building material, which is then embedded with rebar. The resulting bridge can resist both compression and tension forces.
Truss	The triangular pieces of Truss bridges are manufactured from straight and steel bars, according to the truss bridge designs.

Aesthetics

Most bridges are utilitarian in appearance, but in some cases, the appearance of the bridge can have great importance. Often, this is the case with a large bridge that serves as an entrance to a city, or crosses over a main harbor entrance. These are sometimes known as signature bridges. Designers of bridges in parks and along parkways often place more importance to aesthetics, as well. Examples include the stone-faced bridges along the Taconic State Parkway in New York.

To create a beautiful image, some bridges are built much taller than necessary. This type, often found in east-Asian style gardens, is called a Moon bridge, evoking a rising full moon. Other garden bridges may cross only a dry bed of stream washed pebbles, intended only to convey an impression of a stream. Often in palaces a bridge will be built over an artificial waterway as symbolic of a passage to an important place or state of mind. A set of five bridges cross a sinuous waterway in an important courtyard of the Forbidden City in Beijing, China. The central bridge was reserved exclusively for the use of the Emperor, Empress, and their attendants.

Bridge maintenance

Bridge maintenance consisting of a combination of structural health monitoring and testing. This is regulated in country-specific engineer standards and includes e.g. an ongoing monitoring every three to six months, a simple test or inspection every two to three years and a major inspection every six to ten years. In Europe, the cost of maintenance is higher than spending on new bridges. The lifetime of welded steel bridges can be significantly extended by aftertreatment of the weld transitions . This results in a potential high benefit, using existing bridges far beyond the planned lifetime.

Highway bridge with steel hollow box sections, performed for lifetime extension by welding aftertreatment

Bridge failures

See also: List of bridge failures

The failure of bridges is of special concern for structural engineers in trying to learn lessons vital to bridge design, construction and maintenance. The failure of bridges first assumed national interest during the Victorian era when many new designs were being built, often using new materials.

In the United States, the National Bridge Inventory tracks the structural evaluations of all bridges, including designations such as "structurally deficient" and "functionally obsolete".

Bridge monitoring

There are several methods used to monitor the stress on large structures like bridges. The most common method is the use of an accelerometer, which is integrated into the bridge while it is being built. This technology is used for long-term surveillance of the bridge.

Another option for structural-integrity monitoring is "non-contact monitoring", which uses the Doppler effect (Doppler shift). A laser beam from a Laser Doppler Vibrometer is directed at the point of interest, and the vibration amplitude and frequency are extracted from the Doppler shift of the laser beam frequency due to the motion of the surface. The advantage of this method is that the setup time for the equipment is faster and, unlike an accelerometer, this makes measurements possible on multiple structures in as short a time as possible. Additionally, this method can measure specific points on a bridge that might be difficult to access.

Visual index

Further information: List of bridge types and List of longest bridges in the world

See also

• Architectural engineering
• Bridge to nowhere
• Bridges Act
• BS 5400, a British Standard for steel, concrete and composite bridges
• BT Centre for Major Programme Management
• Cost overrun in bridge construction
• Cross-sea traffic ways
• Culvert
• Deck
• Footbridge
• Landscape architecture
• Megaproject
• Overpass
• Transporter bridge
• Tensegrity
• Tunnel

References

Further reading

• Brown, David J. Bridges: Three Thousand Years of Defying Nature. Richmond Hill, Ont: Firefly Books, 2005. ISBN 1-55407-099-6.
• Sandak, Cass R. Bridges. An Easy-read modern wonders book. New York: F. Watts, 1983. ISBN 0-531-04624-9.
• Whitney, Charles S. Bridges of the World: Their Design and Construction. Mineola, NY: Dover Publications, 2003. ISBN 0-486-42995-4 (Unabridged republication of Bridges : a study in their art, science, and evolution. 1929.)
• Kinney, A. R.; el al. (2003). Worshiping Siva and Buddha: The Temple Art of East Java. University of Hawaii Press. ISBN 0-8248-2779-1.
• Buck, William; el al. (2000). Ramayana. University of California Press. ISBN 0-520-22703-4.

External links

• Digital Bridge: Bridges of the Nineteenth Century, a collection of digitized books at Lehigh University
• Structurae – International Database and Gallery of Engineerings Structures with over 10000 Bridges.
• U.S. Federal Highway Administration Bridge Technology
• The Museum of Japanese Timber Bridges Fukuoka University
• "bridge-info.org": site for bridges
• [1] (CNN) 24 of the World's Most Amazing Bridges -retrieved April 30, 2011

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English Journal

• Digital multimeter-based immunosensing strategy for sensitive monitoring of biomarker by coupling an external capacitor with an enzymatic catalysis.

• Tang D1, Zhang B2, Liu B2, Chen G2, Lu M3.Author information 1Key Laboratory of Analysis and Detection for Food Safety (Ministry of Education & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108, PR China. Electronic address: dianping.tang@fzu.edu.cn.2Key Laboratory of Analysis and Detection for Food Safety (Ministry of Education & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108, PR China.3Institute of Environmental and Analytical Science, School of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan, PR China. Electronic address: minghua.lu2009@hotmail.com.AbstractA new digital multimeter (DMM)-based immunosensing system was designed for quantitative monitoring of biomarker (prostate-specific antigen, PSA used in this case) by coupling with an external capacitor and an enzymatic catalytic reaction. The system consisted of a salt bridge-linked reaction cell and a capacitor/DMM-joined electronic circuit. A sandwich-type immunoreaction with target PSA between the immobilized primary antibody and glucose oxidase (GOx)-labeled detection antibody was initially carried out in one of the two half-cells. Accompanying the sandwiched immunocomplex, the conjugated GOx could catalyze the oxidation of glucose, simultaneously resulting in the conversion of [Fe(CN)6](3-) to [Fe(CN)6](4-). The difference in the concentrations of [Fe(CN)6](3-)/[Fe(CN)6](4-) in two half-cells automatically produced a voltage that was utilized to charge an external capacitor. With the closing circuit switch, the capacitor discharged through the DMM, which could provide a high instantaneous current. Under the optimal conditions, the resulting currents was indirectly proportional to the concentration of target PSA in the dynamic range of 0.05-7ngmL(-1) with a detection limit (LOD) of 6pgmL(-1). The reproducibility, precision, and selectivity were acceptable. In addition, the methodology was validated by analyzing 12 clinical serum specimens, receiving a good accordance with the referenced values for the detection of PSA.
• Biosensors & bioelectronics.Biosens Bioelectron.2014 May 15;55:255-8. doi: 10.1016/j.bios.2013.12.022. Epub 2013 Dec 16.
• A new digital multimeter (DMM)-based immunosensing system was designed for quantitative monitoring of biomarker (prostate-specific antigen, PSA used in this case) by coupling with an external capacitor and an enzymatic catalytic reaction. The system consisted of a salt bridge-linked reaction cell an
• PMID 24389061

• Expression of tapasin in rainbow trout tissues and cell lines and up regulation in a monocyte/macrophage cell line (RTS11) by a viral mimic and viral infection.

• Sever L1, Vo NT1, Bols NC1, Dixon B2.Author information 1Department of Biology, University of Waterloo, 200 University Ave W., Waterloo, Ontario N2L 3G1, Canada.2Department of Biology, University of Waterloo, 200 University Ave W., Waterloo, Ontario N2L 3G1, Canada. Electronic address: bdixon@uwaterloo.ca.AbstractTapasin is a transmembrane glycoprotein that acts as a bridge between the transporter associated with antigen processing and the MHC class I receptor in mammals. Through the development of antibody against trout tapasin, this report demonstrates the detection of trout tapasin as a N-glycosylated 48kDa protein. Tissue and cell line distribution revealed that tapasin protein is expressed mainly in immune system organs and in rainbow trout epithelial cell lines from gill (RTgill-W1), liver (RTL-W1), and intestine (RTgutGC). An additional 20kDa band was observed in tissues and cell lines, and appeared to be most prominent in RTgutGC but was absent in peripheral blood leukocytes. Tapasin 48kDa protein was most strongly expressed in RTS11 (monocyte/macrophage cell line) and its regulation following dsRNA stimulation was explored. Upon poly I:C treatment and Chum Salmon Reovirus (CSV) infection, tapasin protein expression was upregulated up to 3.5 fold and 3 fold respectively, in parallel with increased expression of the glycosylated MH class I heavy chain, whereas the expression of the 20kDa form remained unchanged. Overall this work demonstrates the induction of tapasin protein by dsRNA stimulation, which implies its possible conserved regulation during viral infection in teleost cells.
• Developmental and comparative immunology.Dev Comp Immunol.2014 May;44(1):86-93. doi: 10.1016/j.dci.2013.11.019. Epub 2013 Dec 7.
• Tapasin is a transmembrane glycoprotein that acts as a bridge between the transporter associated with antigen processing and the MHC class I receptor in mammals. Through the development of antibody against trout tapasin, this report demonstrates the detection of trout tapasin as a N-glycosylated 48k
• PMID 24321527

• The behavior of neuronal cells on tendon-derived collagen sheets as potential substrates for nerve regeneration.

• Alberti KA1, Hopkins AM2, Tang-Schomer MD3, Kaplan DL4, Xu Q5.Author information 1Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address: kyle.alberti@tufts.edu.2Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address: amy.hopkins@Tufts.edu.3Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address: min.tang-schomer@tufts.edu.4Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.5Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address: qiaobing.xu@tufts.edu.AbstractPeripheral nervous system injuries result in a decreased quality of life, and generally require surgical intervention for repair. Currently, the gold standard of nerve autografting, based on the use of host tissue such as sensory nerves is suboptimal as it results in donor-site loss of function and requires a secondary surgery. Nerve guidance conduits fabricated from natural polymers such as collagen are a common alternative to bridge nerve defects. In the present work, tendon sections derived through a process named bioskiving were studied for their potential for use as a substrate to fabricate nerve guidance conduits. We show that cells such as rat Schwann cells adhere, proliferate, and align along the fibrous tendon substrate which has been shown to result in a more mature phenotype. Additionally we demonstrate that chick dorsal root ganglia explants cultured on the tendon grow to similar lengths compared to dorsal root ganglia cultured on collagen gels, but also grow in a more oriented manner on the tendon sections. These results show that tendon sections produced through bioskiving can support directional nerve growth and may be of use as a substrate for the fabrication of nerve guidance conduits.
• Biomaterials.Biomaterials.2014 Apr;35(11):3551-7. doi: 10.1016/j.biomaterials.2013.12.082. Epub 2014 Jan 22.
• Peripheral nervous system injuries result in a decreased quality of life, and generally require surgical intervention for repair. Currently, the gold standard of nerve autografting, based on the use of host tissue such as sensory nerves is suboptimal as it results in donor-site loss of function and
• PMID 24461939

• Genistein Induces Cytokinesis Failure Through RhoA Delocalization and Anaphase Chromosome Bridging.

• Nakayama Y, Saito Y, Soeda S, Iwamoto E, Ogawa S, Yamagishi N, Kuga T, Yamaguchi N.Author information Department of Biochemistry and Molecular Biology, Kyoto Pharmaceutical University, Kyoto, 607-8414, Japan; Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.AbstractGenistein, an isoflavone abundantly present in soybeans, possesses anticancer properties and induces growth inhibition including cell cycle arrest and apoptosis. Although abnormal cell division, such as defects in chromosome segregation and spindle formation, and polyploidization have been described, the mechanisms underlying the induction of abnormal cell division are unknown. In this study, we examined the effect of genistein on cell division in cells that are synchronized in M phase, since genistein treatment delays mitotic entry in asynchronous cells. HeLa S3 cells were arrested at the G2 phase and subsequently released into the M phase in presence of genistein. Immunofluorescence staining showed that genistein treatment delays M phase progression. Time-lapse analysis revealed that the delay occurs until anaphase onset. In addition, genistein treatment induces cleavage furrow regression, resulting in the generation of binucleated cells. Central spindle formation, which is essential for cytokinesis, is partially disrupted in genistein-treated cells. Moreover, aberrant chromosome segregation, such as a chromosome bridge and lagging chromosome, occurs through progression of cytokinesis. RhoA, which plays a role in the assembly and constriction of an actomyosin contractile ring, is delocalized from the cortex of the ingressing cleavage furrow. These results suggest that genistein treatment induces binucleated cell formation through cleavage furrow regression, which is accompanied by chromosome bridge formation and RhoA delocalization. Our results provide the mechanism that underlies genistein-induced polyploidization, which may be involved in genistein-induced growth inhibition. J. Cell. Biochem. 115: 763-771, 2014. © 2013 Wiley Periodicals, Inc.
• Journal of cellular biochemistry.J Cell Biochem.2014 Apr;115(4):763-71. doi: 10.1002/jcb.24720.
• Genistein, an isoflavone abundantly present in soybeans, possesses anticancer properties and induces growth inhibition including cell cycle arrest and apoptosis. Although abnormal cell division, such as defects in chromosome segregation and spindle formation, and polyploidization have been described
• PMID 24453048

Japanese Journal

• 実時間実空間密度汎関数理論による電子動力学シミュレーションのXeon Phiクラスタ向け最適化

• 廣川 祐太,朴 泰祐,佐藤 駿丞,矢花 一浩
• 情報処理学会研究報告. [ハイパフォーマンスコンピューティング] 2015-HPC-148(19), 1-8, 2015-02-23
• … simulator) を Xeon Phi クラスタへポーティングし,最適化と性能評価を行った.まず,ステンシル計算カーネルに対しベクトル化や最適化オプションの付与,OpenMP の実行環境などの最適化を行い,Intel E5-2670v2 (Ivy-Bridge,10 コア) と同等の性能を得られた.時間発展部全体では,CPU と Xeon Phi 間で協調計算を行う Symmetric 実行により,CPU のみを利用する場合に比べて 32 ノード時に約 1.68 倍の性能が得られた.プロセス数で比較すると,S …
• NAID 110009877728

• 視線情報を用いたユーザ所望画像の識別に対するスパースコーディングの適用に関する検討

• 西口 侑希,菅沼 睦,亀山 渉
• 情報処理学会研究報告. [オーディオビジュアル複合情報処理] 2015-AVM-88(1), 1-6, 2015-02-20
• 近年,ディジタル画像の増加に伴って画像検索技術の発展が期待されている.セマンティックギャップの解消に向けて,ユーザのフィードバックから学習を行い,出力結果をユーザが求める結果に近づけていく適合性フィードバックが注目されている.視線を用いたフィードバックが可能になれば,ユーザは画像を閲覧するだけでフィードバックを返すことができるだけでなく,ユーザ自身が意識しなかったような画像もフィードバックに用いる …
• NAID 110009877747

• (独)土木研究所 構造物メンテナンス研究センター CAESAR臨床研究事例(最終回)植苗(うえなえ)橋 : ポステンPC桁のグラウト充填状況調査

• 石田 雅博,廣江 亜紀子
• 橋梁と基礎 49(2), 73-76, 2015-02
• NAID 40020352389

• 橋の点検に行こう! : 初心者のための橋梁点検講座(第2回)鋼橋の損傷と点検のポイント

• 小西 拓洋
• 橋梁と基礎 49(2), 67-72, 2015-02
• NAID 40020352380

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