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- Component analysis of Pu-erh and its anti-constipation effects.
- Li G, Wang Q, Qian Y, Zhou Y, Wang R, Zhao X.Author information Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, P.R. China.AbstractThe aim of this study was to investigate the effects of Pu-erh tea on activated carbon-induced constipation in ICR mice. The changes in body weight, dietary intake, gastrointestinal transit, first black stool defecation time, number and weight of feces, water content of feces and various levels of substances in serum were used to evaluate the anti-constipation effects of Pu-erh tea. Body weight, dietary intake and the amount of water consumed by mice decreased with activated carbon-induced constipation and those of the sample treated group mice were higher than the control group mice. The first black stool time of normal, control, bisacodyl (100 mg/kg) and 200, 400 and 800 mg/kg Pu-erh tea treated mice were 90, 221, 118, 178, 155 and 139 min, respectively. Following oral administration of 200, 400 and 800 mg/kg of Pu-erh tea and 100 mg/kg of bisacodyl, the gastrointestinal transit rates were shortened by 48.6, 59.6, 78.0 and 91.9%, respectively. Serum levels of motilin (MTL), gastrin (Gas), endothelin (ET), acetylcholine enzyme (AchE), substance P (SP) and vasoactive intestinal peptide (VIP) were significantly increased and somatostatin (SS) was decreased when the mice were treated with different concentrations of Pu-erh tea compared with the untreated control mice. These results demonstrate that Pu-erh tea has a similar preventive effect to bisacodyl and it may be used as a functional food to prevent constipation.
- Molecular medicine reports.Mol Med Rep.2014 May;9(5):2003-9. doi: 10.3892/mmr.2014.2009. Epub 2014 Mar 5.
- The aim of this study was to investigate the effects of Pu-erh tea on activated carbon-induced constipation in ICR mice. The changes in body weight, dietary intake, gastrointestinal transit, first black stool defecation time, number and weight of feces, water content of feces and various levels of s
- PMID 24604453
- Monitoring of 29 weight loss compounds in foods and dietary supplements by LC-MS/MS.
- Kim HJ1, Lee JH, Park HJ, Cho SH, Cho S, Kim WS.Author information 1a Advanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation , Ministry of Food and Drug Safety , Cheongwon-gun , Chungcheongbuk-do , Korea.AbstractBecause of the rapid growth in dietary supplement availability and public concern for weight control, the investigation of foods and various dietary supplements illegally adulterated with weight loss compounds has become increasingly important. A total of 29 weight loss compounds, including sennoside, sibutramine, ephedrine and their analogues, found to be adulterated in foods and dietary supplements were simultaneously examined by LC-MS/MS. The 188 samples were collected between 2009 and 2012 in South Korea, and method validation was performed to determine the adulterants to the weight loss compounds. LODs, LOQs and linearity ranged from 0.03 to 7.5 ng ml-1, from 0.08 to 30.00 ng ml-1, and from 0.990 to 0.999, respectively. The results showed that nine weight loss compounds, namely bisacodyl, desmethylsibutramine, didesmethylsibutramine, ephedrine, fluoxetine, pseudoephedrine, sennoside A, sennoside B and sibutramine, were detected in 62 of all collected samples and were found in order of frequency as follows: sibutramine, 25.7%; sennoside A, 22.9%; sennoside B, 20.0%; fluoxetine, 8.6%; desmethylsibutramine, 7.1%; bisacodyl, ephedrine, and pseudoephedrine, 4.3%; and didesmethylsibutramine, 2.9%. Sibutramine, which was the most frequently found adulterant, ranged in levels from 0.03 to 132.40 mg g-1 (2010), from 0.88 to 76.2 mg g-1 (2011), and from 0.07 to 0.24 mg g-1 (2012). Although the concentrations of most compounds ranged widely, some compounds such as bisacodyl and fluoxetine were found at high concentrations in several samples.
- Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2014 Mar 26. [Epub ahead of print]
- Because of the rapid growth in dietary supplement availability and public concern for weight control, the investigation of foods and various dietary supplements illegally adulterated with weight loss compounds has become increasingly important. A total of 29 weight loss compounds, including sennosid
- PMID 24499058
- Adjuncts to colonic cleansing before colonoscopy.
- Park S, Lim YJ.Author information Sanghoon Park, Department of Internal Medicine, KEPCO Medical Center, KEPCO Medical Foundation, Seoul 132-703, South Korea.AbstractPre-procedural cleansing of the bowel can maximize the effectiveness and efficiency of colonoscopy. Yet, efficacy of the current gold standard colonic preparation method - high-volume oral administration of purgative agents 12-24 h prior to the procedure - is limited by several factors, such as patient compliance (due to poor palatability and inconvenience of the dosing regimen) and risks of complications (due to drug interactions or intolerance). Attempts to resolve these limitations have included providing adjunctive agents and methods to promote the colonic cleansing ability of the principal purgative agent, with the aim of lessening unpleasant side effects (such as bloating) and reducing the large ingested volume requirement. Several promising adjunctive agents are bisacodyl, magnesium citrate, senna, simethicone, metoclopramide, and prokinetics, and each are being investigated for their potential. This review provides an up to date summary of the reported investigations into the potencies and weaknesses of the key adjuncts currently being applied in clinic as supplements to the traditional bowel preparation agents. While the comparative analysis of these adjuncts showed that no single agent or method has yet achieved the goal of completely overcoming the limitations of the current gold standard preparation method, they at least provide endoscopists with an array of alternatives to help improve the suboptimal efficacy of the main cleansing solutions when used alone. To aid in this clinical endeavor, a subjective grade was assigned to each adjunct to indicate its practical value. In addition, the systematic review of the currently available agents and methods provides insight into the features of each that may be overcome or exploited to create novel drugs and strategies that may become adopted as effective bowel cleansing adjuncts or alternatives.
- World journal of gastroenterology : WJG.World J Gastroenterol.2014 Mar 21;20(11):2735-2740.
- Pre-procedural cleansing of the bowel can maximize the effectiveness and efficiency of colonoscopy. Yet, efficacy of the current gold standard colonic preparation method - high-volume oral administration of purgative agents 12-24 h prior to the procedure - is limited by several factors, such as pati
- PMID 24659864
- An assessment of bisacodyl-based bowel preparation for colonoscopy in children
- SHAOUL RON,HALOON LINA
- Journal of gastroenterology 42(1), 26-28, 2007-01-01
- NAID 10018540784
- 臨床の実際 緩下剤bisacodyl大量服用中止後に高度の浮腫をきたした慢性便秘症の1例
- ビサコジル/成分ディクショナリーでは、ビサコジルについて解説しております。また「ビサコジル」を含む、エスエス製薬の製品についても掲載いたしております。 ... 便秘を改善する成分で、大腸の副交感神経末端に作用してぜん動 ...
- Bisacodyl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: stomach cramps faintness stomach discomfort Some side effects can be serious. If you experience this ...