- 同
- Survanta
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/07 15:01:54」(JST)
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Beractant
Clinical data |
Trade names |
Survanta, Alveofact |
Routes of
administration |
Endotracheal |
Legal status |
Legal status |
- UK: POM (Prescription only)
|
Identifiers |
CAS Number |
108778-82-1 Y |
ATC code |
none |
ChemSpider |
none |
UNII |
S866O45PIG Y |
ChEMBL |
CHEMBL1201624 N |
|
NY (what is this?) (verify) |
Beractant, also known by the trade name of Survanta, is a modified bovine pulmonary surfactant containing bovine lung extract (phospholipids, neutral lipids, fatty acids, and bovine surfactant proteins), to which synthetic DPPC, tripalmitin and palmitic acid are added. The composition provides 25 mg/mL phospholipids, 0.5 to 1.75 mg/mL triglycerides, 1.4 to 3.5 mg/mL free fatty acids, and <1.0 mg/mL total surfactant proteins.[1] As an intratracheal suspension, it can be used for the prevention and treatment of neonatal respiratory distress syndrome.[2]
References
- ^ Moya, F. R.; Gadzinowski, J.; Bancalari, E.; Salinas, V.; Kopelman, B.; Bancalari, A.; Kornacka, M. K.; Merritt, T. A.; Segal, R.; Schaber, C. J.; Tsai, H.; Massaro, J.; d'Agostino, R. (1 April 2005). "A Multicenter, Randomized, Masked, Comparison Trial of Lucinactant, Colfosceril Palmitate, and Beractant for the Prevention of Respiratory Distress Syndrome Among Very Preterm Infants". PEDIATRICS 115 (4): 1018–1029. doi:10.1542/peds.2004-2183.
- ^ Lotze, Andrea; Mitchell, Brian R.; Bulas, Dorothy I.; Zola, Elizabeth M.; Shalwitz, Robert A.; Gunkel, J.Harry (January 1998). "Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure". The Journal of Pediatrics 132 (1): 40–47. doi:10.1016/S0022-3476(98)70482-2.
UpToDate Contents
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English Journal
- Improvement of pulmonary surfactant activity by introducing D-amino acids into highly hydrophobic amphiphilic α-peptide Hel 13-5.
- Nakamura Y1, Yukitake K2, Nakahara H3, Lee S4, Shibata O5, Lee S6.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Aug;1838(8):2046-52. doi: 10.1016/j.bbamem.2014.04.024. Epub 2014 May 2.
- The high costs of artificial pulmonary surfactants, ranging in hundreds per kilogram of body weight, used for treating the respiratory distress syndrome (RDS) premature babies have limited their applications. We have extensively studied soy lecithins and higher alcohols as lipid alternatives to expe
- PMID 24796503
- Neurodevelopmental outcomes of very low birth weight preterm infants treated with poractant alfa versus beractant for respiratory distress syndrome.
- Eras Z, Dizdar EA, Kanmaz G, Guzoglu N, Aksoy HT, Altunkaya GB, Canpolat FE, Dilmen U.
- American journal of perinatology.Am J Perinatol.2014 Jun;31(6):463-8. doi: 10.1055/s-0033-1351659. Epub 2013 Jul 24.
- BACKGROUND: Some controlled trials have shown significant differences in short-term clinical outcomes between poractant alfa and beractant in infants with respiratory distress syndrome (RDS). There is, however, no study showing the differences in long-term outcomes with these treatments.AIM: To dete
- PMID 23884719
- Perfusion Index Variability in Preterm Infants Treated with Two Different Natural Surfactants for Respiratory Distress Syndrome.
- Karadag N, Dilli D, Zenciroglu A, Aydin B, Beken S, Okumus N.
- American journal of perinatology.Am J Perinatol.2014 Feb 24. [Epub ahead of print]
- Objective The objective of this study was to compare the perfusion index (PI) variability in premature infants with respiratory distress syndrome (RDS) following administration of two different natural surfactant preparations. Study design This was a prospective study on 92 preterm infants with
- PMID 24566756
Japanese Journal
- Surfactant (Beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: Evidence of persistent surfactant deficiency.
Related Links
- Learn about SURVANTA® (beractant) dosing, administration, safety and efficacy for prevention and treatment of respiratory distress syndrome (RDS) ... SAFETY CONSIDERATIONS 2 SURVANTA is intended for intratracheal use ...
- Beractant is a lung surface acting agent, or "surfactant." It helps the lungs function normally. Beractant is similar to the natural fluid in the lungs that helps maintain effective breathing. Beractant is used to treat or prevent respiratory ...
Related Pictures
★リンクテーブル★
[★]
- 英
- surface active agent
- 同
- pulmonary surfactant 肺サーファクタント、肺胞界面活性物質
- 商
- サーファクテン
- 関
- L/S比
[show details]
- 胎児のII型肺胞上皮細胞で在胎20週ころから産生され始め、在胎32週以降に急激に産生が増加する (PED.396) → 胎児#胎児の成長
- 胎児の肺は妊娠26週には構造が完成し、妊娠34週頃には肺のサーファクタント産生が十分量に達して機能的に成熟(G10M.144)
- 肺サーファクタントが羊水に出現するのは妊娠28-32週ごろ (出典不明)
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