- バルーン損傷の
WordNet
- become inflated; "The sails ballooned" (同)inflate, billow
- large tough nonrigid bag filled with gas or heated air
- small thin inflatable rubber bag with narrow neck
- ride in a hot-air balloon; "He tried to balloon around the earth but storms forced him to land in China"
- cause injuries or bodily harm to (同)wound
- harmed; "injured soldiers"; "injured feelings"
- flying in a balloon
PrepTutorEJDIC
- 『気球』,軽気球 / (おもちゃの)風船 / (気球のように)ふくれる《+『out』(『up』)》 / (気球のように)ふくれた
- …‘を'『傷つける』,‘に'損害を与える / 〈感情・名声など〉‘を'『傷つける』,害する
- (身体が)傷つけられた / (感情・名声などが)傷つけられた
- 気球操縦競技
UpToDate Contents
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- 1. 総胆管結石除去のための内視鏡的バルーン拡張術 endoscopic balloon dilatation for removal of bile duct stones
- 2. 大動脈内バルーンポンプカウンターパルセーション intraaortic balloon pump counterpulsation
- 3. 産後出血を制御するための子宮内バルーンタンポナーデ intrauterine balloon tamponade for control of postpartum hemorrhage
- 4. 小腸内視鏡の概要 overview of deep small bowel enteroscopy
- 5. 総胆管結石の内視鏡マネージメント：標準手技および機械的砕石 endoscopic management of bile duct stones standard techniques and mechanical lithotripsy
English Journal
- Role of peroxisome proliferator‑activated receptor α in atherosclerosis.
- Cao H, Wen G, Li H.Author information Department of Cardiology, Shanghai First People's Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200080, P.R. China.AbstractAtherosclerosis is an inflammatory disease involving the immune response. In addition to lowering the cholesterol level, the peroxisome proliferator-activated receptor α (PPAR-α) can prevent atherosclerosis via its pleiotropic anti-inflammatory effects. However, the role of PPAR-α in modulating inflammatory progression of atherosclerosis has rarely been studied. Thus, we aimed to investigate the role of PPAR-α in atherosclerosis by evaluating the expression of inflammatory cytokines induced by PPAR-α in an in vivo rabbit model. New Zealand White rabbits were randomly divided into 5 groups: control, high-fat diet + balloon injury, high-fat diet + balloon injury + placebo, high-fat diet + balloon injury + fenofibrate, and high-fat diet + balloon injury + WY-14643. The femoral arteries of rabbits were balloon-injured after initiation of the high-fat diet and before administration of fenofibrate, WY-14643 or placebo solution. Atherosclerosis was induced by high-fat diet and balloon angioplasty, and the vessel wall lumen occlusion was determined by measuring the stenosis rate. PPAR-α gene expression was examined by quantitative polymerase chain reaction analysis. The cellular localization and distribution of PPAR-α was observed by immunohistochemistry, and its protein level was assessed by western blot analysis. The production of interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and P-selectin, which are major inflammatory factors involved in atherosclerosis, was monitored by an enzyme-linked immunosorbent assay (ELISA). Treatment with PPAR-α agonists (fenofibrate or WY-14643) reduced the vascular occlusion rate, as compared to the high‑fat diet + balloon injury and the placebo groups. Furthermore, the expression of PPAR-α at both the protein and the mRNA level was increased in the fenofibrate and WY-14643 groups. According to the results, the TNF-α and P-selectin levels were reduced in the fenofibrate and WY-14643 groups. These results suggest that PPAR-α activation can attenuate the effects of atherosclerosis by inhibiting the expression of major inflammatory factors in a rabbit atherosclerosis model.
- Molecular medicine reports.Mol Med Rep.2014 May;9(5):1755-60. doi: 10.3892/mmr.2014.2020. Epub 2014 Mar 6.
- Atherosclerosis is an inflammatory disease involving the immune response. In addition to lowering the cholesterol level, the peroxisome proliferator-activated receptor α (PPAR-α) can prevent atherosclerosis via its pleiotropic anti-inflammatory effects. However, the role of PPAR-α in modulating
- PMID 24604149
- Periluminal Expression of a Secreted Transforming Growth Factor-β Type II Receptor Inhibits In-Stent Neointima Formation Following Adenovirus-Mediated Stent-Based Intracoronary Gene Transfer.
- Appleby CE1, Ranjzad P, Williams PD, Kakar SJ, Driessen A, Tijsma E, Fernandes B, Heagerty AM, Kingston PA.Author information 11 Institute of Cardiovascular Sciences, Manchester Academic Health Science Centre, The University of Manchester , Manchester M13 9NT, United Kingdom .AbstractAbstract Transforming growth factor-β1 (TGF-β1) has been shown unequivocally to enhance neointima formation in carotid and ileo-femoral arteries. In our previous studies, however, TGF-β1 expression in coronary arteries actually reduced neointima formation without affecting luminal loss postangioplasty, while expression of a TGF-β1 antagonist (RIIs) in balloon-injured coronary arteries reduced luminal loss without affecting neointima formation. These observed effects may be a consequence of the mode of coronary artery gene transfer employed, but they may also represent differences in the modes of healing of coronary, carotid, and ileo-femoral arteries after endoluminal injury. To help clarify whether a gene therapy strategy to antagonize TGF-β might have application within the coronary vasculature, we have investigated the effect of high-level periluminal expression of RIIs using stent-based adenovirus-mediated intracoronary gene transfer. Porcine coronary arteries were randomized to receive a custom-made CoverStent preloaded with saline only, or with 1×109 infectious units of adenovirus expressing RIIs or β-galactosidase (lacZ). Vessels were analyzed 28 days poststenting, at which time angiographic in-stent diameter was significantly greater in RIIs-treated arteries, and in-stent luminal loss significantly reduced. Computerized morphometric minimum in-stent lumen area was ∼300% greater in RIIs-exposed vessels than in lacZ or saline-only groups. This was because of significantly reduced neointima formation in the RIIs group. RIIs had no demonstrable effect on cellular proliferation or apoptosis, but greater normalized neointimal/medial collagen content was observed in RIIs-exposed arteries. These data highlight the qualitatively similar effect of TGF-β antagonism on neointima formation in injured coronary and noncoronary arteries, and suggest that since cellular proliferation is unaffected, TGF-β1 antagonism might prevent in-stent restenosis without the delayed healing that is associated with drug-eluting stents in current clinical use.
- Human gene therapy.Hum Gene Ther.2014 Mar 24. [Epub ahead of print]
- Abstract Transforming growth factor-β1 (TGF-β1) has been shown unequivocally to enhance neointima formation in carotid and ileo-femoral arteries. In our previous studies, however, TGF-β1 expression in coronary arteries actually reduced neointima formation without affecting luminal loss postangiop
- PMID 24483849
- Resveratrol inhibits phenotypic switching of neointimal vascular smooth muscle cells after balloon injury through blockade of notch pathway.
- Zhang J1, Chen J, Xu C, Yang J, Guo Q, Hu Q, Jiang H.Author information 1*Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; †Departments of Cardiology; and ‡Ophthalmology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, China.AbstractBACKGROUND: Phenotypic switching of vascular smooth muscle cells (VSMCs) plays an initial role in neointimal hyperplasia, the main cause of many occlusive vascular diseases. The aim of this study was to measure the effects of resveratrol (RSV) on the phenotypic transformation of VSMCs and to investigate its mechanism of action.
- Journal of cardiovascular pharmacology.J Cardiovasc Pharmacol.2014 Mar;63(3):233-9. doi: 10.1097/FJC.0000000000000040.
- BACKGROUND: Phenotypic switching of vascular smooth muscle cells (VSMCs) plays an initial role in neointimal hyperplasia, the main cause of many occlusive vascular diseases. The aim of this study was to measure the effects of resveratrol (RSV) on the phenotypic transformation of VSMCs and to investi
- PMID 24603118
Japanese Journal
- Naringenin Inhibits Angiotensin Ⅱ-Induced Vascular Smooth Muscle Cells Proliferation and Migration and Decreases Neointimal Hyperplasia in Balloon Injured Rat Carotid Arteries through Suppressing Oxidative Stress
- Biological and Pharmaceutical Bulletin 36(10), 1549-1555, 2013
- NAID 130003361540
- Impact of Acute Gain on Clinical Outcomes of Patients Treated With Sirolimus-Eluting Stent : A Sub-Analysis Study From the STLLR Trial
- Circulation journal : official journal of the Japanese Circulation Society 75(9), 2113-2119, 2011-08-25
- NAID 10029339376
- ブタ冠動脈バルーン障害モデルの内膜肥厚部位におけるヒスチジン脱炭酸酵素発現の免疫組織化学的検討
- 昭和大学薬学雑誌 1(2), 205-212, 2010-12
- NAID 40018735990
Related Links
- Balloon Injury The thoracic aorta was balloon injured 3.1±0.1 (range 1 to 5) days before experiments in vivo as follows. Each rabbit was anesthetized with pentobarbital (30 to 50 mg/kg IV) and a 4F embolectomy ...
- WELLINGTON, New Zealand — A New Zealand truck driver said he blew up like a balloon when he fell onto the fitting of a compressed air hose that pierced his buttock and forced air into his body at 100 pounds a ...
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★リンクテーブル★
| リンク元 | 「balloon injury」「バルーン損傷」 |
| 関連記事 | 「injure」「balloon」「ballooning」 |
「balloon injury」
「バルーン損傷」
「injure」
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「balloon」
「ballooning」
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