同: ASCUS

WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
not representative of a group, class, or type; "a group that is atypical of the target audience"; "a class of atypical mosses"; "atypical behavior is not the accepted type of response that we expect from children" (同)untypical
deviating from normal expectations; somewhat odd, strange, or abnormal; "these days large families are atypical"; "atypical clinical findings"; "atypical pneumonia"; "highly irregular behavior" (同)irregular
a meaning that is not expressly stated but can be inferred; "the significance of his remark became clear only later"; "the expectation was spread both by word and by implication" (同)import, implication
the quality of being significant; "do not underestimate the significance of nuclear power"
not yet having been ascertained or determined; "of undetermined species"

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
型にはまらない,異常な
『重要性』,重大さ(importance) / (…の)『意味』,意義(meaning)《+『of』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/03 14:41:37」(JST)

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The Bethesda system (TBS) is a system for reporting cervical or vaginal cytologic diagnoses,^[1] used for reporting Pap smear results. It was introduced in 1988,^[2] and revised in 1991 ^[3] and 2001.^[1]^[4]^[5] The name comes from the location (Bethesda, Maryland) of the conference that established the system.

Types of results

Abnormal results include:

Atypical squamous cells
- Atypical squamous cells of undetermined significance (ASC-US)
- Atypical squamous cells – cannot exclude HSIL (ASC-H)
Low grade squamous intraepithelial lesion (LGSIL or LSIL)
High grade squamous intraepithelial lesion (HGSIL or HSIL)
Squamous cell carcinoma

Atypical Glandular Cells not otherwise specified (AGC-NOS)
Atypical Glandular Cells, suspicious for AIS or cancer (AGC-neoplastic)

Adenocarcinoma in situ (AIS)

Squamous cell abnormalities

LSIL – Low-grade Squamous Intraepithelial Lesion

LSIL. Pap stain.

Low grade squamous intraepithelial lesion (LSIL or LGSIL) indicates possible cervical dysplasia. LSIL usually indicates mild dysplasia (CIN 1), more than likely caused by a human papillomavirus infection. It is usually diagnosed following a Pap smear.

CIN 1 is the most common and most benign form of cervical intraepithelial neoplasia and usually resolves spontaneously within two years. Because of this, LSIL results can be managed with a simple "watch and wait" philosophy. However, because there is a 12–16% chance of progression to more severe dysplasia, the physician may want to follow the results more aggressively by performing a colposcopy with biopsy.^[6] If the dysplasia progresses, treatment may be necessary. Treatment involves removal of the affected tissue, which can be accomplished by LEEP, cryosurgery, cone biopsy, or laser ablation.

HSIL – High-grade Squamous Intraepithelial Lesion

HSIL. Pap stain.

High grade squamous intraepithelial lesion (HSIL or HGSIL) indicates moderate or severe cervical intraepithelial neoplasia or carcinoma in situ. It is usually diagnosed following a Pap test. In some cases these lesions can lead to invasive cervical cancer, if not followed appropriately.

HSIL does not mean that cancer is present. Of all women with HSIL results, 2%^[7] or less^[8] have invasive cervical cancer at that time, however about 20% would progress to having invasive cervical cancer without treatment.^[9] To combat this progression, HSIL is usually followed by an immediate colposcopy with biopsy to sample or remove the dysplastic tissue. This tissue is sent for pathology testing to assign a histologic classification that is more definitive than a Pap smear result (which is a cytologic finding). HSIL generally corresponds to the histological classification of CIN 2 or 3.

HSIL treatment involves the removal or destruction of the affected cells, usually by LEEP. Other methods include cryotherapy, cautery, or laser ablation, but none are performed on pregnant women for fear of disrupting the pregnancy.^[10] Any of these procedures is 85% likely to cure the problem.

Glandular cell abnormalities

Adenocarcinoma

Adenocarcinoma. Pap stain.

Adenocarcinoma can arise from the endocervix, endometrium and extrauterine sites.

AGC

AGC, formerly AGUS, is an acronym for atypical glandular cells of undetermined significance.^[11] Renamed AGC to avoid confusion with ASCUS.^[1]

The management of AGC is colposcopy with or without an endometrial biopsy.^{[citation needed]}

References

^ ^a ^b ^c Apgar BS, Zoschnick L, Wright TC (November 2003). "The 2001 Bethesda System terminology". Am Fam Physician 68 (10): 1992–8. PMID 14655809.
^ "The 1988 Bethesda System for reporting cerval/vaginal cytologic diagnoses: developed and approved at the National Cancer Institute workshop in Bethesda, MD, December 12–13, 1988". Diagn. Cytopathol. 5 (3): 331–4. 1989. doi:10.1002/dc.2840050318. PMID 2791840.
^ Broder S (1992). "The Bethesda System for Reporting Cervical/Vaginal Cytologic Diagnoses—Report of the 1991 Bethesda Workshop". JAMA 267: 1892. doi:10.1001/jama.1992.03480140014005.
^ Nayar R, Solomon D. Second edition of 'The Bethesda System for reporting cervical cytology' – Atlas, website, and Bethesda interobserver reproducibility project. CytoJournal [serial online] 2004 [cited 2011 Apr 17];1:4. Available from: http://www.cytojournal.com/text.asp?2004/1/1/4/41272
^ Solomon D, Davey D, Kurman R; et al. (April 2002). "The 2001 Bethesda System: terminology for reporting results of cervical cytology". JAMA 287 (16): 2114–9. doi:10.1001/jama.287.16.2114. PMID 11966386.
^ Wright TC Jr, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D (Oct 2007). "2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests". Am J Obstet Gynecol 197 (4): 346–55. doi:10.1016/j.ajog.2007.07.047.
^ Massad LS; Collins YC; Meyer PM. Biopsy correlates of abnormal cervical cytology classified using the Bethesda system. Gynecologic Oncology. 2001 Sep;82(3):516-22.
^ Melnikow J, Nuovo J, Willan AR, Chan BK, Howell LP. Natural history of cervical squamous intraepithelial lesions: a meta-analysis. Obstetric Gynecology. 1998 Oct;92(4 Pt 2):727-35.
^ McIndoe WA; McLean MR; Jones RW; Mullins PR. The invasive potential of carcinoma in situ of the cervix. Obstetric Gynecology. 1984 Oct;64(4):451-8.
^ Wright TC Jr; Massad LS; Dunton CJ; Spitzer M; Wilkinson EJ; Solomon D. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. American Journal of Obstetric Gynecology. 2007 Oct;197(4):346-55.
^ AGUS at eMedicine Dictionary

External links

ASCP: The Bethesda System Website Atlas
Bethesda 2001 Workshop

UpToDate Contents

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1. 子宮頚部細胞診：異型扁平上皮細胞（ASC-USおよびASC-H）の評価 cervical cytology evaluation of atypical squamous cells asc us and asc h
2. 患者情報：異型扁平上皮細胞（(ASC-USおよびASC-H）ならびに
軽度子宮頚部扁平上皮内病変（LSIL）の管理（詳細） management of atypical squamous cells asc us and asc h and low grade cervical squamous intraepithelial lesions lsil beyond the basics
3. 子宮頸癌スクリーニング：有効性のエビデンス cervical cancer screening tests evidence of effectiveness
4. 子宮頸部上皮内腫瘍：管理 cervical intraepithelial neoplasia management
5. 子宮頚部細胞診：結果の解釈 cervical cytology interpretation of results

English Journal

DNA methylation in human papillomavirus-infected cervical cells is elevated in high-grade squamous intraepithelial lesions and cancer.

Kim MK1, Lee IH1, Lee KH1, Lee YK1, So KA1, Hong SR2, Hwang CS3, Kee MK4, Rhee JE4, Kang C4, Hur SY5, Park JS5, Kim TJ6.
Journal of gynecologic oncology.J Gynecol Oncol.2016 Mar;27(2):e14. doi: 10.3802/jgo.2016.27.e14.
OBJECTIVE: DNA methylation has been shown to be a potential biomarker for early cancer detection. The aim of this study was to evaluate DNA methylation profiles according to liquid-based Pap (LBP) test results and to assess their diagnostic value in a Korean population.METHODS: A total of 205 patien
PMID 26768780

Reproducibility of cervical cytopathology following an intervention by an external quality control laboratory.

Ázara CZ1, Manrique EJ2, Tavares SB1, Alves de Souza NL1, Magalhães JC3, Amaral RG1,4.
Diagnostic cytopathology.Diagn Cytopathol.2016 Feb 5. doi: 10.1002/dc.23445. [Epub ahead of print]
BACKGROUND: This study assessed the effects of a continued education program on the agreement between cervical cytopathology exams interpreted by local laboratories and interpretation made by an external quality control laboratory (LabMEQ).METHODS: Overall, 9,798 exams were analyzed between 2007 and
PMID 26848707

High-Grade Cervical Intraepithelial Neoplasia Detected by Colposcopy-Directed or Random Biopsy Relative to Age, Cytology, Human Papillomavirus 16, and Lesion Size.

Chen Q1, Du H, Pretorius RG, Wang C, Yang B, Wang G, Tang J, Belinson JL, Wu R.
Journal of lower genital tract disease.J Low Genit Tract Dis.2016 Feb 5. [Epub ahead of print]
OBJECTIVE: The aim of the study was to determine whether p16 positive/cervical intraepithelial neoplasia (CIN) 2, 3, and cancer (p16 + CIN 2/3+) detected by colposcopy-directed or random biopsy differ by age, referral cytology, human papillomavirus (HPV) 16, and lesion size.MATERIALS AND METHODS: Da
PMID 26855144

Japanese Journal

Prevalence of High-Risk Human Papillomavirus (HR-HPV) Infection among Women with Normal and Abnormal Cervical Cytology in Myanmar

Acta Medica Okayama 68(2), 79-87, 2014-04
NAID 120005425626

当院検査部におけるベセスダシステム ASC-US 亜分類の試みとその有用性についての検討

日本臨床細胞学会雑誌 53(6), 441-445, 2014
NAID 130004885821

子宮頸癌細胞診におけるスコアリングシステムを用いたASC-US の評価:—NILM, ASCUS-NOS と ASCUS-D 鑑別のポイント—

日本臨床細胞学会雑誌 53(6), 435-440, 2014
NAID 130004885820

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