aspartate-ammonia ligase

アスパラギン酸アンモニアリガーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/24 07:39:05」(JST)

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aspartate-ammonia ligase
Identifiers
EC number	6.3.1.1
CAS number	9023-69-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an aspartate-ammonia ligase (EC 6.3.1.1) is an enzyme that catalyzes the chemical reaction

ATP + L-aspartate + NH₃ $\rightleftharpoons$ AMP + diphosphate + L-asparagine

The 3 substrates of this enzyme are ATP, L-aspartate, and NH₃, whereas its 3 products are AMP, diphosphate, and L-asparagine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (AMP-forming). Other names in common use include asparagine synthetase, and L-asparagine synthetase. This enzyme participates in 3 metabolic pathways: alanine and aspartate metabolism, cyanoamino acid metabolism, and nitrogen metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 11AS and 12AS.

References

• RAVEL JM, NORTON SJ, HUMPHREYS JS, SHIVE W (1962). "Asparagine biosynthesis in Lactobacillus arabinosus and its control by asparagine through enzyme inhibition and repression". J. Biol. Chem. 237: 2845–9. PMID 14490631. 
• Webster GC & Varner JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems". J. Biol. Chem. 215: 91–99. PMID 14392145. 

UpToDate Contents

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English Journal

• Epileptic Phenotype of Two Siblings with Asparagine Synthesis Deficiency Mimics Neonatal Pyridoxine-Dependent Epilepsy.

• Gataullina S1, Lauer-Zillhardt J2, Kaminska A1, Galmiche-Rolland L3, Bahi-Buisson N4, Pontoizeau C5, Ottolenghi C5, Dulac O1, Fallet-Bianco C6.
• Neuropediatrics.Neuropediatrics.2016 Dec;47(6):399-403. Epub 2016 Aug 14.
• PMID 27522229

• TiO2 nanoparticle-induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice.

• Ze X1, Su M2, Zhao X1, Jiang H1, Hong J1, Yu X1, Liu D1, Xu B1, Sheng L1, Zhou Q1, Zhou J1, Cui J1, Li K1, Wang L3, Ze Y1, Hong F1.
• Environmental toxicology.Environ Toxicol.2016 Jun;31(6):655-62. doi: 10.1002/tox.22077. Epub 2014 Nov 20.
• PMID 25411160

• Flooding of the root system in soybean: biochemical and molecular aspects of N metabolism in the nodule during stress and recovery.

• Souza SC1, Mazzafera P2, Sodek L2.
• Amino acids.Amino Acids.2016 May;48(5):1285-95. doi: 10.1007/s00726-016-2179-2. Epub 2016 Jan 29.
• PMID 26825550

Related Links

• Aspartate—ammonia ligase - Wikipedia, the free encyclopedia

In enzymology, an aspartate-ammonia ligase (EC 6.3.1.1) is an enzyme that catalyzes the chemical reaction ... The 3 substrates of this enzyme are ATP, L- aspartate, and NH3, whereas its 3 products are AMP, diphosphate, and L- asparagine.

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★リンクテーブル★

リンク元	「アスパラギン酸アンモニアリガーゼ」
関連記事	「aspartate」「ligase」「ammonia」

「アスパラギン酸アンモニアリガーゼ」

　　[★]

英

aspartate-ammonia ligase

「aspartate」

　　[★] アスパラギン酸、アスパラギン酸塩

関

Asp、aspartic、aspartic acid、D、L-aspartate、L-aspartic acid、magnesium aspartate、potassium aspartate

aspartic acid

「ligase」

　　[★]

リガーゼ、連結酵素

関

synthetase

「ammonia」

　　[★] アンモニア NH3