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Structural Analysis of Aliphatic versus Aromatic Substrate Specificity in a Copper Amine Oxidase from Hansenula polymorpha.

Klema VJ, Solheid CJ, Klinman JP, Wilmot CM.SourceDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Biochemistry.Biochemistry.2013 Apr 2;52(13):2291-301. doi: 10.1021/bi3016845. Epub 2013 Mar 22.
Copper amine oxidases (CAOs) are responsible for the oxidative deamination of primary amines to their corresponding aldehydes. The CAO catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding aldehyde wi
PMID 23452079

Kaitaniemi S, Grön K, Elovaara H, Salmi M, Jalkanen S, Elima K.SourceMediCity Research Laboratory, University of Turku, Turku, Finland.
PloS one.PLoS One.2013;8(1):e54151. doi: 10.1371/journal.pone.0054151. Epub 2013 Jan 18.
Vascular Adhesion Protein-1 (VAP-1) is an endothelial adhesion molecule belonging to the primary amine oxidases. Upon inflammation it takes part in the leukocyte extravasation cascade facilitating transmigration of leukocytes into the inflamed tissue. Screening of a human lung cDNA library revealed
PMID 23349812

Synthesis of ortho-Functionalized 4-Aminomethylpyridazines as Substrate-Like Semicarbazide-Sensitive Amine Oxidase Inhibitors

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Chemical and Pharmaceutical Bulletin 58(7), 964-970, 2010
… The new compounds were tested in vitro for semicarbazide-sensitive amine oxidase (SSAO) inhibitory activity and 4-(aminomethyl)-N,N′-diethylpyridazine-3,5-diamine (22) was found to be the most active representative. …
NAID 130000299795

Purification and Characterization of a Copper-Containing Amine Oxidase from Mycobacterium Sp. Strain JC1 DSM 3803 Grown on Benzylamine

Substrate Selectivity of Monoamine Oxidase A, Monoamine Oxidase B, Diamine Oxidase, and Semicarbazide-Sensitive Amine Oxidase in COS-1 Expression Systems(Biochemistry)

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Biological & pharmaceutical bulletin 29(12), 2362-2366, 2006-12-01
… The substrate selectivity of monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), diamine oxidase (DAO), and semicarbazide-sensitive amine oxidase (SSAO) was investigated in the absence of chemical inhibitors using the COS-1 cells expressed with respective amine oxidase. … In contrast, benzylamine, tyramine, and β-phenylethylamine served as substrates for all of MAO-A, MAO-B, and SSAO. …
NAID 110006148653