- 関
- copper amine oxidase、copper-containing amine oxidase、histaminase
- 同
- DAO
- 同
- DAO
WordNet
- enzyme that acts as a catalyst in converting histidine to histamine
- any of the enzymes that catalyze biological oxidation
- any organic compound containing two amino groups
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/01 21:24:49」(JST)
[Wiki en表示]
Ribbon representation of human diamine oxidase.
[1]
amiloride binding protein 1 (amine oxidase (copper-containing)) |
Identifiers |
Symbol |
ABP1 |
Alt. symbols |
AOC1 |
Entrez |
26 |
HUGO |
80 |
OMIM |
104610 |
RefSeq |
NM_001091 |
UniProt |
P19801 |
Other data |
EC number |
1.4.3.22 |
Locus |
Chr. 7 q34-qter |
Amine oxidase (copper-containing), also known as histaminase or diamine oxidase, is an enzyme involved in the metabolism, oxidation, and inactivation of histamine in animals. Highest content is observed in the digestive tract and placenta.
[2]
External links
- García-Martín, E; Ayuso, P; Martínez, C; Blanca, M; Agúndez, JA (May 2009). "Histamine pharmacogenomics". Pharmacogenomics 10 (5): 867–83. doi:10.2217/pgs.09.26. PMID 19450133.
- García-Martín, E; Ayuso, P; Martínez, C; Agúndez, JA (Nov 2007). "Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals". Clin Biochem 40 (16-17): 1339–41. doi:10.1016/j.clinbiochem.2007.07.019. PMID 17826755.
- Ayuso, P; García-Martín, E; Martínez, C; Agúndez, JA (Sep 2007). "Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity". Pharmacogenet Genomics 17 (9): 687–93. doi:10.1097/FPC.0b013e328012b8e4. PMID 17700358.
- García-Martín, E; García-Menaya, J; Sánchez, B; Martínez, C; Rosendo, R; Agúndez, JA (Aug 2007). "Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis". Clin Exp Allergy 37 (8): 1175–82. doi:10.1111/j.1365-2222.2007.02769.x. PMID 17651147.
- García-Martin, E; Mendoza, JL; Martínez, C; Taxonera, C; Urcelay, E; Ladero, JM; de la Concha, EG; Díaz-Rubio, M; Agúndez, JA (Jan 2006). "Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene". World J Gastroenterol 12 (4): 615–20. PMID 16489678.
- Amine Oxidase (Copper-Containing) at the US National Library of Medicine Medical Subject Headings (MeSH)
CH-NH2 oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
|
|
1.4.1: NAD/NADP acceptor |
- Glutamate dehydrogenase
- Glutamate synthase (NADPH)
|
|
1.4.3: oxygen acceptor |
- D-amino acid oxidase
- Amine oxidase
- Lysyl oxidase
- Monoamine oxidase
|
|
1.4.4: disulfide acceptor |
|
|
1.4.99: other acceptors |
- D-amino acid dehydrogenase
- Amine dehydrogenase
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
Enzymes involved in neutrotransmission
|
|
monoamine |
histidine → histamine |
anabolism: |
|
|
catabolism: |
- Histamine N-methyltransferase
- Amine oxidase
|
|
|
tyrosine→dopamine→epinephrine |
anabolism: |
- Tyrosine hydroxylase
- Aromatic L-amino acid decarboxylase
- Dopamine beta hydroxylase
- Phenylethanolamine N-methyltransferase
|
|
catabolism: |
- Catechol-O-methyl transferase
- Monoamine oxidase
|
|
|
glutamate→GABA |
anabolism: |
|
|
catabolism: |
- 4-aminobutyrate transaminase
|
|
|
tryptophan→serotonin→melatonin |
- Tryptophan hydroxylase
- Aromatic L-amino acid decarboxylase
- Acetylserotonin O-methyltransferase
|
|
|
arginine→NO |
- Nitric oxide synthase (NOS1, NOS2, NOS3)
|
|
choline→Acetylcholine |
anabolism: |
- Choline acetyltransferase
|
|
catabolism: |
- Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase)
|
|
|
Index of the central nervous system
|
|
Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
|
|
Disease |
- Cerebral palsy
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
- Tests
|
|
Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- addiction
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
|
|
|
Histaminergics
|
|
Receptor
(ligands) |
H1 |
- Agonists: 2-Pyridylethylamine
- Betahistine
- Histamine
- HTMT
- UR-AK49
- Antagonists: First-generation: 4-Methyldiphenhydramine
- Alimemazine
- Antazoline
- Azatadine
- Bamipine
- Benzatropine (benztropine)
- Bepotastine
- Bromazine
- Brompheniramine
- Buclizine
- Captodiame
- Carbinoxamine
- Chlorcyclizine
- Chloropyramine
- Chlorothen
- Chlorphenamine
- Chlorphenoxamine
- Cinnarizine
- Clemastine
- Clobenzepam
- Clocinizine
- Cyclizine
- Cyproheptadine
- Dacemazine
- Decloxizine
- Deptropine
- Dexbrompheniramine
- Dexchlorpheniramine
- Dimenhydrinate
- Dimetindene
- Diphenhydramine
- Diphenylpyraline
- Doxylamine
- Embramine
- Etodroxizine
- Etybenzatropine (ethylbenztropine)
- Etymemazine
- Flunarizine
- Histapyrrodine
- Homochlorcyclizine
- Hydroxyethylpromethazine
- Hydroxyzine
- Isopromethazine
- Isothipendyl
- Meclozine
- Medrylamine
- Mepyramine (pyrilamine)
- Mequitazine
- Methafurylene
- Methapyrilene
- Methdilazine
- Moxastine
- Orphenadrine
- Oxatomide
- Oxomemazine
- Phenindamine
- Pheniramine
- Phenyltoloxamine
- Pimethixene
- Piperoxan
- Pipoxizine
- Promethazine
- Propiomazine
- Pyrrobutamine
- Talastine
- Thenalidine
- Thenyldiamine
- Thiazinamium
- Thonzylamine
- Tolpropamine
- Tripelennamine
- Triprolidine
- Second/third-generation: Acrivastine
- Alinastine
- Astemizole
- Azelastine
- Bamirastine
- Barmastine
- Bepiastine
- Bepotastine
- Bilastine
- Cabastinen
- Carebastine
- Cetirizine
- Clemastine
- Clemizole
- Clobenztropine
- Desloratadine
- Dorastine
- Ebastine
- Efletirizine
- Emedastine
- Epinastine
- Fexofenadine
- Flezelastine
- Ketotifen
- Latrepirdine
- Levocabastine
- Levocetirizine
- Linetastine
- Loratadine
- Mapinastine
- Mebhydrolin
- Mizolastine
- Moxastine
- Noberastine
- Octastine
- Olopatadine
- Perastine
- Pibaxizine
- Piclopastine
- Rocastine
- Rupatadine
- Setastine
- Talastine
- Temelastine
- Terfenadine
- Vapitadine
- Zepastine
- Non-generational: Atypical antipsychotics (e.g., aripiprazole, asenapine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine)
- Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline)
- Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine)
- Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene)
- Unknown/unsorted: Belarizine
- Elbanizine
- Flotrenizine
- Napactadine
- Tagorizine
- Trelnarizine
- Trenizine
|
|
H2 |
- Agonists: Amthamine
- Betazole
- Dimaprit
- Histamine
- HTMT
- Impromidine
- UR-AK49
- Antagonists: Bisfentidine
- Burimamide
- Cimetidine
- Dalcotidine
- Donetidine
- Ebrotidine
- Etintidine
- Famotidine
- Lafutidine
- Lamtidine
- Lavoltidine (loxtidine)
- Lupitidine
- Metiamide
- Mifentidine
- Niperotidine
- Nizatidine
- Osutidine
- Oxmetidine
- Pibutidine
- Quisultazine (quisultidine)
- Ramixotidine
- Ranitidine
- Roxatidine
- Sufotidine
- Tiotidine
- Tuvatidine
- Venritidine
- Xaltidine
|
|
H3 |
- Agonists: α-Methylhistamine
- Cipralisant
- Histamine
- Imetit
- Immepip
- Immethridine
- Methimepip
- Proxyfan
- Antagonists: A-349,821
- A-423,579
- ABT-239
- ABT-652
- AZD5213
- Betahistine
- Burimamide
- Ciproxifan
- Clobenpropit
- Conessine
- GSK-189,254
- Impentamine
- Iodophenpropit
- Irdabisant
- JNJ-5207852
- MK-0249
- NNC 38-1049
- PF-03654746
- Pitolisant
- SCH-79687
- Thioperamide
- VUF-5681
|
|
H4 |
- Agonists: 4-Methylhistamine
- α-Methylhistamine
- Histamine
- VUF-8430
- Antagonists: JNJ-7777120
- JNJ-38518168
- Mianserin
- Thioperamide
- VUF-6002
|
|
|
Transporter
(inhibitors) |
VMATs |
TAAR1 inactive |
- Amiodarone
- APP
- AZIK
- Bietaserpine
- Deserpidine
- Dihydrotetrabenazine
- Efavirenz
- GBR-12935
- GZ-793A
- Ibogaine
- Ketanserin
- Lobeline
- Methoxytetrabenazine
- NBI-98854
- Reserpine
- Rose bengal
- SD-809
- Tetrabenazine
- Vanoxerine (GBR-12909)
|
|
TAAR1 active |
- Amphetamine
- Methamphetamine
- MDMA
- Phenethylamine
|
|
|
|
Enzyme
(inhibitors) |
HDC |
- Catechin
- Meciadanol
- Naringenin
- Tritoqualine
|
|
HNMT |
- Amodiaquine
- Diphenhydramine
- Harmaline
- Metoprine
- Quinacrine
- SKF-91,488
- Tacrine
|
|
DAO |
|
|
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Others |
|
|
Index of the respiratory system
|
|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Chest trauma
- Infection
- common cold
- pneumonia
- tuberculosis
- Other
- Symptoms and signs
|
|
Treatment |
- Procedures
- Drugs
- nasal
- throat
- obstructive airway diseases
- cough and cold
- histaminergics
- pulmonary arterial hypertension
- other
- Surgery
|
|
|
References
- ^ PDB: 3HI7 ; McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM (2009). "Structure and inhibition of human diamine oxidase". Biochemistry 36 (41): 9810–9822. doi:10.1021/bi9014192. PMC 2791411. PMID 19764817. ; rendered with PyMOL
- ^ Agúndez, JA; Ayuso, P; Cornejo-García, JA; Blanca, M; Torres, MJ; Doña, I; Salas, M; Blanca-López, N; Canto, G; Rondon, C; Campo, P; Laguna, JJ; Fernández, J; Martínez, C; García-Martín, E (2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLOS ONE 7 (11): e47571. doi:10.1371/journal.pone.0047571. PMID 23152756.
UpToDate Contents
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English Journal
- Mesenteric lymph duct drainage attenuates acute lung injury in rats with severe intraperitoneal infection.
- Zhang Y1, Zhang S, Tsui N.
- Inflammation.Inflammation.2015 Jun;38(3):1239-49. doi: 10.1007/s10753-014-0091-z.
- The purpose of this study is to investigate the hypothesis that the mesenteric lymphatic system plays an important role in acute lung injury in a rat model induced by severe intraperitoneal infection. Male Wistar rats weighing 250 ∼ 300 g were randomly divided into 3 groups and subjected to sh
- PMID 25537798
- Characterization of two amine oxidases from Aspergillus carbonarius AIU 205.
- Sugawara A1, Matsui D2, Yamada M1, Asano Y2, Isobe K3.
- Journal of bioscience and bioengineering.J Biosci Bioeng.2015 Jun;119(6):629-35. doi: 10.1016/j.jbiosc.2014.10.023. Epub 2014 Nov 22.
- We have reported that Aspergillus carbonarius AIU 205, which was isolated by our group, produced three enzymes exhibiting oxidase activity for 4-aminobutanamide (4-ABAD) (J. Biosci. Bioeng., 117, 263-268, 2014). Among three enzymes, characteristics of enzyme I have been revealed, but those of the ot
- PMID 25468423
- Inhibition and oxygen activation in copper amine oxidases.
- Shepard EM1, Dooley DM2.
- Accounts of chemical research.Acc Chem Res.2015 May 19;48(5):1218-26. doi: 10.1021/ar500460z. Epub 2015 Apr 21.
- Copper-containing amine oxidases (CuAOs) use both copper and 2,4,5-trihydroxyphenylalanine quinone (TPQ) to catalyze the oxidative deamination of primary amines. The CuAO active site is highly conserved and comprised of TPQ and a mononuclear type II copper center that exhibits five-coordinate, disto
- PMID 25897668
Japanese Journal
- The Role of Polyamines in Plant Disease Resistance
- 小児短腸症候群症例における血清 DAO 活性及び血漿シトルリン濃度の意義
- An Extended-gate Type Organic FET Based Biosensor for Detecting Biogenic Amines in Aqueous Solution
Related Links
- ジアミンオキシダーゼ(diamine oxidase)は、アルギニン、プロリン、ヒスチジン、 トリプトファン代謝酵素の一つで、次の化学反応を触媒する ... 組織名はhistamine: oxygen oxidoreductase (deaminating)で、別名にamine oxidase (ambiguous); amine oxidase ...
- Does anyone have any experience with, or thoughts on, taking diamine oxidase ( DAO) supplements to combat histamine intolerance? I believe 'Histame' is the brand available in the US and UK. I'm thinking of trying these to ...
★リンクテーブル★
[★]
- 関
- copper-containing amine oxidase、diamine oxidase、histaminase
[★]
- 英
- diamine oxidase
- 関
- 銅含有アミン酸化酵素、ジアミンオキシダーゼ、ヒスタミナーゼ
[★]
ヒスタミナーゼ
- 関
- copper amine oxidase、copper-containing amine oxidase、diamine oxidase
[★]
- 関
- copper amine oxidase、diamine oxidase、histaminase
[★]
- 英
- diamine oxidase
- 関
- ジアミン酸化酵素