vt.

(病気などを)さらに悪化させる、(負担、罪などを)一層重くする

if the problem is chronic and not corrected by removal of aggravating factors, placement of a permanent pacemaker is required.

関: aggravation、deteriorate、deterioration、exacerbate、exacerbation、exaggerate、exaggeration、worsen

WordNet

become worse or disintegrate; "His mind deteriorated"
action that makes a problem or a disease (or its symptoms) worse; "the aggravation of her condition resulted from lack of care" (同)exacerbation
unfriendly behavior that causes anger or resentment (同)irritation, provocation
an exasperated feeling of annoyance (同)exasperation
process of changing to an inferior state (同)decline in quality, declension, worsening
a symptom of reduced quality or strength (同)impairment
the act of making something more noticeable than usual; "the dance involved a deliberate exaggeration of his awkwardness"
making to seem more important than it really is (同)overstatement, magnification
a reckless attack with intent to injure seriously (as with a deadly weapon)
made more severe or intense especially in law; "aggravated assault"
incited, especially deliberately, to anger; "aggravated by passive resistance"; "the provoked animal attacked the child" (同)provoked
making worse (同)exacerbating, exasperating

PrepTutorEJDIC

…'を'もっとひどくさせる,悪化させる;〈罪など〉'を'重くする / 《話》〈人〉'を'いらいらさせる,怒らせる
…‘を'悪化させる;…‘の'品質などを低下させる / 〈人格・品質・価値などが〉悪化する,低下する
…‘を'『誇張する』,大げさに言う(考える) / 誇張する,大げさに言う
悪化,深刻化 / 〈C〉《話》腹立ちの原因
(価値・質などの)低下,悪化
〈U〉誇張,過大視 / 〈C〉誇張した表現,大げさな言い方
いらいらさせる,怒らせる,悪化させる

UpToDate Contents

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1. 低リン血症の徴候および症状signs and symptoms of hypophosphatemia [show details]
…with severe hypophosphatemia. Defective clot retraction and thrombocytopenia can occur, which can aggravate mucosal hemorrhage. The manifestations of hypophosphatemia depend upon the severity and chronicity…
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…hypokalemia by reducing sodium delivery to the distal nephron. Conversely, beta blockers are known to aggravate the perturbations of glucose metabolism associated with thiazides . Hydrochlorothiazide enhances …
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…therapy of delirium are based on the following principles: Avoiding factors known to cause or aggravate delirium, such as multiple medications, dehydration, immobilization, sensory impairment, and disruption …
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English Journal

Carbon black-induced detrimental effect on osteoblasts at low concentrations: Remarkably compromised differentiation without significant cytotoxicity.

Ren Q, Wu Y, Ma J, Shan Q, Liu S, Liu Y.
Ecotoxicology and environmental safety. 2019 Aug;178()211-220.
Due to similar aerodynamic and micro-nano sized properties between airborne particles and synthetic nanoparticles, a large number of studies have been conducted using carbon-based particles, such as carbon black (CB), carbon nanotubes and graphite, in order to achieve deeper understandings of their
PMID 31009927

LINC00520 targeting miR-27b-3p regulates OSMR expression level to promote acute kidney injury development through the PI3K/AKT signaling pathway.

Tian X, Ji Y, Liang Y, Zhang J, Guan L, Wang C.
Journal of cellular physiology. 2019 Aug;234(8)14221-14233.
Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, the current medical methods have limited therapeutic effects. The present study aimed to find out the molecular mechanism of AKI pathogenesis, which may provide new insights for future therapy. Bioinf
PMID 30684280

Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage.

Kanamaru H, Suzuki H.
Neural regeneration research. 2019 Jul;14(7)1138-1143.
Aneurysmal subarachnoid hemorrhage remains serious hemorrhagic stroke with high morbidities and mortalities. Aneurysm rupture causes arterial bleeding-induced mechanical brain tissue injuries and elevated intracranial pressure, followed by global cerebral ischemia. Post-subarachnoid hemorrhage ische
PMID 30804237

Japanese Journal

Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4

Infection and Immunity 85(9), e00277-17, 2017-09
NAID 120006334808

Environmental pollution and allergies

Journal of Toxicologic Pathology 30(3), 193-199, 2017-07-20
NAID 120006370729

骨盤内の複雑な血管病変に対する塞栓術

日本インターベンショナルラジオロジー学会雑誌 32(3), 218-226, 2017
NAID 130006243115

Cardiac Resynchronization Therapy in Patients with Ebstein's Anomaly

International Heart Journal 58(5), 816-819, 2017
NAID 130006179198

「exaggerate」

　　[★]

vt.

大げさに言う、誇張する。誇大に考える、過大視する。際だたせる
(病気、状態を)悪化させる、激化させる。(器官を)肥大させる

Pulsus paradoxus may also be manifest by other conditions in which inspiration is exaggerated, including severe asthma and chronic obstructive airway disease.

Exaggerated perifollicular neovascularization with some of the new blood vessels exhibiting increased permeability.(uptodate)()

vi.

誇張した言い方をする

関: (adj.)exaggerated 誇大な、過度の。(動)異常に大きな、肥大した

関: aggravate, aggravation, deteriorate, deterioration, exacerbate, exacerbation, exaggeration, worsen

「deteriorate」

　　[★]

(de-(悪化)+ -terior(より悪く) + -ate )より一層悪くする

vi.

悪くなる、(～に)悪化する(into)。(道徳などが)低下する、堕落する。衰える

As the disease progresses and speech deteriorates communication may be helped by using computers.(病気が悪化し、発話が悪くなったとき、コンピュータの使用で会話は補助されうる)

vt.

(価値・品質など)を悪くする、悪化させる。～を悪化させる

対: (vt.)ameliorate

関: aggravate, aggravation, alter, alteration, deterioration, exacerbate, exacerbation, exaggerate, exaggeration, worsen

「deterioration」

　　[★]

n.

悪化、低下

There is even concern that rapid recovery of the platelet pool during treatment may explain subsequent deterioration in some patients's clinical course.(WCH.1559)