WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
of or relating to or constituting a follicle
inflammation of the conjunctiva of the eye (同)pinkeye

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の

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1. アデノウイルス感染の疫学および臨床症状 epidemiology and clinical manifestations of adenovirus infection
2. 結膜炎 conjunctivitis
3. トラコーマの疫学、診断、およびマネージメント epidemiology diagnosis and management of trachoma
4. オウム病 psittacosis
5. 再発性多発性軟骨炎の病理 pathology of relapsing polychondritis

English Journal

[Bacterial conjunctivitis--diagnosis and therapy update].

Messmer EM.Author information Augenklinik der Ludwig-Maximilians-Universität, Klinikum der Universität München, Campus Innenstadt, München. emessmer@med.uni-muenchen.deAbstractAcute bacterial conjunctivitis is a common health-care issue for the general practitioner and the ophthalmologist. Signs and symptoms usually allow a correct diagnosis without conjunctival swab. Primary microbiological investigations are recommended in newborns, immunocompromised patients and cases of hyperacute conjunctivitis. Of concern are methicillin-resistant Staphylococcus aureus strains which have been isolated with increasing frequency in the last few years. Studies have demonstrated the faster clinical and microbiological cure of acute bacterial conjunctivitis with topical antibiotics. However, the development of resistance of the typical germs to all of the antibiotic groups is alarming and should influence therapeutic behaviour. Fluoroquinolones show good activity in the treatment of acute bacterial conjunctivitis but should be saved for severe infections due to its broad spectrum of activity. Antibiotics such as gentamycin, tobramycin, and azithromycin should be preferred. Considering the high spontaneous healing rate of acute conjunctivitis, delayed topical antibiotics in case of persistence after 3-4 days, or treatment without antibiotics using artificial tears and eye bathings may be considered. Additive anti-inflammatory drugs are generally not recommended. Chronic-recurrent follicular conjunctivitis necessitates testing for Chlamydia, and in case of a positive result, systemic antibiotic treatment of patient and sexual partner.
Klinische Monatsblätter für Augenheilkunde.Klin Monbl Augenheilkd.2012 May;229(5):529-33. doi: 10.1055/s-0031-1299523. Epub 2012 May 16.
Acute bacterial conjunctivitis is a common health-care issue for the general practitioner and the ophthalmologist. Signs and symptoms usually allow a correct diagnosis without conjunctival swab. Primary microbiological investigations are recommended in newborns, immunocompromised patients and cases
PMID 22592344

Acute primary canine herpesvirus-1 dendritic ulcerative keratitis in an adult dog.

Gervais KJ, Pirie CG, Ledbetter EC, Pizzirani S.Author information Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, USA. kgervais10@gmail.comAbstractWe present a report of dendritic ulcerative keratitis in a 4-year old locally immunosuppressed dog suspected to result from acute primary canine herpesvirus-1 (CHV-1) infection. The dog was presented for evaluation of mild blepharospasm and conjunctival hyperemia in the right eye (OD) shortly after attending a public boarding facility. For approximately 3 months, the dog had been receiving topical prednisolone acetate 1.0% and tacrolimus 0.02% in both eyes (OU) q12h for treatment of follicular conjunctivitis. Ophthalmic examination revealed three regions of corneal fluorescein retention OD. The lesions had a dendritic pattern, were approximately 2-3 mm in length, and were located at the dorsomedial, lateral, and ventromedial aspects of the cornea. No additional abnormalities were noted on complete ophthalmic and physical examinations. CHV-1 was identified in conjunctival samples OD by polymerase chain reaction, and paired CHV-1 serum virus neutralization antibody titers were positive and consistent with acute infection. Topical prednisolone acetate and tacrolimus were discontinued. The dog was treated with cidofovir 0.5% OU q12h for a period of 4 weeks, with resolution of corneal disease noted within 1 week of treatment. In conjunction with previous studies, this case report supports a central role for alterations in host immune status in the pathogenesis and clinical manifestations of CHV-1 ocular disease in dogs.
Veterinary ophthalmology.Vet Ophthalmol.2012 Mar;15(2):133-8. doi: 10.1111/j.1463-5224.2011.00952.x. Epub 2011 Sep 29.
We present a report of dendritic ulcerative keratitis in a 4-year old locally immunosuppressed dog suspected to result from acute primary canine herpesvirus-1 (CHV-1) infection. The dog was presented for evaluation of mild blepharospasm and conjunctival hyperemia in the right eye (OD) shortly after
PMID 22051326

A randomised placebo-controlled trial of topical steroid in presumed viral conjunctivitis.

Wilkins MR, Khan S, Bunce C, Khawaja A, Siriwardena D, Larkin DF.Author information Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK. mail@markwilkins.co.ukAbstractAIMS: To assess whether topical steroids improve patient comfort compared with hypromellose in acute presumed viral conjunctivitis.
The British journal of ophthalmology.Br J Ophthalmol.2011 Sep;95(9):1299-303. doi: 10.1136/bjo.2010.188623. Epub 2011 Jan 20.
AIMS: To assess whether topical steroids improve patient comfort compared with hypromellose in acute presumed viral conjunctivitis.METHODS: Patients presenting with acute follicular conjunctivitis, presumed viral in origin, were randomised to receive either dexamethasone 0.1% or hypromellose 0.3% dr
PMID 21252084