WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
a central nervous system stimulant that increases energy and decreases appetite; used to treat narcolepsy and some forms of depression (同)pep_pill, upper, speed
excitement and elation beyond the bounds of sobriety; "the intoxication of wealth and power"

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
アンフェタミン(中枢神経刺激済)
酔い,酩酊(めいてい) / 夢中,陶酔

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Acute 5-(2-Aminopropyl)Benzofuran (5-APB) Intoxication and Fatality: A Case Report with Postmortem Concentrations.

McIntyre IM1, Gary RD2, Trochta A2, Stolberg S2, Stabley R2.
Journal of analytical toxicology.J Anal Toxicol.2014 Nov 27. pii: bku131. [Epub ahead of print]
A 20-year-old man, a college student, became unresponsive in front of his girlfriend. He was known to consume alcohol and take an unknown drug at some point while in attendance at a local music festival earlier in the day/evening. Upon arrival of emergency personnel, he was noted to be asystolic and
PMID 25429871

Acute methoxetamine and amphetamine poisoning with fatal outcome: a case report.

Wiergowski M1, Anand JS, Krzyżanowski M, Jankowski Z.
International journal of occupational medicine and environmental health.Int J Occup Med Environ Health.2014 Aug;27(4):683-90. doi: 10.2478/s13382-014-0290-8. Epub 2014 Jul 24.
Methoxetamine (MXE) is a psychoactive substance distributed mostly via the Internet and is not liable to legal regulation in Poland. MXE has a toxicity profile similar to that of ketamine but longer-lasting effects. The paper describes a case of acute poisoning that resulted from recreational use of
PMID 25060403

Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use.

Kiyatkin EA1, Kim AH2, Wakabayashi KT2, Baumann MH2, Shaham Y2.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2014 Jun 4;34(23):7754-62. doi: 10.1523/JNEUROSCI.0506-14.2014.
MDMA (Ecstasy) is an illicit drug used by young adults at hot, crowed "rave" parties, yet the data on potential health hazards of its abuse remain controversial. Here, we examined the effect of MDMA on temperature homeostasis in male rats under standard laboratory conditions and under conditions tha
PMID 24899699